 | | Vol. 8.37 – 22 September, 2020 |
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| Investigators established that expression of Death Receptor 3 (DR3), a member of the tumor necrosis factor superfamily, on visceral adipose tissue-derived murine and peripheral blood human group 2 innate lymphoid cells was inducible by IL-33.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| ISG12a was found to be expressed at low levels in gastrointestinal cancer, represented by hepatocellular cancer and gastric cancer, and identified as a tumor suppressor that affects clinical prognosis.
[Cellular & Molecular Immunology] |
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| Researchers developed a novel formula to improve the expansion of peripheral γδ T cells from healthy donors. Then, they used a humanized mouse model to validate the therapeutic efficacy of expanded γδ T cells in vivo; furthermore, the expanded γδ T cells were adoptively transferred into late-stage liver and lung cancer patients.
[Cellular & Molecular Immunology] |
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| The authors explored whether the stability of the IL-10 receptor complex contributed to the immunomodulatory potency of IL-10.
[Science Signaling] |
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| Scientists found that bronchoalveolar lavage fluid exosomes from sarcoidosis patients, but not from healthy individuals, induced a dose-dependent elevation of intracellular IL-1β in monocytes.
[Scientific Reports] |
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| Researchers examined how adaptation of the CSA in combination with multiparametric flow-cytometry may enable simultaneous isolation of multiple, low-frequency, cytokine-secreting cells.
[Scientific Reports] |
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| Scientists collected glomeruli from biopsy specimens from immunoglobulin A nephropathy patients with relatively preserved kidney function and from normal kidney cortices by hand microdissection and performed RNA-seq.
[American Journal of Physiology-Renal Physiology] |
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| Researchers describe how single-domain antibodies (VHH), specific for the human major histocompatibility complex class I-like molecule CD1d, could modulate the function of CD1d-restricted T cells and how one VHH specifically induced strong type I natural killer T (NKT) cell activation.
[Nature Cancer] |
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| Investigators report that omental macrophages promoted the migration and colonization of ovarian cancer cells to the omentum through the secretion of chemokine ligands that interacted with chemokine receptor 1.
[Communications Biology] |
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| The authors describe some of the sensory stimuli that macrophages perceive and the responses they make to various stimuli to achieve their prime directive, which is the maintenance of homeostasis.
[Cellular & Molecular Immunology] |
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| Scientists summarize advances in research on the most prominent immune effectors in cancer and cancer immunotherapy, cytotoxic T cells, and discuss possible implications for future cancer treatment.
[British Journal of Cancer] |
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| ALX Oncology announced it has entered into a clinical trial collaboration with Merck to evaluate the combination of ALX148, an investigational next generation CD47 blocker, and KEYTRUDA®, Merck’s anti-PD-1 therapy, for the treatment of patients with head and neck squamous cell carcinoma.
[ALX Oncology] |
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| | Stockholm University – Stockholm, Sweden |
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| | STEMCELL Technologies – Flexible |
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| | Princess Margaret Cancer Center – Toronto, Ontario, Canada |
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| | Terasaki Research Institute – Los Angeles, California, United States |
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| | Houston Methodist Research Institute – Houston, Texas, United States |
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