Human Immunology News Volume 8.36 | Sep 15 2020

May 12, 2022

2020-15-09 | HIN 8.36

Human Immunology News by STEMCELL Technologies

Vol. 8.36 – 15 September, 2020

TOP STORY

Absent B Cells, Agammaglobulinemia, and Hypertrophic Cardiomyopathy in Folliculin Interacting Protein 1 Deficiency

The authors investigated three novel patients, including the first known adult, from unrelated families with agammaglobulinemia, recurrent infections, and hypertrophic cardiomyopathy.
[Blood]

Abstract

Virtual Conference Exhibition: Immunology

PUBLICATIONSRanked by the impact factor of the journal

Retinoic Acid-Responsive CD8 Effector T-Cells Are Selectively Increased in IL-23-Rich Tissue in Gastrointestinal GvHD

Investigators used conventional and novel sequential immunostaining and flow cytometry to scrutinize retinoic acid (RA)-responsive T-cells in tissues and blood of allogeneic hematopoietic stem-cell transplantation patients and characterized the impact of RA on human T-cell alloresponses.
[Blood]

Abstract

Collagen Promotes Anti-PD-1/PD-L1 Resistance in Cancer through LAIR1-Dependent CD8⁺ T Cell Exhaustion

Collagen-induced T cell exhaustion occured through the receptor LAIR1, which was upregulated following CD18 interaction with collagen, and induced T cell exhaustion through SHP-1.
[Nature Communications]

Full Article

Circulating
T-Cell Immunosenescence in Advanced Non-Small Cell Lung Cancer Patients Treated with Single Agent PD-1/PD-L1 Inhibitors or Platinum-Based Chemotherapy

The percentage of CD28^–, CD57⁺, KLRG1⁺ among CD8⁺ T-cells was assessed by flow cytometry on blood from advanced non-small-cell lung carcinoma patients before single-agent ICI.
[Clinical Cancer Research]

Abstract

IL-17
Sustains the Plasma Cell Response via p38-Mediated Bcl-XL RNA Stability in Lupus Pathogenesis

Using a humanized lupus mouse model, researchers showed that the transfer of Th17 cell-depleted PBMCs from lupus patients resulted in a significantly reduced plasma cell response and attenuated renal damage in recipient mice compared to the transfer of total systemic lupus erythematosus PBMCs.
[Cellular & Molecular Immunology]

Abstract

Autoantibody-Dependent Amplification of Inflammation in SLE

Functional analysis indicated that one subclass of antibodies bound strongly to decondensed DNA areas in neutrophil extracellular traps (NETs) and protected NETs from nuclease digestion, similar to the sera from active SLE patients.
[Cell Death & Disease]

Full Article

HMGB1
Promotes Myeloid Egress and Limits Lymphatic Clearance of Malignant Pleural Effusions

Scientists found that levels of high mobility group box 1 (HMGB1) were equally elevated in both benign and malignant pleural effusions (MPEs) and that limited diversity of T cell receptor expressing gamma and delta chain were inversely associated with these levels in MPEs.
[Frontiers in Immunology]

Full Article

Human CD8⁺
T Cells Exhibit a Shared Antigen Threshold for Different Effector Responses

Using systematic experiments in a reductionist system, in which primary human CD8⁺ T cell blasts were stimulated by recombinant peptides presented on MHC Ag alone, investigators showed that different inflammatory cytokines had comparable Ag dose thresholds across a 25,000-fold variation in affinity.
[Journal of Immunology]

Full Article

Prognostic
Value of Tertiary Lymphoid Structure and Tumor Infiltrating Lymphocytes in Oral Squamous Cell Carcinoma

Associated markers of tertiary lymphoid structures (TLS), including peripheral node address in high endothelial venules, CD20 in B cells and CD3 in T cells, were examined in 168 oral squamous cell carcinoma patients, and survival analysis was performed between TLS-positive and TLS-negative cohorts.
[International Journal of Oral Science]

Full Article

Atypical
Immune Phenotype in Severe Combined Immunodeficiency Patients with Novel Mutations in IL2RG and JAK3

Researchers report clinical course, immunological, genetic and proteomic work-up of two patients with different novel mutations in the IL-2-Janus kinase 3 (JAK3) pathway with a rare atypical presentation of T⁻B⁺NK⁻ severe combined immunodeficiency.
[Genes & Immunity]

Abstract

Resources for Your T Cell Therapy Research

REVIEWS

Exploring the NK Cell Platform for Cancer Immunotherapy

The authors highlight the variety of ways in which diverse NK cell products and their auxiliary therapeutics are being leveraged to target human cancers. They also identify future avenues for NK cell therapy research.
[Nature Reviews Clinical Oncology]

Abstract

INDUSTRY AND POLICY NEWS

ImCheck Achieves Initial Positive Independent Safety Review and Initiates Next Stage of Phase I/IIa EVICTION Trial for ICT01

ImCheck Therapeutics announced that the independent Safety Review Committee for the EVICTION Phase I/II clinical trial for its lead antibody ICT01 unanimously approved dose escalation in the solid tumor indications and the start of enrollment in the two other arms of the study.
[ImCheck Therapeutics]

Press Release

Takeda Opens New R&D Cell Therapy Manufacturing Facility to Support Expansion of Next-Generation Clinical Programs

Takeda Pharmaceutical Company Limited announced the expansion of its cell therapy manufacturing capabilities with the opening of a new 24,000 square-foot R&D cell therapy manufacturing facility at its R&D headquarters in Boston, Massachusetts.
[Takeda Pharmaceutical Company Limited]

Press Release

FEATURED EVENT

Absent B Cells, Agammaglobulinemia, and Hypertrophic Cardiomyopathy in Folliculin Interacting Protein 1 Deficiency

Retinoic Acid-Responsive CD8 Effector T-Cells Are Selectively Increased in IL-23-Rich Tissue in Gastrointestinal GvHD

Collagen Promotes Anti-PD-1/PD-L1 Resistance in Cancer through LAIR1-Dependent CD8⁺ T Cell Exhaustion

Circulating
T-Cell Immunosenescence in Advanced Non-Small Cell Lung Cancer Patients Treated with Single Agent PD-1/PD-L1 Inhibitors or Platinum-Based Chemotherapy

IL-17
Sustains the Plasma Cell Response via p38-Mediated Bcl-XL RNA Stability in Lupus Pathogenesis

Autoantibody-Dependent Amplification of Inflammation in SLE

HMGB1
Promotes Myeloid Egress and Limits Lymphatic Clearance of Malignant Pleural Effusions

Human CD8⁺
T Cells Exhibit a Shared Antigen Threshold for Different Effector Responses

Prognostic
Value of Tertiary Lymphoid Structure and Tumor Infiltrating Lymphocytes in Oral Squamous Cell Carcinoma

Atypical
Immune Phenotype in Severe Combined Immunodeficiency Patients with Novel Mutations in IL2RG and JAK3

Exploring the NK Cell Platform for Cancer Immunotherapy

ImCheck Achieves Initial Positive Independent Safety Review and Initiates Next Stage of Phase I/IIa EVICTION Trial for ICT01

Takeda Opens New R&D Cell Therapy Manufacturing Facility to Support Expansion of Next-Generation Clinical Programs

Immune Responses to Cancer and Infection

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Postdoctoral
Associate – Immune Modulatory Therapies

Postdoctoral Fellowship – Innate Immunity and DNA Repair

Research
Positions – Cancer and Immunotherapy

Podcast
Host – The Immunology Podcast

Postdoctoral Researcher – Immune Oncology

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