Human Immunology News Volume 9.06 | Feb 16 2021

May 12, 2022

HIN 9.06 | Feb 16 2021

Human Immunology News by STEMCELL Technologies

Vol. 9.06 – 16 February, 2021

TOP STORY

Inhibitory
CD161 Receptor Identified in Glioma-Infiltrating T Cells by Single-Cell Analysis

Researchers leveraged single-cell RNA sequencing to chart the gene expression and clonal landscape of tumor-infiltrating T cells across 31 patients with isocitrate dehydrogenase (IDH) wild-type glioblastoma and IDH mutant glioma.
[Cell]

Abstract Graphical Abstract

Use ImmunoCult™ to differentiate mouse CD4+ cells to Tregs.

PUBLICATIONSRanked by the impact factor of the journal

TCR-Engineered
T Cells Targeting E7 for Patients with Metastatic HPV-Associated Epithelial Cancers

Scientists conducted a first-in-human, Phase I clinical trial of T cells engineered with a T cell receptor targeting HPV-16 E7 for the treatment of metastatic human papilloma virus-associated epithelial cancers.
[Nature Medicine]

Abstract

Tumor
Hypoxia Represses γδ T Cell-Mediated Antitumor Immunity against Brain Tumors

The authors discovered that brain tumor cells had a particularly high demand for oxygen, which affected γδ T cell-mediated antitumor immune responses but not those of conventional T cells.
[Nature Immunology]

Abstract

Single-Cell
Analysis of Human B Cell Maturation Predicts How Antibody Class Switching Shapes Selection Dynamics

Investigators provide a comprehensive roadmap of human B cell maturation with single-cell transcriptomics matched with bulk and single-cell antibody repertoires to define gene expression, antibody repertoires, and clonal sharing of B cell states at single-cell resolution.
[Science Immunology]

Abstract

LincRNA-Immunity
Landscape Analysis Identifies EPIC1 as a Regulator of Tumor Immune Evasion and Immunotherapy Resistance

Immunocompetent mouse models and in vitro co-culture assays demonstrated that EPIC1 induced tumor immune evasion and resistance to immunotherapy by suppressing tumor cell antigen presentation.
[Science Advances]

Full Article

Arachidonic
Acid-Regulated Calcium Signaling in T Cells from Patients with Rheumatoid Arthritis Promotes Synovial Inflammation

Scientists showed that CD4⁺ T cells from patients with rheumatoid arthritis and psoriatic arthritis had increased expression of the pore-forming calcium channel component ORAI3.
[Nature Communications]

Full Article

Prostaglandin I₂
Signaling Licenses Treg Suppressive Function and Prevents Pathogenic Reprogramming

Using fate-mapping mice, researchers reported that prostaglandin I₂ signaling prevented Treg reprogramming toward a pathogenic phenotype.
[Journal of Clinical Investigation]

Abstract Full Article
Graphical Abstract

Analysis
of Classical Neutrophils and Polymorphonuclear Myeloid-Derived Suppressor Cells in Cancer Patients and Tumor-Bearing Mice

Using single-cell RNA-seq, cell mass spectrometry, flow cytometry, and functional analysis, investigators characterized the heterogeneity of polymorphonuclear neutrophils in cancer.
[Journal of Experimental Medicine]

Abstract

The
IKZF1-IRF4/IRF5 Axis Controls Polarization of Myeloma-Associated Macrophages

Scientists observed that myeloma-associated macrophages derived from patients treated with the immunomodulatory drug lenalidomide skewed phenotypically and functionally toward an M1 phenotype.
[Cancer Immunology Research]

Abstract

Alterations
of 5-Hydroxymethylation in Circulating Cell-Free DNA Reflect Molecular Distinctions of Subtypes of Non-Hodgkin Lymphoma

The authors profiled genome-wide 5-methylcytosines in circulating cell-free DNA from 73 newly diagnosed patients with diffuse large B-cell lymphoma and follicular lymphoma.
[npj Genomic Medicine]

Full Article

Modulatory Activity of Adenosine on the Immune Response in Cord and Adult Blood

Impact of adenosine on peripheral and cord blood mononuclear cells was analyzed by quantification of ectonucleotidases and adenosine receptor expression.
[Pediatric Research]

