 | | Vol. 8.32 – 18 August, 2020 |
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| Investigators simultaneously assayed single-cell heteroplasmy and cell state in thousands of blood cells obtained from three unrelated patients who had A3243G-associated mitochondrial encephalomyopathy, lactic acidosis, and strokelike episodes.
[New England Journal of Medicine] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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 | | The authors provide evidence that itaconate modified NLRP3 and inhibited inflammasome activation. Itaconate and its derivative, 4-octyl itaconate, inhibited NLRP3 inflammasome activation, but not AIM2 or NLRC4.
[Cell Metabolism] |
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| Investigators designed an αHER2 antibody–sialidase conjugate that potently and selectively stripped diverse sialoglycans from breast cancer cells.
[Nature Chemical Biology] |
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| Scientists compared the peripheral blood mononuclear cells (PBMC) mitochondrial respiration of 19 hospitalized Stage D heart failure patients with 19 healthy participants. They then created an in vitro model of sterile inflammation by treating healthy PBMC with MitoDAMP isolated from human heart tissue.
[Journal of Clinical Investigation] |
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| Researchers characterized the ontogeny of skeletal muscle-resident macrophages by lineage tracing and bone marrow transplant experiments.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Investigators created a stable cystic fibrosis transmembrane conductance regulator (CFTR) knockout in human macrophages in order to study how CFTR regulates macrophage function.
[Frontiers in Immunology] |
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| Using a microfluidic-based platform, researchers investigated the migration characteristics and performance of anticancer response of cytotoxic T lymphocyte targeting hepatic cancer cells via antigen-specific and allogeneic recognition.
[Scientific Reports] |
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| Human THP-1 monocytes were activated with phorbol-12-myristate-13-acetate and differentiated into M1 macrophages with IFNγ or M2 macrophages with IL4.
[Scientific Reports] |
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| A total of 36 tissue samples from tumors, peritumoral tissue, and adjacent healthy esophageal tissue was obtained from 12 esophageal carcinoma patients, and the surface expression of CD47 was evaluated in NK cells, CD8+ T cells, and the nonlymphocyte cell fraction.
[Scientific Reports] |
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| By integrating clinical characteristics, exome and RNA sequencing, and inhibitor data from primary acute myeloid leukemia (AML) samples from patients, investigators determined that myelomonocytic leukemia and upregulation of BCL2A1 and CLEC7A, as well as mutations of PTPN11 and KRAS, conferred resistance to venetoclax and multiple venetoclax combinations.
[Nature Cancer] |
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| Scientists compared four state-of-the-art methods and propose an approach to assign derived latent factors to pathway activities and specific cell subsets.
[iScience] |
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| The authors evaluate the potential benefits to the immune system that arise by taking advantage of some of the brain’s unique features, such as its capacity to integrate and synchronize physiological functions, its predictive capacity and its speed of response.
[Nature Reviews Immunology] |
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| Ultimovacs ASA announced that patient enrolment has been completed in the ongoing US-based Phase I clinical trial testing Ultimovacs’ lead candidate, UV1, in combination with pembrolizumab as first line treatment in patients with metastatic malignant melanoma.
[Ultimovacs ASA] |
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| Precigen, Inc. announced that the first patient has been dosed with Precigen’s PRGN-2009, a first-in-class, off-the-shelf investigational immunotherapy utilizing the AdenoVerseâ„¢ platform designed to activate the immune system to recognize and target HPV+ solid tumors.
[Precigen, Inc.] |
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| | Princess Margaret Cancer Center – Toronto, Ontario, Canada |
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| | Roswell Park Center for Immunotherapy – Buffalo, New York, United States |
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| | Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States |
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| | The Francis Crick Institute – London, United Kingdom |
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| | The University of Texas Southwestern Medical Center – Dallas, Texas, United States |
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