Human Immunology News Volume 9.09 | Mar 9 2021

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    HIN 9.09 | Mar 9 2021


    Human Immunology News by STEMCELL Technologies
    Vol. 9.09 – 9 March, 2021
    TOP STORY

    A Burned-Out CD8+ T-Cell Subset Expands in the Tumor Microenvironment and Curbs Cancer Immunotherapy

    Using a humanized patient-derived tumor xenograft model, investigators demonstrated that a burned-out CD8+ tumor infiltrating lymphocyte subset expansion occurred within the tumor microenvironment.
    [Cancer Discovery]

    Abstract

    Use EasySep to isolate highly purified immune cells in as little as 8 minutes.
    PUBLICATIONSRanked by the impact factor of the journal

    Cytoplasmic DNA Sensing by KU Complex in Aged CD4+ T Cell Potentiates T Cell Activation and Aging-Related Autoimmune Inflammation

    Scientists found KU complex abundantly expressed in the cytoplasm, where it recognized accumulated cytoplasmic DNA in aged human and mouse CD4+ T cells.
    [Immunity]

    AbstractGraphical Abstract

    Wnt–β-Catenin Activation Epigenetically Reprograms Treg Cells in Inflammatory Bowel Disease and Dysplastic Progression

    Researchers showed progressive expansion of RORγt+ regulatory T cells in individuals with inflammatory bowel disease during inflammation and early dysplasia.
    [Nature Immunology]

    Abstract

    Bispecific Antibodies Targeting Mutant Ras Neoantigens

    Using phage display, the authors isolated single-chain variable fragments specific for each mutant peptide-HLA complexes.
    [Science Immunology]

    Full Article

    The Neutrophil Antimicrobial Peptide Cathelicidin Promotes Th17 Differentiation

    Investigators report that cathelicidin was a powerful Th17 potentiator which enhanced aryl hydrocarbon receptor (AHR) and RORγt expression, in a TGF-β1-dependent manner.
    [Nature Communications]

    Full Article

    Virus-Specific Memory T Cell Responses Unmasked by Immune Checkpoint Blockade Cause Hepatitis

    Scientists identified a subset of patients predisposed to immune checkpoint blockade-related hepatitis who were distinguished by chronic expansion of effector memory CD4+ T cells.
    [Nature Communications]

    Full Article

    Immune Cell Constitution in the Tumor Microenvironment Predicts the Outcome in Diffuse Large B-Cell Lymphoma

    Investigators profiled the expression of 730 immune-related genes in tumor tissues of 81 patients with diffuse large B-cell lymphoma utilizing the Nanostring platform, and used multiplex immunohistochemistry to characterize T-cell phenotypes.
    [Haematologica]

    Full Article

    Human Leukocyte Antigen-G Upregulates Immunoglobulin-Like Transcripts and Corrects Dysfunction of Immune Cells in Immune Thrombocytopenia

    Researchers observed significantly less human leukocyte antigen-G in plasma from immune thrombocytopenia patients positive for anti-platelet autoantibodies compared with autoantibodies-negative patients or healthy controls.
    [Haematologica]

    Full Article

    Circulating CD103+ γδ and CD8+ T Cells Are Clonally Shared with Tissue-Resident Intraepithelial Lymphocytes in Celiac Disease

    Scientists obtained γδ and αβ TCR sequences of >2500 single cells from blood and gut of five patients, before and during challenge. They observed extensive sharing between blood and gut γδ and CD8+ αβ T-cell clonotypes even prior to gluten challenge.
    [Mucosal Immunology]

    Abstract

    Robust Anti-Tumor Activity and Low Cytokine Production by Novel Humanized Anti-CD19 CAR-T Cells

    Researchers designed a novel humanized anti-CD19 CAR-T cells by humanizing the framework region of scFv derived from a murine FMC63 mAb and combining it with CD8a transmembrane domain, 4-1BB costimulatory domain and CD3ζ signaling domain.
    [Molecular Cancer Therapeutics]

    Abstract

    Hepatic Lymphocytes Involved in the Pathogenesis of Pediatric and Adult Non-Alcoholic Fatty Liver Disease

    To characterize liver pathogenesis in pediatric and adult cases, frequency and localization of immune cell populations were evaluated.
    [Scientific Reports]

    Full Article

    Associations of Serum Short-Chain Fatty Acids with Circulating Immune Cells and Serum Biomarkers in Patients with Multiple Sclerosis

    Levels of serum short-chain fatty acids were correlated with immune cell abundance and phenotype as well as with other relevant serum factors in blood samples taken at first presentation of Clinically Isolated Syndrome or MS and compared to healthy controls.
    [Scientific Reports]

    Full Article

    The STEMdiffâ„¢ Monocyte Kit generates millions of monocytes ready for downstream assays or further development into macrophages or dendritic cells.
    REVIEWS

    Beyond Immune Checkpoint Blockade: Emerging Immunological Strategies

    Scientists review the history of immunotherapy and checkpoint blockade, highlighting important clinical failures.
    [Nature Reviews Drug Discovery]

    Abstract

    Electroimmunology and Cardiac Arrhythmia

    The authors summarize the interactions between immune cells and neural systems that influence information transfer, extrapolating findings from the field of neuroscience to the heart and defining common themes.
    [Nature Reviews Cardiology]

    Abstract

    Targeted Based Therapy in Nodal T-cell Lymphomas

    Investigators summarize the status and the current role of targeted-based therapy in nodal T-cell lymphomas.
    [Leukemia]

    Abstract

    INDUSTRY AND POLICY NEWS

    Lilly and Biolojic Design Announce Research Collaboration to Discover and Develop Antibody Therapies for Diabetes

    Eli Lilly and Company and Biolojic Design Ltd. announced a research collaboration and license agreement that will leverage Biolojic’s AI-based multibody platform to discover and develop a potential novel antibody-based therapy for the treatment of diabetes.
    [Eli Lilly and Company]

    Press Release

    FEATURED EVENT

    Lipidomics of Health and Disease

    March 24 – 26, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow Position – B Cell Biology

    University of Toronto – Toronto, Canada

    Research Fellow – RNA Biology

    Dana-Farber Cancer Institute – Boston, Massachusetts, United States

    Postdoc/Research Scientist – Immunology

    H. Lee Moffitt Cancer Center & Research Institute – Tampa, Florida, United States

    Postdoctoral Fellow – Human COVID Immunology

    Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States

    Postdoctoral Fellow – Osteoarthritis

    Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States

    > See All Jobs

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