 | | Vol. 8.42 – 27 October, 2020 |
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| Using a combination of CyTOF, single-cell RNA sequencing and multiplex immunohistochemistry on patient tumors, matched blood and non-malignant samples, scientists uncovered a complex network of immune-suppressive cellular interactions.
[Nature Cancer] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers present an alternative approach for attenuating cell-surface receptor signaling, termed receptor inhibition by phosphatase recruitment.
[Nature] |
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| Scientists characterized the immunopeptidomes of the two HLA-DR15 allomorphs DR2a and DR2b of human primary B cells and monocytes, thymus, and multiple sclerosis brain tissue.
[Cell] |
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| By whole-exome/genome sequencing, researchers identified heterozygous, autosomal-dominant, germline loss-of-function mutations in the SOCS1 gene in ten patients from five unrelated families with early onset autoimmune manifestations.
[Nature Communications] |
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| To target acute myeloid leukemia (AML) blasts and leukemic stem cells using NK cells, scientists developed a trispecific killer engager molecule containing a humanized anti-CD16 heavy chain camelid single-domain antibody that activates NK cells.
[Leukemia] |
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| The authors investigated the antitumor efficacy of irreversible electroporation plus allogeneic γδ T cells in locally advanced pancreatic cancer patients.
[Signal Transduction and Targeted Therapy] |
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| Researchers found that glioblastoma multiforme-cerebrospinal fluid-exosomes (GBM-CSF-Exos) contained a unique protein, LGALS9 ligand, which bound to the TIM3 receptor of dendritic cells (DCs) in the CSF to inhibit antigen recognition, processing and presentation by DCs, leading to failure of the cytotoxic T-cell-mediated antitumor immune response.
[Cell Death & Disease] |
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| | Investigators hypothesized that gene expression profiling of human melanomas using a new RNA expression technology in formalin-fixed paraffin-embedded tissue would correlate with the same immune cells identified by immunohistochemistry. [Scientific Reports] |
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| Researchers established a novel qPCR methodology incorporating a spike-in calibration curve that expressed cellular kinetics in units of copies/μL blood, as was the case for conventional pharmacokinetic studies of small molecules and other biologics.
[Scientific Reports] |
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| Scientists found that the T cell subsets and inflammatory molecules were not affected by mesenchymal stem cell treatment during the follow-up period. In control patients, a significant decrease was detected only at the Th2 subset, TGF-β1, PGE2, IDO and anti-FcεRI levels on the 14th day of treatment.
[Stem Cell Reviews and Reports] |
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| The authors focus on the causes and consequences of impaired adaptive immunity and discuss therapeutic strategies that can recover immune function, with a particular emphasis on approaches that can promote a diverse repertoire of T cells through de novo T cell formation.
[Nature Reviews Immunology] |
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| Trans-Hit Biomarkers Inc. announced the signing of a partnership agreement with Laboratoires Nexelis Canada Inc. to support prophylactic and therapeutic vaccine development programs sponsored by global pharmaceutical companies, innovative biotechnology companies, and prestigious governmental and non-governmental organizations.
[Trans-Hit Biomarkers, Inc.] |
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| December 2 – December 4
Virtual |
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| | Terasaki Research Institute – Los Angeles, California, United States |
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| | H. Lee Moffitt Cancer Center & Research Institute – Tampa, Florida, United States |
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| | Stockholm University – Stockholm, Sweden |
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| | University of California, Davis – Sacramento, California, United States |
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| | Houston Methodist Research Institute – Houston, Texas, United States |
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