Human Immunology News Volume 8.46 | Nov 24 2020

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    HIN 8.46 | Nov 24 2020


    Human Immunology News by STEMCELL Technologies
    Vol. 8.46 – 24 November, 2020
    TOP STORY

    Defining HPV-Specific B Cell Responses in Patients with Head and Neck Cancer

    Researchers showed that human papillomavirus (HPV)-specific B cell responses were detectable in samples from patients with HPV-positive head and neck cancers, with active production of HPV-specific IgG antibodies in situ.
    [Nature]

    Abstract

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    PUBLICATIONSRanked by the impact factor of the journal

    Neutrophils
    Interact with Cholangiocytes to Cause Cholestatic Changes in Alcoholic Hepatitis

    Liver biopsies from patients with alcoholic hepatitis revealed neutrophils in contact with bile ducts, which correlated with biochemical and histological parameters of cholestasis.
    [Gut]

    Abstract

    Influence
    of Patient Characteristics on Chimeric Antigen Receptor T Cell Therapy in B-Cell Acute Lymphoblastic Leukemia

    Investigators report the outcome of 51 r/r B-ALL patients from a non-randomized, Phase II clinical trial. The primary outcome showed that the overall remission rate was 80.9%.
    [Nature Communications]

    Full Article

    Enhanced
    CAR-T Activity against Established Tumors by Polarizing Human T Cells to Secrete Interleukin-9

    Researchers demonstrated that human CAR-T cells polarized and expanded under a Th9-culture condition have an enhanced antitumor activity against established tumors.
    [Nature Communications]

    Full Article

    Type
    I Interferons Drive the Maturation of Human DC3s with a Distinct Costimulatory Profile Characterized by High GITRL

    The authors used multiparameter flow cytometry and CITE-sequencing to investigate the cell type–specific responses of human peripheral blood dendritic cells and monocyte subsets to type I interferons, focusing on differential regulation of costimulatory molecules.
    [Science Immunology]

    Abstract

    CDK12
    Deficiency and the Immune Microenvironment in Prostate Cancer

    To comprehensively characterize the T-cell immune microenvironment of CDK12-deficient prostate cancers, subsets of immunosuppressive CD4+FOXP3 T-cells were increased compared to CDK12-proficient controls.
    [Clinical Cancer Research]

    Abstract

    Novel
    Neuronal Surface Autoantibodies in Plasma of Patients with Depression and Anxiety

    To study whether neuronal surface autoantibodies were more common in plasma of individuals with depression and anxiety than in controls, plasma samples of 819 individuals with a current diagnosis of depression and/or anxiety, 920 in remission and 492 individuals without these disorders were included in this study.
    [Translational Psychiatry]

    Full Article

    Chemotherapy-Induced Changes in Bronchoalveolar Lavage Fluid CD4+
    and CD8+ Cells of the Opposite Lung to the Cancer

    Researchers explored the effect of chemotherapy on CD4+ and CD8+ cells in the bronchoalveolar lavage fluid of the healthy lung in patients treated with standard chemotherapy regimens.
    [Scientific Reports]

    Full Article

    Integrative
    Tumor and Immune Cell Multi-omic Analyses Predict Response to Immune Checkpoint Blockade in Melanoma

    Investigators analyzed genome-wide sequences and structural alterations with pre- and on-therapy transcriptomic and T cell repertoire features in immunotherapy-naive melanoma patients treated with immune checkpoint blockade.
    [Cell Reports Medicine]

    Full ArticleGraphical Abstract

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    REVIEWS

    Immunopathobiology and Therapeutic Targets Related to Cytokines in Liver Diseases

    Scientists discuss recent data on a large number of cytokines that play important roles in regulating liver injury, inflammation, fibrosis, and regeneration, with a focus on interferons and T helper (Th) 1, Th2, Th9, Th17, interleukin (IL)-1 family, IL-6 family, and IL-20 family cytokines.
    [Cellular & Molecular Immunology]

    Abstract

    Targeting
    Nuclear Acid-Mediated Immunity in Cancer Immune Checkpoint Inhibitor Therapies

    The authors summarized the latest discoveries on the combination of nucleic acid-sensing immunity and immune checkpoint inhibitors in cancer immunotherapy.
    [Signal Transduction and Targeted Therapy]

    Full Article

    INDUSTRY AND POLICY NEWS

    Immunocore’s Tebentafusp Demonstrates Superior Overall Survival Compared to Investigator’s Choice in a Phase III Clinical Trial of Patients with Previously Untreated Metastatic Uveal Melanoma

    Immunocore announced that its Phase III IMCgp100-202 clinical trial of tebentafusp vs. investigator choice in metastatic uveal melanoma has met the pre-defined boundaries for statistical significance of the primary endpoint of Overall Survival in its first pre-planned interim analysis conducted by the independent data monitoring committee.
    [Immunocore]

    Press Release

    FEATURED EVENT

    Cell Symposia: 20 Years of the Human Genome: From Sequence to Substance

    April 11 – April 13, 2021
    San Diego, California, United States


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    JOB OPPORTUNITIES


    Postdoctoral Research Fellow – Immunotherapy

    Fred Hutchinson Cancer Research Center – Seattle, Washington, United States

    Postdoctoral Scholar Position – Immunology and Synthetic Biology

    University of California Irvine – Irvine, California, United States

    Tier 2 Canada Research Chair – Immunology and Inflammation

    Queen’s University – Kingston, Ontario, Canada

    Senior
    Scientific Researcher – Immunology Discovery

    Genentech, Inc. – South San Francisco, California, United States

    PhD Student – Adoptive T Cell Therapy of Cancer

    LMU University Hospital Munich – Munich, Germany

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