 | | Vol. 8.41 – 20 October, 2020 |
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| Through single-cell RNA sequencing, researchers identified the expression of Dach1 and associated genes in this fraction as being coexpressed with myeloid/stem genes but inversely correlated with lymphoid genes.
[Nature Immunology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists determined the impact of tissue plasminogen activator (tPA) on immune cells and investigated the association between observed immune alteration with hemorrhagic transformation in ischemic stroke patients and in a rat model of embolic stroke.
[Circulation Research] |
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| Investigators conducted the first human intervention trial in which urban environmental biodiversity was manipulated to examine its effects on the commensal microbiome and immunoregulation in children.
[Science Advances] |
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| Scientists report that tumor cells embedded in a 3-dimensional collagen gel were killed by cryopreserved natural killer (NK) cells at a 5.6-fold lower rate compared to fresh NK cells.
[Nature Communications] |
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| The authors identified a number of factors that Hofbauer cells (HBCs) secreted that could affect placental angiogenesis and remodeling. They determined that HBCs had the capacity to play a defensive role, where they were responsive to Toll-like receptor stimulation and were microbicidal.
[Journal of Experimental Medicine] |
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| Using mass cytometry, scientists uncovered a naive CD8+ T cell population expressing CD95 that was enriched in patients with high compared with low cardiovascular disease.
[Arteriosclerosis Thrombosis and Vascular Biology] |
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| The authors found that HOPS enhanced NF-κB activation leading to increase transcription of inflammatory mediators, through the reduction of IκBα stability.
[Cell Death & Disease] |
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| Irradiating a co-culture of immature dendritic cells (DCs) and cancer cells exposed to light-activated ZHER2:2395-IR700 enhanced DC maturation, as indicated by augmented expression of CD86 and HLA-DR.
[Cell Death & Disease] |
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| Investigators combined immune landscape signatures with hepatocellular carcinoma clinical and prognostic features to classify them into distinct subtypes. The immunogenomic profiles, stromal cell features and immune cell composition of the subtypes were then systematically analyzed.
[Aging] |
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| Scientists showed that a highly conserved NFAT binding site within the distal noncoding element hHS-8 coordinately controlled TNF and LTA gene expression in human T cells.
[Journal of Immunology] |
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| Researchers showed that cell-free DNA presence and clearance in plasma of healthy individuals played an indispensable role in immune system regulation.
[Scientific Reports] |
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| Scientists identified the landscape of tumor-infiltrating immune cells in the context of long non-coding RNA, known regulators of gene expression. They examined the lncRNA profiles of lung adenocarcinoma tumors by interrogating RNA sequencing data from microdissected and non-microdissected samples.
[Scientific Reports] |
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| Scientists address the latest discoveries around kinase inhibitors with an emphasis on clinically validated autoimmunity and inflammatory pathways.
[Nature Reviews Drug Discovery] |
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| ASLAN Pharmaceuticals announced that it plans to develop ASLAN003, its next generation inhibitor of dihydroorotate dehydrogenase, in autoimmune conditions, such as multiple sclerosis.
[ASLAN Pharmaceuticals] |
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| January 18 – January 20, 2021
Virtual |
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| | H. Lee Moffitt Cancer Center & Research Institute – Tampa, Florida, United States |
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| | Terasaki Research Institute – Los Angeles, California, United States |
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| | Stockholm University – Stockholm, Sweden |
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| | University of California, Davis – Sacramento, California, United States |
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| | Houston Methodist Research Institute – Houston, Texas, United States |
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