 | | Vol. 9.07 – 23 February, 2021 |
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| Scientists report that patients with low melanoma neoantigen burdens who responded to immune checkpoint inhibitors had tumors with higher expression of pigmentation-related genes.
[Science Translational Medicine] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Ex vivo, hypomethylating agents enhanced primary human CD8+ T cell activation markers, effector cytokine production, and anti-tumor cytolytic activity.
[Molecular Cell] |
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| Investigators describe the results from a Phase Ib clinical trial in which 17 patients with locally advanced head and neck squamous cell carcinoma received a murine anti-human OX40 agonist antibody prior to definitive surgical resection.
[Nature Communications] |
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| Scientists analyzed Treg clonal origin in breast cancer patients using T-Cell Receptor and single-cell transcriptome sequencing.
[Nature Communications] |
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| To better understand the roles of intratumoral Tregs, the authors selectively depleted tumor-infiltrating T regulatory cells using anti-CD25-F(ab′)2 near-infrared photoimmunotherapy.
[Cancer Research] |
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| SLAMF7 expression associated with T cell exhaustion surface markers and exhaustion-related transcription factor signatures. T cells from patients with a high frequency of SLAMF7+CD8+ T cells exhibited decreased immunoreactivity towards the MART-1aa26–35*A27L antigen.
[Leukemia] |
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| Researchers assessed the preclinical efficacy of epcoritamab against primary tumor cells present in the lymph node biopsies from newly diagnosed and relapsed/refractory B-cell non-Hodgkin lymphoma patients.
[Blood Cancer Journal] |
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| The authors showed that in hepatocellular carcinoma tumors the highest expression level of hexokinase 2 was inversely correlated to glucokinase expression, and was associated to poor prognosis for patient survival.
[Communications Biology] |
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| Scientists used a multi-omics approach to identify mechanisms driving the transcriptional abnormalities in peripheral blood CD4+ T cells of children with active juvenile idiopathic arthritis.
[Scientific Reports] |
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| Investigators demonstrated that the overexpression of c-Myb and FoxM1 was responsible for the synergistic activation of the WNT5A promoter.
[Scientific Reports] |
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| Scientists review the current understanding of the diverse effects that inflammasomes can have on adaptive responses, beginning with the fate of antigen released from pyroptotic cells, followed by consideration of the effects of inflammasome-dependent cytokines in infection, cancer and autoimmune disease.
[Nature Immunology] |
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| The authors discuss well-studied chemokine receptors that regulate migration of effector and immunosuppressive immune cells in the context of cancer immunology.
[Cancer Gene Therapy] |
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| AIM ImmunoTech, Inc. announced that the Dutch Health and Youth Care Inspectorate has approved treatment for six pancreatic cancer patients as part of a new, follow-up Early Access Program at Erasmus Medical Center in the Netherlands.
[AIM ImmunoTech, Inc.] |
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| | University of Basel – Basel, Switzerland |
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| | Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States |
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| | The University of Texas Southwestern Medical Center – Dallas, Texas, United States |
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| | Duke University – Durham, North Carolina, United States |
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| | Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States |
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