Human Immunology News Volume 7.28 | Jul 23 2019

TOP STORY

Fingerprint of Multiple Sclerosis Immune Cells Identified

Researchers identified a cell population that likely plays a key role in multiple sclerosis (MS). T helper cells in the blood of MS patients infiltrate the central nervous system, where they can cause inflammation and damage nerve cells. [Press release from the University of Zurich discussing online prepublication in Nature Medicine] Press Release | Abstract

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A Case Report of Clonal EBV-Like Memory CD4⁺ T Cell Activation in Fatal Checkpoint Inhibitor-Induced Encephalitis

Scientists report a fatal case of encephalitis arising during anti-programmed cell death receptor 1 therapy in a patient with metastatic melanoma. Histologic analyses revealed robust T cell infiltration and prominent programmed death ligand 1 expression. [Nat Med] Abstract | Press Release

Predicting Bacterial Infection Outcomes Using Single Cell RNA-Sequencing Analysis of Human Immune Cells

Using single cell RNA-sequencing of human peripheral blood cells infected with Salmonella, the authors developed a deconvolution algorithm for inferring cell-type specific infection responses from bulk measurements. [Nat Commun] Full Article | Press Release

Super-Resolution Microscopy Reveals Ultra-Low CD19 Expression on Myeloma Cells that Triggers Elimination by CD19 CAR-T

Investigators applied single molecule-sensitive direct stochastic optical reconstruction microscopy, and demonstrated CD19 expression on a fraction of myeloma cells in 10 out of 14 patients. [Nat Commun] Full Article

Comprehensive Immune Monitoring of Clinical Trials to Advance Human Immunotherapy

To broadly enumerate immune cell identity and activity, scientists established and extensively assessed a reference panel of 33 antibodies to cover major cell subsets, simultaneously quantifying activation and immune checkpoint molecules in a single assay. [Cell Rep] Full Article | Graphical Abstract

Hepatoma-Derived Growth Factor Participates in Helicobacter pylori-Induced Neutrophils Recruitment, Gastritis and Gastric Carcinogenesis

Researchers elucidated the role of hepatoma-derived growth factor (HDGF) in H. pylori-induced gastric inflammation and carcinogenesis. HDGF expression in gastric biopsy and serum from patients was analyzed by immunohistochemical and ELISA analysis, respectively. [Oncogene] Abstract

Upregulation of SLAMF3 on Human T Cells Is Induced by Palmitic Acid through the STAT5-PI3K/Akt Pathway and Features the Chronic Inflammatory Profiles of Type 2 Diabetes

Scientists found a significant upregulation of signaling lymphocytic activation molecule family member 3 (SLAMF3) expression on T cells from type 2 diabetes patients compared to those of healthy controls. [Cell Death Dis] Full Article

An Oligo-His-Tag of a Targeting Module Does Not Influence Its Biodistribution and the Retargeting Capabilities of UniCAR T Cells

The authors constructed target modules (TMs) against prostate stem cell antigen equipped with or lacking an oligo-His-tag. Both TMs were compared side by side for functionality and biodistribution. [Sci Rep] Full Article

Silencing RORγt in Human CD4⁺ T Cells with CD30 Aptamer-RORγt shRNA Chimera

Investigators report that an RNA CD30 aptamer was utilized to deliver short hairpin RNA (shRNA) to CD30⁺ T cells to target retinoic acid receptor-related orphan receptor gamma t (RORγt), leading to impaired expression of RORγt and suppression of IL-17A and IL-17F. [Sci Rep] Full Article

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Therapeutic and Diagnostic Implications of T Cell Scarring in Celiac Disease and Beyond

Disease-specific CD4⁺ T cells form an immunological scar in celiac disease and probably other autoimmune disorders. The authors discuss how such T cells may be targeted for better treatment and diagnosis via their antigen specificity or via their expression of characteristic phenotypic markers. [Trends Mol Med] Full Article

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Avalon GloboCare and GE Healthcare Announce Strategic Partnership to Accelerate Standardized Automation and Bio-Production for Cellular Medicines

Avalon GloboCare Corp. announced that they have established a strategic partnership with GE Healthcare. The partnership will accelerate Avalon’s standardization, automation and bio-production for clinical-grade CAR-T cells and other immune-effector cells for cellular immunotherapy, as well as exosomes/extracellular vesicles based regenerative therapeutics. [Avalon GloboCare Corp.] Press Release

Adaptimmune Starts the SURPASS Clinical Trial with Its First Next-Generation SPEAR T-Cells Targeting MAGE‑A4 to Enhance Antitumor Responses

Adaptimmune Therapeutics plc has initiated SURPASS, its first clinical trial with a next-generation SPEAR T-cell targeting MAGE-A4. [Adaptimmune Therapeutics plc] Press Release

Budget Deal Raises Hopes for US Research Agencies

A new budget deal between the White House and congressional leaders means US research agencies could receive increases on the order of the 4% to 5% that Democrats have already proposed for next year. [ScienceInsider] Editorial

What Boris Johnson’s Leadership Could Mean for Science

Boris Johnson has been selected as the United Kingdom’s new prime minister — and is poised to lead the country out of the European Union. At the forefront of many scientists’ minds are questions about how Johnson’s leadership, including his support for a ‘no deal’ Brexit, will affect research. They fear that British science has much to lose from a messy departure from the EU. [Nature News] Editorial

NEW 2019 National Cancer Research Institute (NCRI) Cancer Conference
November 3-5, 2019
Glasgow, United Kingdom

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NEW Scientific Communications Coordinator (STEMCELL Technologies Inc.)

NEW Preclinical Scientist – Immunology (MiroBio)

Research Associate – Human Immunology (STEMCELL Technologies Inc.)

Scientist – Human Immunology (STEMCELL Technologies Inc.)

Research Associate – Immune Cell Culture (STEMCELL Technologies Inc.)

PhD Position – Extracellular Matrix & Skin Immunology (University of Freiburg)

Postdoctoral Position – Mucosal Immunology (University of California San Diego)

Postdoctoral Research Scientist – Molecular Immunology (Babraham Institute)

PhD Fellowship – Immunology (University of Oslo)

Senior Scientist – Immuno-Oncology of Hematologic Malignancies (University of Kansas School of Medicine)

Postdoctoral Fellow – Tumor Immunology (Massachusetts General Hospital and Harvard Medical School)

Senior Research Assistant – Immunology (MD Anderson Cancer Center)

Postdoctoral Fellow – Immunology (Boston University)

Postdoctoral Position – Immunology of Enteric Infections (University of Utah)

Assistant/Associate or Professor – Cancer Immunotherapy/Tumor Immunology (University of California, Irvine)

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