Human Immunology News Volume 9.08 | Mar 2 2021

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    HIN 9.08 | Mar 2 2021


    Human Immunology News by STEMCELL Technologies
    Vol. 9.08 – 2 March, 2021
    TOP STORY

    Affinity-Matured Hla Class II Dimers for Robust Staining of Antigen-Specific CD4+ T Cells

    Researchers produced affinity-matured class II dimers that stain antigen-specific T cells better than conventional multimers in both in vitro and ex vivo analyses.
    [Nature Biotechnology]

    Abstract

    Start Fast. Finish Faster. Streamline your assays with purified human primary cells from STEMCELL Technologies. View products now.
    PUBLICATIONSRanked by the impact factor of the journal

    Multimodal Pooled Perturb-Cite-Seq Screens in Patient Models Define Mechanisms of Cancer Immune Evasion

    In patient-derived melanoma cells and autologous tumor-infiltrating lymphocyte co-cultures, scientists profiled transcriptomes and 20 proteins in ~218,000 cells under ~750 perturbations associated with cancer cell-intrinsic immune checkpoint inhibitor resistance.
    [Nature Genetics]

    Abstract

    Sialic Acids in Pancreatic Cancer Cells Drive Tumor-Associated Macrophage Differentiation via the Siglec Receptors Siglec-7 and Siglec-9

    Investigators showed that PDAC tumor cells present an increased sialylation that could be recognized by Siglec-7 and Siglec-9 on myeloid cells.
    [Nature Communications]

    Full Article

    Proteolysis-Targeting Chimera against BCL-XL Destroys Tumor-Infiltrating Regulatory T Cells

    The authors report their discovery of B-cell lymphoma extra-large as a potential molecular target of tumor-infiltrating Tregs.
    [Nature Communications]

    Full Article

    CRISPR/Cas9-Engineered Universal CD19/CD22 Dual-Targeted CAR-T Cell Therapy for Relapsed/Refractory B-Cell Acute Lymphoblastic Leukemia

    Scientists developed CRISPR-edited universal off-the-shelf CD19/CD22 dual-targeted CAR-T cells as a novel therapy for relapsed/refractory acute lymphoblastic leukemia.
    [Clinical Cancer Research]

    Abstract

    CD20 as a Gatekeeper of the Resting State of Human B Cells

    Researchers demonstrated that CD20 controlled the nanoscale organization of receptors on the surface of resting B lymphocytes.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Full Article

    Modified Hypoxia-Inducible Factor Expression in CD8+ T Cells Increases Antitumor Efficacy

    Investigators undertook experiments to define structural determinants of hypoxia-inducible factor that potentiate antitumor efficacy in cytotoxic T cells.
    [Cancer Immunology Research]

    Abstract

    IRF4 Modulates the Response to BCR Activation in Chronic Lymphocytic Leukemia Regulating IKAROS and SYK

    Scientists modulated interferon regulatory factor 4 (IRF4) levels by transfecting chronic lymphocytic leukemia cells with an IRF4 vector or by silencing using small-interfering RNAs.
    [Leukemia]

    Full Article

    High miR-451 Expression in Peripheral Blood Mononuclear Cells from Subjects at Risk of Developing Rheumatoid Arthritis

    The authors identified differentially expressed miRNAs in the peripheral blood of anti-citrullinated protein antibodies (ACPA)-positive individuals with arthralgia at risk of rheumatoid arthritis compared to healthy controls.
    [Scientific Reports]

    Full Article

    Cholesterol Loading Suppresses the Atheroinflammatory Gene Polarization of Human Macrophages Induced by Colony Stimulating Factors

    Researchers generated human macrophages in the presence of either macrophage-colony stimulating factor or granulocyte–macrophage-colony stimulating factor to obtain M-MØ and GM-MØ.
    [Scientific Reports]

    Full Article

    Explore scientific events this March with the Science Events Calendar.
    REVIEWS

    Targeting Tumor-Associated Macrophages to Synergize Tumor Immunotherapy

    Scientists summarize recent studies investigating the involvement of TAMs in immune checkpoint inhibition, tumor vaccines and adoptive cell transfer therapies.
    [Signal Transduction and Targeted Therapy]

    Full Article

    Transcriptional Regulatory Network for the Establishment of CD8+ T Cell Exhaustion

    The authors summarize the recent discoveries that have deepened our understanding of the exhaustion program of cytotoxic CD8+ T cells.
    [Experimental and Molecular Medicine]

    Full Article

    INDUSTRY AND POLICY NEWS

    MaxiVAX and Minaris Regenerative Medicine Enter into a Manufacturing Partnership for MVX-ONCO-2 Cancer Immunotherapy

    MaxiVAX SA and Minaris Regenerative Medicine GmbH have entered into a manufacturing agreement for MVX-ONCO-2, a cell-based immunotherapy for the treatment of cancers such as chordoma, head and neck, and other solid tumors.
    [MaxiVAX SA]

    Press Release

    FEATURED EVENT

    FcRn-Targeted Therapies for Autoimmune Disorders

    March 23 – 25, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Myeloid-Derived Suppressor Cells

    Houston Methodist Research Institute – Houston, Texas, United States

    Postdoctoral Position – Cancer Immunotherapy

    University of Notre Dame – Notre Dame, Indiana, United States

    Postdoctoral Fellow – Human COVID Immunology

    Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States

    Postdoctoral Fellow – Immunogenetics and Tumor Immunology

    The University of Texas Southwestern Medical Center – Dallas, Texas, United States

    Postdoctoral Fellow – Osteoarthritis

    Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States

    > See All Jobs

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