 | | Vol. 9.05 – 9 February, 2021 |
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| Researchers identified double expresser cells by flow cytometry, and found no association between double expresser cell frequency and type 1 diabetes status.
[Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists performed a transcriptomic analysis of the microenvironment of 4,655 DLBCLs from multiple independent cohorts and described four major lymphoma microenvironment categories that associate with distinct biological aberrations and clinical behavior.
[Cancer Discovery] |
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| Chronic graft versus host disease manifestations in mice associated with high BAFF/B cell ratios and persistence of B cell receptor-activated B cells in peripheral blood and lesional tissue.
[Blood] |
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| The up-regulation of laminin γ2 predicted the attenuated efficacy of anti–PD-1 drugs and was associated with unfavorable outcomes in patients with lung cancer or esophageal cancer.
[Science Advances] |
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| Investigators developed an inhibitory feature, achieving a three-input logic, and demonstrated that this programmable system was functional in diverse adaptive and innate immune cells.
[Nature Communications] |
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| The authors showed that PD-1 contributed to the persistence of PD-1+TIM-3+ T cells by binding to the TIM-3 ligand galectin-9 and attenuated Gal-9/TIM-3-induced cell death.
[Nature Communications] |
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| Scientists designed an alternative engager molecule, a bispecific antibody that could simultaneously bind to the Vγ9 chain of the Vγ9Vδ2+ γδ T cell receptor and to AML target antigen, CD123, to selectively recruit Vγ9+ γδ T cells rather than pan T cells to target AML blasts.
[Leukemia] |
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| To understand if polarization of macrophages could lead to a procoagulant macrophage subset, investigators polarized human monocyte derived macrophages to a proinflammatory and an alternative activation state.
[Haematologica] |
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| Researchers combined in vivo and in vitro approaches using primary mouse and human cells, as well as, acute and chronic mouse models of lung inflammation to provide mechanistic insight into the intercellular signaling pathways and mechanisms through which IL-36 promotes lung inflammation.
[Communications Biology] |
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| Scientists evaluated the potential of immunofluorescence-based analysis of 53BP1 expression in differentiating malignant lymphomas from benign lymphoid lesions.
[Scientific Reports] |
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| Investigators identified TCF1 as a transcriptional regulator of pri-miR-181a. A decline in TCF1 levels in old individuals accounted for the reduced miR-181a expression impairing TCR signaling.
[npj Aging and Mechanisms of Disease] |
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| The authors discuss the current understanding of the environmental triggers and genetic predispositions that may lead to B cell acute lymphoblastic leukemia, highlighting lessons from epidemiology, the clinic and animal models, and identifying priority areas for future research.
[Nature Reviews Immunology] |
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| Scientists focus on key findings with respect to the effectiveness of nanomedicine-based cancer immunotherapies and their applications.
[Cancer Gene Therapy] |
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| PDS Biotechnology Corporation announced that the National Cancer Institute’s (NCI) Phase II clinical study of PDS0101 for the treatment of advanced human papillomavirus-associated cancers that have progressed or returned after treatment achieved its preliminary objective response.
[PDS Biotechnology Corporation (Globe Newswire, Inc.)] |
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| March 1 – 2, 2021
Virtual |
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| | University of Washington – Seattle, Washington, United States |
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| | Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States |
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| | Memorial Sloan Kettering Cancer Center – New York, New York, United States |
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| | University of Pennsylvania – Philadelphia, Pennsylvania, United States |
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| | The University of Utah School of Medicine – Salt Lake City, Utah, United States |
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