Human Immunology News Volume 8.44 | Nov 10 2020

May 12, 2022

HIN 8.44 | Nov 10 2020

Human Immunology News by STEMCELL Technologies

Vol. 8.44 – 10 November, 2020

TOP STORY

Inhibition of LTβR Signaling Activates WNT-Induced Regeneration in Lung

Scientists demonstrated increased expression of lymphotoxin β-receptor (LTβR) ligands in adaptive and innate immune cells, enhanced non-canonical NF-κB signaling, and enriched LTβR target gene expression in lung epithelial cells from patients with smoking-associated chronic obstructive pulmonary disease.
[Nature]

Full Article

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PUBLICATIONSRanked by the impact factor of the journal

NAD⁺
Metabolism Maintains Inducible PD-L1 Expression to Drive Tumor Immune Evasion

Investigators found nicotinamide phosphoribosyltransferase, the rate-limiting enzyme of the NAD⁺ biogenesis, drove interferon γ-induced PD-L1 expression in multiple types of tumors and governed tumor immune evasion in a CD8⁺ T cell-dependent manner.
[Cell Metabolism]

Abstract Graphical Abstract

Antibody
Binding to Native Cytomegalovirus Glycoprotein B Predicts Efficacy of the GB/MF59 Vaccine in Humans

Scientists investigated the humoral immune correlates of protection from cytomegalovirus (CMV) acquisition in populations of CMV-seronegative adolescent and postpartum women who received the gB/MF59 vaccine.
[Science Translational Medicine]

Abstract

Co-Administered
Antibody Improves Penetration of Antibody–Dye Conjugate into Human Cancers with Implications for Antibody–Drug Conjugates

Researchers report a retrospective exploratory analysis of the trial to evaluate whether co-administration of an unconjugated antibody could improve the intratumoral distribution of the antibody-dye conjugate in patients.
[Nature Communications]

Full Article

Oncolytic
Reovirus (Pelareorep) Induces Autophagy in KRAS-Mutated Colorectal Cancer

The authors explored the effects of pelareorep on autophagy in multiple models of colorectal cancer, including patient derived PBMC.
[Clinical Cancer Research]

Abstract

Novel
Tau Biomarkers Phosphorylated at T181, T217 or T231 Rise in the Initial Stages of the Preclinical Alzheimer’s Continuum When Only Subtle Changes in Aβ Pathology Are Detected

Investigators measured three novel cerebrospinal fluid p‐tau biomarkers, phosphorylated at threonine‐181 and threonine‐217 with an N‐terminal partner antibody and at threonine‐231 with a mid‐region partner antibody.
[EMBO Molecular Medicine]

Full Article

Single-Cell
RNA Sequencing Reveals Heterogeneous Tumor and Immune Cell Populations in Early-Stage Lung Adenocarcinomas Harboring EGFR Mutations

Researchers identified diverse cell types within the tumor microenvironment in which myeloid cells and T cells were the most abundant stromal cell types in tumors and adjacent lung tissues.
[Oncogene]

Full Article

Regulatory
(FoxP3⁺) T Cells and TGF-β Predict the Response to Anti-PD-1 Immunotherapy in Patients with Non-Small Cell Lung Cancer

Scientists investigated the potential correlation between clinical outcomes and peripheral blood immune cell profiles, specifically focused on FoxP3⁺ Treg cells, collected at baseline and one week after anti-PD-1 therapy in two independent cohorts of patients with NSCLC.
[Scientific Reports]

Full Article

Novel
Genetic Risk Factors Influence Progression of Islet Autoimmunity to Type 1 Diabetes

Researchers provided evidence that genetic pathways involved in progression from islet autoimmunity differ from those pathways identified once disease has been established.
[Scientific Reports]

Full Article

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REVIEWS

Glucocorticoids in T Cell Development, Differentiation and Function

Our understanding of glucocorticoid (GC) effects on immunity comes largely from administration of exogenous GCs to treat immune or inflammatory disorders. However, it is increasingly clear that endogenous GCs both promote and suppress T cell immunity.
[Nature Reviews Immunology]

Abstract

Crossing
Boundaries: Interplay between the Immune System and Oligodendrocyte Lineage Cells

The alternative functionality of oligodendroglia not only regulates immune cell responses, but also hinders remyelination, and might thereby be key to understanding MS disease pathology and promoting regeneration after immune-mediated demyelination.
[Seminars in Cell & Developmental Biology]

Full Article

INDUSTRY AND POLICY NEWS

XNK
Therapeutics Receives US Orphan Drug Status for NK Cell-Based Immunotherapy in Multiple Myeloma

XNK Therapeutics AB announced it has received Orphan Drug Designation from the FDA for its leading investigational drug candidate in the treatment of multiple myeloma.
[XNK Therapeutics AB]

Press Release

Intellia
Therapeutics Doses First Patient in Landmark CRISPR/Cas9 Clinical Trial of NTLA-2001 for the Treatment of Transthyretin Amyloidosis

Intellia Therapeutics, Inc. announced that the first patient has been treated with NTLA-2001, which the company is developing as a single-course, potentially curative therapy for transthyretin amyloidosis.
[Intellia Therapeutics, Inc.]

Press Release

FEATURED EVENT

Inhibition of LTβR Signaling Activates WNT-Induced Regeneration in Lung

NAD⁺
Metabolism Maintains Inducible PD-L1 Expression to Drive Tumor Immune Evasion

Antibody
Binding to Native Cytomegalovirus Glycoprotein B Predicts Efficacy of the GB/MF59 Vaccine in Humans

Co-Administered
Antibody Improves Penetration of Antibody–Dye Conjugate into Human Cancers with Implications for Antibody–Drug Conjugates

Oncolytic
Reovirus (Pelareorep) Induces Autophagy in KRAS-Mutated Colorectal Cancer

Novel
Tau Biomarkers Phosphorylated at T181, T217 or T231 Rise in the Initial Stages of the Preclinical Alzheimer’s Continuum When Only Subtle Changes in Aβ Pathology Are Detected

Single-Cell
RNA Sequencing Reveals Heterogeneous Tumor and Immune Cell Populations in Early-Stage Lung Adenocarcinomas Harboring EGFR Mutations

Regulatory
(FoxP3⁺) T Cells and TGF-β Predict the Response to Anti-PD-1 Immunotherapy in Patients with Non-Small Cell Lung Cancer

Novel
Genetic Risk Factors Influence Progression of Islet Autoimmunity to Type 1 Diabetes

Glucocorticoids in T Cell Development, Differentiation and Function

Crossing
Boundaries: Interplay between the Immune System and Oligodendrocyte Lineage Cells

XNK
Therapeutics Receives US Orphan Drug Status for NK Cell-Based Immunotherapy in Multiple Myeloma

Intellia
Therapeutics Doses First Patient in Landmark CRISPR/Cas9 Clinical Trial of NTLA-2001 for the Treatment of Transthyretin Amyloidosis

The American Association for Cancer Research (AACR) Annual Meeting 2021

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Tier 2 Canada Research Chair – Immunology and Inflammation

Research Group Leader – Immunology and Infection

Senior
Scientific Researcher – Immunology Discovery

PhD Student – Adoptive T Cell Therapy of Cancer

Postdoctoral Fellow – Cancer Immunology and Immunotherapy

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