Human Immunology News Volume 9.02 | Jan 19 2021

May 12, 2022

HIN 9.02 | Jan 19 2021

Human Immunology News by STEMCELL Technologies

Vol. 9.02 – 19 January, 2021

TOP STORY

Induction
of IL-10-Producing Type 2 Innate Lymphoid Cells by Allergen Immunotherapy Is Associated with Clinical Response

Scientists report a role of interleukin-10-producing type 2 innate lymphoid cells in modulating grass-pollen allergy. They demonstrated that KLRG1⁺ but not KLRG1^– ILC2 produced IL-10 upon activation with IL-33 and retinoic acid.
[Immunity]

Abstract Graphical Abstract

Tools and products for your COVID-19 research.

PUBLICATIONSRanked by the impact factor of the journal

EGR1 Is a Gatekeeper of Inflammatory Enhancers in Human Macrophages

Researchers analyzed the molecular determinants of monocytic and macrophagic commitment by profiling the EGR1 transcription factor. EGR1 is essential for monopoiesis and binds enhancers that regulate monocytic developmental genes such as CSF1R.
[Science Advances]

Full Article

A
Clinically Applicable and Scalable Method To Regenerate T-Cells from iPSCs for Off-the-Shelf T-Cell Immunotherapy

Investigators showed improved differentiation efficiency of T-cells from induced PSCs (iPSCs) derived from an antigen-specific cytotoxic T-cell clone, or from T-cell receptor-transduced iPSCs, as starting materials.
[Nature Communications]

Full Article

Granzyme
B Inhibition Reduces Disease Severity in Autoimmune Blistering Diseases

Scientists explored the role of the immune cell-secreted serine protease, granzyme B, in pemphigoid disease pathogenesis using three independent murine models. In all models, granzyme B knockout or topical pharmacological inhibition significantly reduced total blistering area compared to controls.
[Nature Communications]

Full Article

Human
Intestinal Tissue-Resident Memory T Cells Comprise Transcriptionally and Functionally Distinct Subsets

Researchers investigated transcriptional and functional heterogeneity of human tissue-resident memory T (TRM) cells through study of donor-derived TRM cells from intestinal transplant recipients.
[Cell Reports]

Full Article Graphical Abstract

The
HIV Protease Inhibitor Saquinavir Attenuates Sepsis-Induced Acute Lung Injury and Promotes M2 Macrophage Polarization via Targeting Matrix Metalloproteinase-9

The authors focused on the important role of macrophage polarization in cecal ligation puncture-mediated acute lung injury and determined the ability of saquinavir to maintain M2 over M1 phenotype partially through the inhibition of matrix metalloproteinase-9.
[Cell Death & Disease]

Full Article

Hsa_circ_0007456
Regulates the Natural Killer Cell-Mediated Cytotoxicity toward Hepatocellular Carcinoma via the miR-6852-3p/ICAM-1 Axis

Scientists investigated the relationship between the expression levels of hsa_circ_0007456 in HCC and the susceptibility of NK cells, and found that the expression levels of hsa_circ_0007456 in HCC cell lines significantly influenced their susceptibility to NK cells.
[Cell Death & Disease]

Full Article

Combinatorial
Targeting of Multiple Myeloma by Complementing T Cell Engaging Antibody Fragments

Investigators showed that hemibodies addressing CD38 and SLAMF7 recruited T cells for the exquisite elimination of dual antigen positive multiple myeloma cells while leaving single antigen positive bystanders unharmed.
[Communications Biology]

Full Article

Multi-Level Remodeling of Chromatin Underlying Activation of Human T Cells

To characterize coordinate changes at different levels of chromatin architecture, researchers analyzed chromatin accessibility, chromosome conformation and gene expression in activated human T cells.
[Scientific Reports]

Full Article

Use ImmunoCult™ to differentiate mouse CD4+ cells to Tregs.

REVIEWS

Antitumor Immunity Regulated by Aberrant ERBB Family Signaling

Scientists discuss the mechanisms by which the signaling of ERBB family members affects not only autonomous cancer hallmarks, such as uncontrolled cell proliferation, but also antitumor immune responses in the tumor microenvironment and the potential application of immune-genome precision medicine into immunotherapy.
[Nature Reviews Cancer]

Abstract

Regulation of Immune Responses by the Airway Epithelial Cell Landscape

The authors discuss how the view of the airway epithelial landscape has evolved with the advent of transcriptomic approaches to cellular phenotyping, with a focus on epithelial interactions with the local neuronal and immune systems.
[Nature Reviews Immunology]

Full Article

Nanomaterials for T-Cell Cancer Immunotherapy

Scientists present an overview of nanomaterials that have been used to overcome clinical barriers to T-cell-based immunotherapies and provide their outlook of this emerging field at the interface of cancer immunotherapy and nanomaterial design.
[Nature Nanotechnology]

Full Article

INDUSTRY AND POLICY NEWS

Boehringer Ingelheim and Enara Bio Enter Strategic Collaboration and Licensing Agreement to Discover Novel Shared Antigens for Cancer Immunotherapies

Boehringer Ingelheim and Enara Bio, announced that they have entered into a strategic collaboration and licensing agreement to research and develop novel targeted cancer immunotherapies, leveraging Enara Bio’s Dark Antigen^™ discovery platform.
[Boehringer Ingelheim (BusinessWire, Inc)]

Press Release

FEATURED EVENT

Induction
of IL-10-Producing Type 2 Innate Lymphoid Cells by Allergen Immunotherapy Is Associated with Clinical Response

EGR1 Is a Gatekeeper of Inflammatory Enhancers in Human Macrophages

A
Clinically Applicable and Scalable Method To Regenerate T-Cells from iPSCs for Off-the-Shelf T-Cell Immunotherapy

Granzyme
B Inhibition Reduces Disease Severity in Autoimmune Blistering Diseases

Human
Intestinal Tissue-Resident Memory T Cells Comprise Transcriptionally and Functionally Distinct Subsets

The
HIV Protease Inhibitor Saquinavir Attenuates Sepsis-Induced Acute Lung Injury and Promotes M2 Macrophage Polarization via Targeting Matrix Metalloproteinase-9

Hsa_circ_0007456
Regulates the Natural Killer Cell-Mediated Cytotoxicity toward Hepatocellular Carcinoma via the miR-6852-3p/ICAM-1 Axis

Combinatorial
Targeting of Multiple Myeloma by Complementing T Cell Engaging Antibody Fragments

Multi-Level Remodeling of Chromatin Underlying Activation of Human T Cells

Antitumor Immunity Regulated by Aberrant ERBB Family Signaling

Regulation of Immune Responses by the Airway Epithelial Cell Landscape

Nanomaterials for T-Cell Cancer Immunotherapy

Boehringer Ingelheim and Enara Bio Enter Strategic Collaboration and Licensing Agreement to Discover Novel Shared Antigens for Cancer Immunotherapies

ISSCR: Stem Cells and Global Sustainability

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Postdoctoral Fellow – Tumor Biology and Therapeutic Applications

Senior Laboratory Research Scientist – Cancer Dynamics

Professor or Associate Professor – Rheumatology

Research Scientist – Tumor Microenvironment

Postdoctoral
Associate – Tumor Immune Microenvironment

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