 | | Vol. 8.28 – 21 July, 2020 |
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| Scientists developed a highly multiplexed screen to quantify the co-expression of 351 surface molecules on millions of human B cells.
[Immunity] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators revealed malignant signatures capturing intratumoral transcriptional heterogeneity and predicting aggressiveness of malignant cells. Diverse immune cell subtypes were identified, including novel subtypes such as CLEC9A+ dendritic cells
[Cell Research] |
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| Longitudinal immune-monitoring reveals remodeling of the T-cell receptor repertoire with immunodominant clones and serum autoantibodies reactive to oncogenic signaling pathway proteins.
[Nature Communications] |
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| Serum cytokine and catecholamine levels were measured prior to lymphodepleting chemotherapy, on the day of CAR T infusion and daily thereafter while patients remained hospitalized.
[Clinical Cancer Research] |
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| To investigate how neonatal γδ T cell repertoires were shaped by microbial exposure after birth, the authors monitored the γ-chain and δ-chain repertoires of peripheral blood T cells in newborns, infants, and young children from Europe and sub-Saharan Africa.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Treatment‐naïve patients with metastatic colorectal cancer were assessed for CD8+ tumor-infiltrating lymphocutes and PD‐L1 expression. Microsatellite instability was evaluated by IHC for PMS2 and MSH6 proteins and/or by PCR using the Bethesda panel.
[Clinical & Translational Immunology] |
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| Overall survival by immune and immune-checkpoint biomarkers in independent colorectal cancer cohorts was evaluated. Matched mutational and transcriptomic data were interrogated to identify associated biology.
[British Journal of Cancer] |
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| 107 patients diagnosed with pancreatic ductal adenocarcinoma were retrospectively examined. The relationship between p53 mutations as well as PD-L1 abnormal expression and clinicopathological factors was investigated using immunohistochemistry.
[British Journal of Cancer] |
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| An efficient approach was described to genetically edit human NK cells by electroporation and CRISPR‐Cas9 ribonucleoprotein complexes.
[Journal of Leukocyte Biology] |
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| The effect of intravenous fluids exposure on single cells was characterized using hemocytometer, fluorescence microscopy and flow cytometry
[Scientific Reports] |
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| Ovarian clear cell carcinoma cell lines carrying wild-type p53 with low/high mouse double minute 2 homolog (MDM2) expression were investigated in a T-cell co-culture system evaluating T-cell-mediated tumor killing.
[Cell Death Discovery] |
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| Scientists introduce the NK cell–cancer cycle to highlight recent advances in NK cell biology and to discuss the progress and problems of NK cell-based cancer immunotherapies.
[Nature Immunology] |
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| The authors focus on existing and potential immune targets for PDAC, drugs used to target them, and some clinical trials conducted so far with them.
[Molecular Biology Reports] |
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| AC Immune SA announced the initiation of the second highest dosing group in the company’s Phase Ib/IIa clinical trial evaluating ACI-35.030 for the treatment of Alzheimer’s disease.
[AC Immune] |
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| GlyTherix Ltd has announced that a consortium led by the company are the successful recipients of a competitive grant in Round 9 of the Federal Government’s Cooperative Research Centers Projects program.
[GlyTherix Ltd.] |
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| Following a marathon EU summit in Brussels, national leaders agreed to a €1.8 trillion, seven-year budget and pandemic recovery fund that will spend €81 billion on Horizon Europe, the main EU research program.
[ScienceInsider] |
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| Early data on the effects of the coronavirus pandemic on scientific-publishing output suggest that female researchers, particularly those at early-career stages, are the hardest hit. Submissions to preprint servers, such as arXiv, rose more quickly for male authors than for female authors as nations adopted social-isolation measures.
[Nature News] |
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| Come August, hundreds of universities across the United States are poised to reopen their campuses with a mix of online and in-person courses. Only a handful are aiming for an entirely online semester. But as the machinery of higher education cranks back into action, faculty, staff, and students are voicing concerns that, with COVID-19 cases surging in many parts of the country, employees are being forced to put their health—and the health of others—at unnecessary risk.
[ScienceInsider] |
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| October 20 – October 21
Virtual |
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| | University of Dundee – Dundee, United Kingdom |
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| | The University of Texas Southwestern Medical Center – Dallas, Texas, United States |
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| | Lerner Research Institute – Cleveland, Ohio, United States |
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| | University of California Los Angeles – Los Angeles, California, United States |
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| | Ohio State University – Columbus, Ohio, United States |
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