Human Immunology News Volume 8.31 | August 11 2020

May 12, 2022

HIN 8.31 | Aug 11

Human Immunology News by STEMCELL Technologies

Vol. 8.31 – 11 August, 2020

TOP STORY

A Peripheral Immune Signature of Responsiveness to PD-1 Blockade in Patients with Classical Hodgkin Lymphoma

Investigators utilized the complementary approaches of T cell receptor sequencing and cytometry by time-of-flight analysis to obtain a peripheral immune signature of responsiveness to PD-1 blockade in 56 patients treated in the CheckMate 205 Phase II clinical trial
[Nature Medicine]

Abstract

Use ImmunoCult™ to differentiate mouse CD4+ cells to Tregs.

PUBLICATIONSRanked by the impact factor of the journal

Comprehensive Analyses of B Cell Compartments across the Human Body Reveal Novel Subsets and a Gut Resident Memory Phenotype

Data sets revealed that B cells in the blood were not in homeostasis with compartments in other tissues. Investigators found striking donor-to-donor variability in the frequencies and isotype of CD27⁺ memory B cells
[Blood]

Abstract

Prostaglandin E2 Stimulates cAMP Signaling and Re-Sensitizes Human Leukemia Cells to Glucocorticoid-Induced Cell Death

To identify glucocorticoid resistance pathways, investigators conducted a genome-wide, survival-based, shRNA screen in murine T cell acute lymphoblastic leukemia cells.
[Blood]

Abstract

Reversal of Pre-Existing NGFR-Driven Tumor and Immune Therapy Resistance

Researchers chronically exposed patient-derived melanoma cell lines to differentiation antigen-specific cytotoxic T cells and observed strong enrichment of a pre-existing NGFR^hi population.
[Nature Communications]

Full Article

Blockade of the AHR Restricts a Treg-Macrophage Suppressive Axis Induced by L-Kynurenine

The authors showed that the aryl hydrocarbon receptor (AHR) pathway was selectively active in indoleamine 2,3-dioxygenase 1 and tryptophan 2,3-dioxygenase 2-overexpressing tumors and was associated with resistance to immune checkpoint inhibitors.
[Nature Communications]

Full Article

Chromatin Accessibility Landscape of Pediatric T-Lymphoblastic Leukemia and Human T-Cell Precursors

Developmental stages were distinguished by 2,823 signature chromatin regions with 95% accuracy. Open chromatin surrounding SAE 1 was identified to best distinguish thymic developmental stages suggesting a potential role of SUMOylation in T‐cell development.
[EMBO Molecular Medicine]

Full Article

Infection during the First Year in Patients Treated with CD19 CAR T Cells for Diffuse Large B Cell Lymphoma

The authors analyzed 60 patients with diffuse large B cell lymphoma treated with FDA-approved CD19 chimeric antigen receptor (CAR) T cells and report the incidence, risk factors, and management of infections during the first year after treatment.
[Blood Cancer Journal]

Full Article

Mitochondrial DNA Enhance Innate Immune Responses in Neuromyelitis Optica by Monocyte Recruitment and Activation

Investigators established anti-AQP4 recombinant autoantibodies from plasmablasts in neuromyelitis optica spectrum disorder patient’s cereberospinal fluid.
[Scientific Reports]

Full Article

Myeloid-Derived Suppressor Cell Depletion Therapy Targets IL-17A-Expressing Mammary Carcinomas

The authors report here that IL-17A mRNA and protein were detectable in some human triple-negative breast cancer cell lines and further upregulated by IL-23 and LPS stimulation.
[Scientific Reports]

Full Article

EPHA5 Mutation Predicts the Durable Clinical Benefit of Immune Checkpoint Inhibitors in Patients with Lung Adenocarcinoma

Scientists report that Eph receptor A5 (EPHA5) mutations were associated with increased tumor mutation burden, neoantigen load, levels of immune-related gene expression signatures, and enhanced tumor-infiltrating lymphocytes in lung adenocarcinoma.
[Cancer Gene Therapy]

Abstract

LW-213 Induces Cell Apoptosis in Human Cutaneous T-cell Lymphomas by Activating PERK–eIF2α–ATF4–CHOP Axis

Researchers showed that LW-213 dose-dependently inhibited human cutaneous T-cell lymphoma cell lines with IC50 values of around 10 μM, meanwhile it potently inhibited primary leukemia cells derived from peripheral blood of T-cell lymphoma patients.
[Acta Pharmacologica Sinica]

Abstract

Tools and products for your COVID-19 research.

