 | | Vol. 8.27 – 14 July, 2020 |
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| Using genome editing methods, scientists disrupted uridine monophosphate synthetase (UMPS) in the pyrimidine de novo synthesis pathway in cell lines, pluripotent cells and primary human T cells.
[Nature Biotechnology] |
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 | | Researchers found that S-specific antibodies, memory B cells and circulating follicular helper T cell were consistently elicited after SARS-CoV-2 infection, demarking robust humoral immunity and positively associated with plasma neutralizing activity.
[Nature Medicine] |
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| Investigators conducted a Phase Ib, placebo-controlled, randomised clinical trial of two dose levels of naproxen sodium administered daily for six months to 80 participants with Lynch syndrome (LS), and a co-clinical trial using a genetically engineered mouse model of LS and patient-derived organoids
[Gut] |
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| Researchers demonstrated that the induction of a regulatory program in human B cells was dependent on a metabolic priming event driven by cholesterol metabolism.
[Nature Communications] |
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| Scientists showed that the Parkinson’s disease‐related kinase LRRK 2 was activated in macrophages by pathogen‐ or sterile‐induced endomembrane damage.
[EMBO Journal] |
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| Using ex vivo and in vivo models of metastasis, researchers established that keratin-14+ breast cancer cells were vulnerable to natural killer cells.
[Journal of Cell Biology] |
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| Investigators modified the key variables of cell number and the peptide pulsing method to improve ex vivo detection of HBV-specific T cells.
[Scientific Reports] |
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| Freshly resected prostate specimens were processed to obtain single-cell suspensions, and immune-phenotyped for major lymphoid and myeloid cell subsets by staining with two separate 14-antibody panels and multicolor flow cytometry analysis.
[Prostate Cancer and Prostatic Diseases] |
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| Ovarian clear cell carcinoma cell lines carrying wild-type p53 with low/high mouse double minute 2 homolog (MDM2) expression were investigated in a T-cell co-culture system evaluating T-cell-mediated tumor killing.
[Cell Death Discovery] |
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| Scientists showed that after prolonged in vitro stimulation, a significant proportion of human regulatory T cells gained stable CD70 expression while losing CD27.
[Communications Biology] |
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| The authors focus on existing and potential immune targets for PDAC, drugs used to target them, and some clinical trials conducted so far with them.
[Molecular Biology Reports] |
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| US President Donald Trump’s government has dropped its plans to deport international students whose courses move fully online because of the coronavirus pandemic.
[BBC] |
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| To address the problem of poor reporting, Percie du Sert and a team of researchers have developed a checklist of 10 critical details each animal study needs to report, such as the number of animals used, their sex, whether they were randomly allocated to a test group and control group, and whether the researchers knew which animal was in which group.
[Science Insider] |
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| SOTIO announced that the first patient has been dosed in Part B of the ongoing Phase I/Ib study of IL-15 superagonist, SO-C101, for the treatment of patients with advanced/metastatic solid tumors. Part B will examine SO-C101 in combination with PD-1 inhibitor pembrolizumab. The trial is conducted in partnership with Cytune Pharma.
[Sotio] |
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| | The University of Texas Southwestern Medical Center – Dallas, Texas, United States |
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| | Lerner Research Institute – Cleveland, Ohio, United States |
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| | University of California Los Angeles – Los Angeles, California, United States |
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| | Ohio State University – Columbus, Ohio, United States |
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| | H. Lee Moffitt Cancer Center & Research Institute – Tampa, Florida, United States |
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Cancer Stem Cell News
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