Human Immunology News 7.40 October 15, 2019 | |
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TOP STORYCXCR5+CD8+T cells were partially exhausted but possessed a stronger antiviral ability than the CXCR5− subset in patients with chronic hepatitis B virus (HBV) infection; moreover, CXCR5+CD8+T cells were associated with a favorable treatment response in chronic hepatitis B patients. [J Hepatol] Full Article | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Recognition of Human Gastrointestinal Cancer Neoantigens by Circulating PD-1+ Lymphocytes Researchers used a personalized high-throughput screening strategy to investigate whether PD-1 expression in peripheral blood could be used to identify CD8+ or CD4+ lymphocytes recognizing neoantigens identified by whole-exome sequencing in seven patients with gastrointestinal cancer. [J Clin Invest] Full Article | Graphical Abstract Maturation of the Human Intestinal Immune System Occurs Early in Fetal Development Using mass cytometry and next-generation sequencing of B and T cell receptor repertoires, scientists demonstrated complex intestinal immunity from 16 weeks’ gestational age. [Dev Cell] Abstract | Graphical Abstract CD14+SIRPαhi cells expressed common monocyte/macrophage markers; exhibited characteristic differentiation, migration, and phagocytosis; and suppressed T-cell function. [Blood Cancer J] Full Article Researchers found that PD-L1 was not highly expressed in the tumor microenvironment of human ovarian cancer. Instead, B7-H3, another checkpoint molecule, was highly expressed by both tumor cells and tumor-infiltrating antigen-presenting cells, which correlated with T-cell exhaustion in patients. [Cell Mol Immunol] Abstract Results showed that CCL2 expression was associated with the treatment status of multiple myeloma (MM) patients. Macrophages interacted with MM cells and further upregulate their expression of CCL2. [Cell Death Dis] Full Article The authors investigated the expression and function of tumor-associated macrophage (TAM) subsets in oral squamous cell carcinoma (OSCC), especially in cancer cell proliferation. Biopsy sample from 44 patients with OSCC were examined for the expression of TAM markers and EGF by immunohistochemistry. [Sci Rep] Full Article Scientists investigated frequencies of monocytes subsets in blood and their response to hydroxyurea therapy, testing their ability to express pro-inflammatory molecules and tissue factor. [Sci Rep] Full Article Investigators report a protein-coding gene CLEC5A, which is the top 1 gene by univariate Cox regression analysis of 524 primary GBM samples. Expression of CLEC5A was significantly correlated with decreased overall survival in patients with glioma via large-scale analysis. [Cancer Gene Ther] Abstract Subscribe to our sister publications: Immunology of Infectious Disease News & Immune Regulation News. | |
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REVIEWSThe authors discuss recent insights into the generation, homing, retention, and survival of resident memory T (TRM) cells and share their perspectives on the biological characteristics of TRM cells in the recurrence of inflammatory skin disorders. [Cell Mol Immunol] Abstract Visit our reviews page to see a complete list of reviews in the human immunology research field. | |
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INDUSTRY NEWSCity of Hope Helps Found Biotechnology Hub for Los Angeles County’s Life Sciences Industry City of Hope announced that it is a founding sponsor of Bioscience Los Angeles County, a nonprofit aiming to catalyze biotechnology and life sciences innovation in the region. [City of Hope] Press Release BostonGene Announces Cancer Research Collaboration with Washington University in St. Louis BostonGene Corporation announced a master agreement with Washington University School of Medicine in St. Louis to collaborate on multiple research projects. [BostonGene Corporation] Press Release | |
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POLICY NEWSHundreds of Scientists Declare Support for Extinction Rebellion Almost 1,000 scientists have signed a declaration supporting civil disobedience protests that urge government action on climate change. [The Scientist] Editorial Canadian Election Leaves Scientists Hanging — No Matter Who Wins Canada’s two main political parties are running neck and neck in the lead-up to the country’s general election on 21 October. It’s unclear which party will come out on top, and that uncertainty extends to how science will fare in the next government. [Nature News] Editorial Thousands of Grant Peer Reviewers Share Concerns in Global Survey Researchers spend around ten days every year reviewing other academics’ funding proposals, according to the largest ever survey of grant peer review. The Grant Review In Focus report — based on a survey of 4,700 researchers worldwide — also found that recognition is an important incentive for reviewers. [Nature News] Editorial
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EVENTSNEW 40th European Workshop for Rheumatology Research (EWRR) Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Research Officer – CAR T-Cell Immunotherapy (Centenary Institute) Research Technologist (STEMCELL Technologies Inc.) Scientist – Human Immunology (STEMCELL Technologies Inc.) Postdoctoral Position – Blood Cancer Immunology (University Children’s Hospital Basel) Senior Scientist – Immunology (Regensburg Center for Interventional Immunology) Senior Scientific Researcher – Immunology Discovery (Genentech, Inc.) Senior Associate Scientist – Molecular and Cellular Neuroimmunology (Amgen) Research Technician – Immune Cells (Flanders Institute for Biotechnology) Postdoctoral Position – Stem Cell Biology and Immunology (Columbia University) Postdoctoral Research Associate – Autoimmune Diseases (Benaroya Research Institute) Senior Scientific Researcher – Inflammatory Diseases (Genentech, Inc.) Postdoctoral Position – Immunology of Enteric Infections (University of Utah) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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