| Vol. 8.26 – 07 July, 2020 |
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| Scientists investigated the dynamics of mRNA translation kinetics and protein turnover in human naive and activated T cells. [Nature Immunology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers identified circulating CD88−CD1c+CD163+ denritic cells (DCs) as immediate precursors of inflammatory CD88−CD14+CD1c+CD163+FcεRI+ DCs. [Immunity] |
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| The authors showed that adipose tissue eosinophils undergo major age-related changes in distribution and function associated with impaired adipose tissue homeostasis and systemic low-grade inflammation in both humans and mice. [Nature Metabolism] |
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| The authors report an efficient CRISPR/Cas9-based approach that targeted glucocerebrosidase expression cassettes with a monocyte/macrophage-specific element to the CCR5 safe-harbor locus in human hematopoietic stem and progenitor cells. [Nature Communications] |
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| Researchers suggested a previously unidentified method for xenogenizing tumors by using fusogenic exosomes to introduce fusogenic viral antigens onto the tumor cell surface. [Science Advances] |
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| Of clinical importance, CD26high and TH17 cells engineered with a chimeric antigen receptor regressed large human tumors to a greater extent than enriched TH1 or TH2 cells. [Science Advances] |
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| Allografts were rapidly infiltrated by recipient leukocytes, which recapitulated the liver myeloid and lymphoid composition, and underwent partial reprogramming with acquisition of CD68/CD206 on MNPs and CD69/CD103 on T cells. [Journal of Experimental Medicine] |
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| Scientists developed a novel CD8+ CAR T-cell product, Descartes-08, with predictable pharmacokinetics for treatment of multiple myeloma. Descartes-08 was engineered by mRNA transfection to express anti-BCMA CAR for a defined length of time. [Leukemia] |
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| Researchers identified erythroid membrane-associated protein (ERMAP) as a novel T cell inhibitory molecule. ERMAP shared significant sequence and structural homology with existing B7 family members in its extracellular domain. [Cellular & Molecular Immunology] |
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| The tumor and TIL phenotypic characteristics of 134 HNSCC specimens were retrospectively analysed. HNSCC data from the Cancer Genome Atlas were analysed for CD8α, HPV and overall survival. [British Journal of Cancer] |
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| The authors report that the expression of CXCL5 was elevated in tumor tissues and positively associated with lymphatic metastasis and tumor differentiation. [Oncogenesis] |
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| Scientists utilized immunodeficient NOD-scid IL2rγnull (NSG) mice that carried in vivo-generated engineered human skin (ES). ES was generated from human keratinocytes and fibroblasts and was initially devoid of skin-resident immune cells. [Scientific Reports] |
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| Through the successes of checkpoint blockade and adoptive cellular therapy, immunotherapy has become an established treatment modality for cancer. [Nature Reviews Cancer] |
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| The T cell receptors–peptide-MHC interaction mediates’ between a T cell and its target cell dictates its function and thereby influences its role in disease. [Nature Metabolism] |
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| Investigators cover the contribution of FcγRs to antigen-presentation with a focus on the intracellular trafficking of IgG-immune complexes and the pathways that support this function. [Frontiers in Immunology] |
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| Cabaletta Bio, Inc. announced they have signed a research and collaboration agreement to accelerate development of next-generation CAAR T cell therapies for patients with B cell-mediated autoimmune diseases. [Calbetta Bio, Inc.] |
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| In mid-March, as businesses and universities across Europe were shutting down in a bid to slow the COVID-19 pandemic, three longtime friends were talking about how they wished they could do something to combat the disease. [The Scientist] |
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| August 17 – August 19 Virtual |
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| Lerner Research Institute – Cleveland, Ohio, United States |
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| University of California Los Angeles – Los Angeles, California, United States |
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| Ohio State University – Columbus, Ohio, United States |
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| H. Lee Moffitt Cancer Center & Research Institute – Tampa, Florida, United States |
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| Terasaki Institute for Biomedical Innovation – Los Angeles, California, United States |
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