 | | Vol. 9.10 – 16 March, 2021 |
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| The authors characterized the single-cell transcriptomes of cancer and immune cells from metastatic renal cell carcinoma patients before or after immune checkpoint blockade exposure.
[Cancer Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| To understand the metabolic state of rare, early-activated T cells, scientists adapted mass cytometry to quantify metabolic regulators at single-cell resolution in parallel with cell signaling, proliferation, and effector function.
[Immunity] |
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| Investigators describe an approach to target T cell cancers through T cell receptor (TCR) antigens. Each T cell, normal or malignant, expressed a unique TCR β chain generated from 1 of 30 TCR β chain variable gene families.
[Science Translational Medicine] |
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| Scientists combined single-cell RNA-sequencing and multiparameter flow cytometry to assess changes in circulating CD8+ T cells in 28 patients with metastatic melanoma starting anti-PD-1 therapy.
[Nature Communications] |
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| The authors found T-cell exhaustion linked to overall survival in 675 hepatocellular carcinoma patients with diverse ethnicities and etiologies.
[Nature Communications] |
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| Researchers qualitatively and quantitatively studied the main players in PINK1-mediated mitophagy in peripheral blood mononuclear cells of patients with relapsing–remitting multiple sclerosis.
[Cell Death & Differentiation] |
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| Researchers demonstrated that interleukin-32 (IL-32) expression was significantly upregulated in syncytiotrophoblasts and that IL-32β was the major isoform with increased expression in the placenta of severe preeclampsia patients.
[Cellular & Molecular Immunology] |
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| Researchers identified effector memory CD4+ T cells and CD4–CD8low/-CD161+ T cells, specifically those positive for the chemokine receptor CCR6, as the circulating immune subtypes with the greatest response to IL-1β.
[Science Signaling] |
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| Nucleotide-binding domain–like receptor protein 3 (NLRP3) knockout and rescue experiments demonstrated that NLRP3 participated in protectin DX-mediated Treg/Th17 cell balance restoration, joint injury amelioration and inflammatory-response attenuation using Nlrp3-/- mice.
[Cell Death & Disease] |
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| PI3K∂ blockade by idelalisib reduced the expression levels of inhibitory checkpoint molecules in T cells isolated from both healthy donors and chronic lymphocytic leukemia patients.
[Frontiers in Immunology] |
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| Scientists hypothesized that adding acetylsalicylic acid and low-dose interleukin-2 would increase the vaccine efficacy in a recurrent advanced ovarian cancer Phase I trial.
[npj Vaccines] |
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| Researchers studied the proportion of different B cell subsets and their capacity to secrete IL-10 ex vivo in peripheral blood from patients with or without chronic Chagas disease cardiomyopathy.
[Scientific Reports] |
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| Scientists review the tumor-derived factors modulating dendritic cell function.
[Nature Reviews Cancer] |
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| The authors review the underlying immunological basis of various asthma endotypes by discussing results obtained from animal studies as well as results generated in clinical studies targeting specific immune pathways.
[Cell] |
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| Scientists cover the mechanisms of NLRP3 inflammasome activation and its divergent roles in the pathogenesis of inflammation-associated diseases such as cancer, atherosclerosis, diabetes and obesity
[Nature Immunology] |
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| 108Labs announced the discovery of novel secretory antibody biosynthesis in the development of Colostrupedicsâ„¢ whole-human infant formula, the first animal-free infant formula exclusively comprising cell-cultured human milk molecules derived from human mammary cell agriculture and formulated with broadly-neutralizing human secretory antibodies.
[108Labs (Life Science Newswire, Inc.)] |
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| Pathios Therapeutics will team up with researchers at The University of Oxford to accelerate cancer immunotherapies targeting GPR65 on immunosuppressive macrophages
[Pathios Therapeutics (Life Science Newswire, Inc.)] |
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| March 25 – 26, 2021
Virtual |
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| | Translate Bio – Lexington, Massachusetts, United States |
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| | University of Toronto – Toronto, Canada |
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| | Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
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| | H. Lee Moffitt Cancer Center & Research Institute – Tampa, Florida, United States |
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| | Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States |
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