Abstract

Single-Cell
Analysis Shows That Adipose Tissue of Persons with Both HIV and Diabetes Is Enriched for Clonal, Cytotoxic, and CMV-Specific CD4⁺ T Cells

Persons with HIV and diabetes have a high proportion of CX3CR1⁺ GPR56+ CD57⁺ CD4⁺ T cells in adipose tissue, a subset of which were cytomegalovirus specific, whereas individuals with diabetes but without HIV had predominantly CD69⁺ CD4⁺ T cells.
[Cell Reports Medicine]

Full Article Graphical Abstract

Resources for Your T Cell Therapy Research

REVIEWS

Intratumoral Heterogeneity in Cancer Progression and Response to Immunotherapy

Scientists discuss the main sources of intratumoral heterogeneity and its impact on the natural history of the disease, including sensitivity to treatment, as they delineate potential strategies to target such a detrimental feature of aggressive malignancies.
[Nature Medicine]

Abstract

Astrocyte-Immune Cell Interactions in Physiology and Pathology

The authors review the current understanding of astrocyte interactions with microglia and the vasculature and protective barriers in the central nervous system as well as highlight recent insights into physiologic and reactive astrocyte sub-states identified by transcriptional profiling.
[Immunity]

Abstract

INDUSTRY AND POLICY NEWS

AIM ImmunoTech Announces the Expansion of its Pancreatic Cancer Program to Include New Patients in the Netherlands

AIM ImmunoTech, Inc. announced that the Dutch Health and Youth Care Inspectorate has approved treatment for six pancreatic cancer patients as part of a new, follow-up Early Access Program at Erasmus Medical Center in the Netherlands.
[AIM ImmunoTech, Inc.]

Press Release

FEATURED EVENT

Inhibitory
CD161 Receptor Identified in Glioma-Infiltrating T Cells by Single-Cell Analysis

TCR-Engineered
T Cells Targeting E7 for Patients with Metastatic HPV-Associated Epithelial Cancers

Tumor
Hypoxia Represses γδ T Cell-Mediated Antitumor Immunity against Brain Tumors

Single-Cell
Analysis of Human B Cell Maturation Predicts How Antibody Class Switching Shapes Selection Dynamics

LincRNA-Immunity
Landscape Analysis Identifies EPIC1 as a Regulator of Tumor Immune Evasion and Immunotherapy Resistance

Arachidonic
Acid-Regulated Calcium Signaling in T Cells from Patients with Rheumatoid Arthritis Promotes Synovial Inflammation

Prostaglandin I₂
Signaling Licenses Treg Suppressive Function and Prevents Pathogenic Reprogramming

Analysis
of Classical Neutrophils and Polymorphonuclear Myeloid-Derived Suppressor Cells in Cancer Patients and Tumor-Bearing Mice

The
IKZF1-IRF4/IRF5 Axis Controls Polarization of Myeloma-Associated Macrophages

Alterations
of 5-Hydroxymethylation in Circulating Cell-Free DNA Reflect Molecular Distinctions of Subtypes of Non-Hodgkin Lymphoma

Modulatory Activity of Adenosine on the Immune Response in Cord and Adult Blood

Single-Cell
Analysis Shows That Adipose Tissue of Persons with Both HIV and Diabetes Is Enriched for Clonal, Cytotoxic, and CMV-Specific CD4⁺ T Cells

Intratumoral Heterogeneity in Cancer Progression and Response to Immunotherapy

Astrocyte-Immune Cell Interactions in Physiology and Pathology

AIM ImmunoTech Announces the Expansion of its Pancreatic Cancer Program to Include New Patients in the Netherlands

ACCR: Radiation Science and Medicine

> See All Events

Postdoctoral Fellow – Immunogenetics and Tumor Immunology

Postdoctoral Associate Position – Tumor Immunology/Immunotherapy

Postdoctoral
Scholar – Immune Responses in Human Skin and Mucosal Surfaces

Postdoctoral
Fellow – Osteoarthritis

Postdoctoral Fellowship – Human Cancers

> See All Jobs