REVIEWS

Antitumor Dendritic Cell Vaccination in a Priming and Boosting Approach

The authors believe that currently available strategies for vaccines that target dendritic cells or use them to present antitumor antigens could be integrated into existing clinical practice using prime-boost approaches.
[Nature Reviews Drug Discovery]

Abstract

Targeting Tumor‐Associated Antigens in Hepatocellular Carcinoma for Immunotherapy: Past Pitfalls and Future Strategies

Investigators propose a new vaccine platform that enhances all three arms of the adaptive immune system to improve tumor‐associated antigens‐based cancer vaccination in hepatocellular carcinoma patients.
[Hepatology]

Abstract

INDUSTRY AND POLICY NEWS

Celyad to Begin Phase I Trial of Donor-Derived CAR T-Cell Therapy for Multiple Myeloma

Celyad Oncology SA announced that the company’s Investigational New Drug (IND) application for CYAD-211, the company’s first-in-class short hairpin RNA-based allogeneic CAR T candidate and second non-gene edited off-the-shelf program, is in effect with the FDA.
[Celyad Oncology SA]

Press Release

Hemogenyx Partners with UPenn to Study CAR T-Cell Therapy in AML

Hemogenyx Pharmaceuticals has inked a research agreement with the University of Pennsylvania (UPenn) for its CAR T-cell therapy for acute myeloid leukemia (AML).
[Hemogenyx Pharmaceuticals (Precision Oncology News)]

Press Release

FEATURED EVENT

A Peripheral Immune Signature of Responsiveness to PD-1 Blockade in Patients with Classical Hodgkin Lymphoma

Comprehensive Analyses of B Cell Compartments across the Human Body Reveal Novel Subsets and a Gut Resident Memory Phenotype

Prostaglandin E2 Stimulates cAMP Signaling and Re-Sensitizes Human Leukemia Cells to Glucocorticoid-Induced Cell Death

Reversal of Pre-Existing NGFR-Driven Tumor and Immune Therapy Resistance

Blockade of the AHR Restricts a Treg-Macrophage Suppressive Axis Induced by L-Kynurenine

Chromatin Accessibility Landscape of Pediatric T-Lymphoblastic Leukemia and Human T-Cell Precursors

Infection during the First Year in Patients Treated with CD19 CAR T Cells for Diffuse Large B Cell Lymphoma

Mitochondrial DNA Enhance Innate Immune Responses in Neuromyelitis Optica by Monocyte Recruitment and Activation

Myeloid-Derived Suppressor Cell Depletion Therapy Targets IL-17A-Expressing Mammary Carcinomas

EPHA5 Mutation Predicts the Durable Clinical Benefit of Immune Checkpoint Inhibitors in Patients with Lung Adenocarcinoma

LW-213 Induces Cell Apoptosis in Human Cutaneous T-cell Lymphomas by Activating PERK–eIF2α–ATF4–CHOP Axis

Antitumor Dendritic Cell Vaccination in a Priming and Boosting Approach

Targeting Tumor‐Associated Antigens in Hepatocellular Carcinoma for Immunotherapy: Past Pitfalls and Future Strategies

Celyad to Begin Phase I Trial of Donor-Derived CAR T-Cell Therapy for Multiple Myeloma

Hemogenyx Partners with UPenn to Study CAR T-Cell Therapy in AML

Virtual Meeting: Translational Immunology

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Postdoctoral Fellow – Immunotherapy

Postdoctoral Fellow – Autoimmune Pathogenesis

Postdoctoral Fellow – Role and Regulation of Inflammatory Cells

Postdoctoral Researcher – Intestinal Immune Responses to Infection

Postdoctoral Positions – Inflammatory Bowel Diseases and Tumor Immunology

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