Human Immunology News Volume 8.47 | Dec 1 2020

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    HIN 8.47 | Dec 1 2020


    Human Immunology News by STEMCELL Technologies
    Vol. 8.47 – 1 December, 2020
    TOP STORY

    Liver
    Immune Profiling Reveals Pathogenesis and Therapeutics for Biliary Atresia

    Scientists discovered that hepatic B cell lymphopoiesis did not cease after birth and that tolerance defects contributed to immunoglobulin G-autoantibody accumulation in biliary atresia.
    [Cell]

    AbstractGraphical Abstract

    Keep current with the latest in infectious disease research.
    PUBLICATIONSRanked by the impact factor of the journal

    Ribosome-Targeting
    Antibiotics Impair T Cell Effector Function and Ameliorate Autoimmunity by Blocking Mitochondrial Protein Synthesis

    Investigators showed that Linezolid, a ribosomal-targeting antibiotic, effectively blocked the course of a T cell-mediated autoimmune disease.
    [Immunity]

    Full ArticleGraphical Abstract

    Myeloid
    Cell-Targeted STAT3 Inhibition Sensitizes Head and Neck Cancers to Radiotherapy and T Cell-Mediated Immunity

    Local injections of myeloid cell-targeted STAT3 antisense oligonucleotide activated human DCs/macrophages, promoted CD8 T-cell recruitment and thereby arrested UM-SCC1 tumor growth.
    [Journal of Clinical Investigation]

    AbstractGraphical Abstract

    Functionally
    Impaired Plasmacytoid Dendritic Cells and Non-Hematopoietic Sources of Type I Interferon Characterize Human Autoimmunity

    The authors showed that in preclinical autoimmunity and established systemic lupus erythematosus, plasmacytoid dendritic cells were not effector cells, had lost capacity for Toll-like-receptor-mediated cytokine production and did not induce T cell activation.
    [Nature Communications]

    Full Article

    Brain
    Cancer Induces Systemic Immunosuppression through Release of Non-Steroid Soluble Mediators

    Researchers recapitulated the immunosuppression observed in glioblastoma patients in the C57BL/6 mouse and investigated the aetiology of low CD4 T-cell counts.
    [Brain]

    Abstract

    Eradication
    of T-ALL Cells by CD7 Targeted Universal CAR-T Cells and Initial Test of Ruxolitinib-Based CRS Management

    Scientists conducted two clinical trials to verify the safety and efficacy of GC027, an “off-the-shelf” allogeneic CAR-T product targeting T cell antigen CD7. They report two patients as case reports with relapsed/refractory T-ALL who were treated with GC027.
    [Clinical Cancer Research]

    Abstract

    Hyal2
    Expression in Tumor-Associated Myeloid Cells Mediates Cancer-Related Inflammation in Bladder Cancer

    The authors describe a novel function of tumor-associated myeloid cells related to the enhanced breakdown of extracellular hyaluronan (HA) in human bladder cancer tissue, leading to the accumulation of small HA fragments with MW. 
    [Cancer Research]

    Abstract

    Food
    Insecurity and T-Cell Dysregulation in Women Living with HIV on Antiretroviral Therapy

    Food insecurity was associated with increased activation of CD4+ and CD8+ T-cells, increased senescence of CD8+ T-cells, and decreased co-stimulation of CD4+ and CD8+ T-cells.
    [Clinical Infectious Diseases]

    Abstract

    New human primary cell products—frozen leukopaks, regulatory T cells, and more. Click to view products.
    REVIEWS

    Novel
    Human Immunomodulatory T Cell Receptors and Their Double-Edged Potential in Autoimmunity, Cardiovascular Disease and Cancer

    Scientists discuss the roles of immunomodulatory receptors in the control of immunity from a perspective focused on therapeutic potential in not only cancer but also autoimmune diseases.
    [Cellular & Molecular Immunology]

    Abstract

    Immunobiology
    and Immunotherapy of HCC: Spotlight on Innate and Innate-Like Immune Cells

    The liver is an immunologic organ with large populations of innate and innate-like immune cells and is exposed to bacterial, viral, and fungal antigens through the gut–liver axis. Scientists summarize and highlight the role of these cells in liver cancer and propose strategies to therapeutically target them.
    [Cellular & Molecular Immunology]

    Abstract

    INDUSTRY AND POLICY NEWS

    Gain Therapeutics and University of Maryland School of Medicine Announce Research Collaboration

    Gain Therapeutics, Inc. announced a research collaboration with the University of Maryland School of Medicine, to investigate Gain’s structurally targeted allosteric regulators (STARs) in cellular models of neuronopathic Gaucher disease and Parkinson’s disease. STARs are proprietary small molecules targeting novel allosteric binding sites on enzymes.
    [Gain Therapeutics, Inc. (Globe Newswire, Inc.)]

    Press Release

    FEATURED EVENT

    Viruses and Cells

    May 23 – May 28, 2021
    Castelldefels, Spain


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    JOB OPPORTUNITIES

    PhD
    Student – RNA Immunoengineering Lab

    The University of British Columbia – Vancouver, British Columbia, Canada


    Postdoctoral Research Fellow – Immunotherapy

    Fred Hutchinson Cancer Research Center – Seattle, Washington, United States

    Postdoctoral Scholar Position – Immunology and Synthetic Biology

    University of California Irvine – Irvine, California, United States

    Tier 2 Canada Research Chair – Immunology and Inflammation

    Queen’s University – Kingston, Ontario, Canada

    Senior
    Scientific Researcher – Immunology Discovery

    Genentech, Inc. – South San Francisco, California, United States

    > See All Jobs

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