| Vol. 8.47 – 1 December, 2020 |
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| Scientists discovered that hepatic B cell lymphopoiesis did not cease after birth and that tolerance defects contributed to immunoglobulin G-autoantibody accumulation in biliary atresia. [Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators showed that Linezolid, a ribosomal-targeting antibiotic, effectively blocked the course of a T cell-mediated autoimmune disease. [Immunity] |
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| Local injections of myeloid cell-targeted STAT3 antisense oligonucleotide activated human DCs/macrophages, promoted CD8 T-cell recruitment and thereby arrested UM-SCC1 tumor growth. [Journal of Clinical Investigation] |
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| The authors showed that in preclinical autoimmunity and established systemic lupus erythematosus, plasmacytoid dendritic cells were not effector cells, had lost capacity for Toll-like-receptor-mediated cytokine production and did not induce T cell activation. [Nature Communications] |
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| Researchers recapitulated the immunosuppression observed in glioblastoma patients in the C57BL/6 mouse and investigated the aetiology of low CD4 T-cell counts. [Brain] |
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| Scientists conducted two clinical trials to verify the safety and efficacy of GC027, an “off-the-shelf” allogeneic CAR-T product targeting T cell antigen CD7. They report two patients as case reports with relapsed/refractory T-ALL who were treated with GC027. [Clinical Cancer Research] |
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| The authors describe a novel function of tumor-associated myeloid cells related to the enhanced breakdown of extracellular hyaluronan (HA) in human bladder cancer tissue, leading to the accumulation of small HA fragments with MW. [Cancer Research] |
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| Food insecurity was associated with increased activation of CD4+ and CD8+ T-cells, increased senescence of CD8+ T-cells, and decreased co-stimulation of CD4+ and CD8+ T-cells. [Clinical Infectious Diseases] |
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| Scientists discuss the roles of immunomodulatory receptors in the control of immunity from a perspective focused on therapeutic potential in not only cancer but also autoimmune diseases. [Cellular & Molecular Immunology] |
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| The liver is an immunologic organ with large populations of innate and innate-like immune cells and is exposed to bacterial, viral, and fungal antigens through the gut–liver axis. Scientists summarize and highlight the role of these cells in liver cancer and propose strategies to therapeutically target them. [Cellular & Molecular Immunology] |
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| Gain Therapeutics, Inc. announced a research collaboration with the University of Maryland School of Medicine, to investigate Gain’s structurally targeted allosteric regulators (STARs) in cellular models of neuronopathic Gaucher disease and Parkinson’s disease. STARs are proprietary small molecules targeting novel allosteric binding sites on enzymes. [Gain Therapeutics, Inc. (Globe Newswire, Inc.)] |
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| May 23 – May 28, 2021 Castelldefels, Spain |
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| The University of British Columbia – Vancouver, British Columbia, Canada |
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| Fred Hutchinson Cancer Research Center – Seattle, Washington, United States |
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| University of California Irvine – Irvine, California, United States |
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| Queen’s University – Kingston, Ontario, Canada |
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| Genentech, Inc. – South San Francisco, California, United States |
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