| Vol. 9.09 – 9 March, 2021 |
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| Using a humanized patient-derived tumor xenograft model, investigators demonstrated that a burned-out CD8+ tumor infiltrating lymphocyte subset expansion occurred within the tumor microenvironment. [Cancer Discovery] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists found KU complex abundantly expressed in the cytoplasm, where it recognized accumulated cytoplasmic DNA in aged human and mouse CD4+ T cells. [Immunity] |
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| Researchers showed progressive expansion of RORγt+ regulatory T cells in individuals with inflammatory bowel disease during inflammation and early dysplasia. [Nature Immunology] |
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| Using phage display, the authors isolated single-chain variable fragments specific for each mutant peptide-HLA complexes. [Science Immunology] |
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| Investigators report that cathelicidin was a powerful Th17 potentiator which enhanced aryl hydrocarbon receptor (AHR) and RORγt expression, in a TGF-β1-dependent manner. [Nature Communications] |
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| Scientists identified a subset of patients predisposed to immune checkpoint blockade-related hepatitis who were distinguished by chronic expansion of effector memory CD4+ T cells. [Nature Communications] |
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| Investigators profiled the expression of 730 immune-related genes in tumor tissues of 81 patients with diffuse large B-cell lymphoma utilizing the Nanostring platform, and used multiplex immunohistochemistry to characterize T-cell phenotypes. [Haematologica] |
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| Researchers observed significantly less human leukocyte antigen-G in plasma from immune thrombocytopenia patients positive for anti-platelet autoantibodies compared with autoantibodies-negative patients or healthy controls. [Haematologica] |
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| Scientists obtained γδ and αβ TCR sequences of >2500 single cells from blood and gut of five patients, before and during challenge. They observed extensive sharing between blood and gut γδ and CD8+ αβ T-cell clonotypes even prior to gluten challenge. [Mucosal Immunology] |
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| Researchers designed a novel humanized anti-CD19 CAR-T cells by humanizing the framework region of scFv derived from a murine FMC63 mAb and combining it with CD8a transmembrane domain, 4-1BB costimulatory domain and CD3ζ signaling domain. [Molecular Cancer Therapeutics] |
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| To characterize liver pathogenesis in pediatric and adult cases, frequency and localization of immune cell populations were evaluated. [Scientific Reports] |
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| Levels of serum short-chain fatty acids were correlated with immune cell abundance and phenotype as well as with other relevant serum factors in blood samples taken at first presentation of Clinically Isolated Syndrome or MS and compared to healthy controls. [Scientific Reports] |
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| Scientists review the history of immunotherapy and checkpoint blockade, highlighting important clinical failures. [Nature Reviews Drug Discovery] |
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| The authors summarize the interactions between immune cells and neural systems that influence information transfer, extrapolating findings from the field of neuroscience to the heart and defining common themes. [Nature Reviews Cardiology] |
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| Investigators summarize the status and the current role of targeted-based therapy in nodal T-cell lymphomas. [Leukemia] |
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| Eli Lilly and Company and Biolojic Design Ltd. announced a research collaboration and license agreement that will leverage Biolojic’s AI-based multibody platform to discover and develop a potential novel antibody-based therapy for the treatment of diabetes. [Eli Lilly and Company] |
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| March 24 – 26, 2021 Virtual |
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| University of Toronto – Toronto, Canada |
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| Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
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| H. Lee Moffitt Cancer Center & Research Institute – Tampa, Florida, United States |
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| Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States |
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| Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States |
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