Human Immunology News Volume 9.11 | Mar 23 2021

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    HIN 9.11 | Mar 23 2021


    Human Immunology News by STEMCELL Technologies
    Vol. 9.11 – 23 March, 2021
    TOP STORY

    B Cell-Specific XIST Complex Enforces X-Inactivation and Restrains Atypical B Cells

    Investigators showed XIST was continually required in adult human B cells to silence a subset of X-linked immune genes such as TLR7.
    [Cell]

    AbstractGraphical Abstract

    Find the Right Antibodies for Your Stem Cell Research. Learn More
    PUBLICATIONSRanked by the impact factor of the journal

    Extracellular Vesicle Drug Occupancy Enables Real-Time Monitoring of Targeted Cancer Therapy

    Scientists developed an analytical platform that leverages circulating extracellular vesicles for activity-based assessment of tumor-specific drug–target interactions in patient blood samples.
    [Nature Nanotechnology]

    Abstract

    Implication of TIGIT+ Human Memory B Cells in Immune Regulation

    T cell immunoreceptor with Ig and ITIM domains (TIGIT) on memory B cells controlled immune response by directly acting on T cells and by arresting proinflammatory function of dendritic cells.
    [Nature Communications]

    Full Article

    The Hedgehog Pathway Suppresses Neuropathogenesis in CD4 T Cell-Driven Inflammation

    Researchers showed that the CNS-endogenous hedgehog pathway attenuated the pathogenicity of human and mouse effector CD4 T cells by regulating their production of inflammatory cytokines.
    [Brain]

    Abstract

    Involvement of Cytotoxic Eomes-Expressing CD4+ T Cells in Secondary Progressive Multiple Sclerosis

    Few Eomes+ T helper cells (Th) cells circulate in relapsing-remitting multiple sclerosis (MS) patient peripheral blood, primary progressive MS patients, or healthy controls, but Eomes+ Th cells were significantly increased in secondary progressive MS.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Full Article

    Acetylcholine Ameliorates Colitis by Promoting IL-10 Secretion of Monocytic Myeloid-Derived Suppressor Cells through the nAChR/ERK Pathway

    By using the xCell tool and the latest immunolabeling-enabled 3D imaging of solvent-cleared organs technique, scientists found severe pathological damage of the entire enteric nervous system and decreased expression of choline acetyltransferase in inflammatory bowel disease patients.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    EOMES Is Essential for Antitumor Activity of CD8+ T Cells in Chronic Lymphocytic Leukemia

    Flow cytometry analyses revealed a higher eomesodermin (EOMES) expression in CD8+ T cells of chronic lymphocytic leukemia (CLL) patients compared to healthy individuals, and an accumulation of PD-1+ EOMES+ CD8+ T cells in lymph nodes rather than blood or bone marrow in CLL.
    [Leukemia]

    Full Article

    GPR15 Facilitates Recruitment of Regulatory T Cells to Promote Colorectal Cancer

    A dense infiltration of regulatory T cells in mouse and human colorectal cancer lesions correlated with increased expression of the orphan chemoattractant receptor GPR15 on these cells.
    [Cancer Research]

    Abstract

    IRF1 Governs the Differential Interferon-Stimulated Gene Responses in Human Monocytes and Macrophages by Regulating Chromatin Accessibility

    Monocytes were hyperresponsive to TLR7/8 stimulation that correlated with the higher expression of the receptors.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Itaconate Confers Tolerance to Late NLRP3 Inflammasome Activation

    Scientists demonstrated major inflammatory tolerance and cell death phenotypes associated with itaconate production in activated macrophages.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Patterns of Dendritic Cell and Monocyte Subsets Are Associated with Disease Severity and Mortality in Liver Cirrhosis Patients

    The authors investigated disturbances in circulating monocytes and dendritic cells in patients with acute decompensation of cirrhosis.
    [Scientific Reports]

    Full Article

    Fasting-Induced FOXO4 Blunts Human CD4+ T Helper Cell Responsiveness

    Investigators showed that fasting in humans was sufficient to blunt CD4+ T helper cell responsiveness.
    [Nature Metabolism]

    Abstract

    Guide to everything you need to know about cell separation.
    REVIEWS

    Targeting FAK in Anticancer Combination Therapies

    Scientists discuss the recent preclinical evidence that implicates FAK in anticancer therapeutic resistance, leading to the view that FAK inhibitors will have their greatest utility as combination therapies in selected patient populations.
    [Nature Reviews Cancer]

    Abstract

    Tissue-Specific Immunity for a Changing World

    The authors discuss how tissue immune responses are influenced by various stressors (e.g., metabolic, environmental, aging) that are rapidly changing due to climate fluctuations and globalization.
    [Cell]

    Abstract

    INDUSTRY AND POLICY NEWS

    AbbVie Announces Extension of Review for Supplemental New Drug Application of Upadacitinib for the Treatment of Adults with Active Psoriatic Arthritis

    AbbVie announced that the FDA has extended the review period for the supplemental New Drug Application for upadacitinib in the treatment of adult patients with active psoriatic arthritis.
    [AbbVie]

    Press Release

    FEATURED EVENT

    Innate Immunity: Mechanisms and Modulation

    April 12 – 15, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Faculty Position – Brain Immunology and Glia

    University of Virginia – Charlottesville, Virginia, United States

    Postdoctoral Fellow Position – B Cell Biology

    University of Toronto – Toronto, Ontario, Canada

    Research Fellow – RNA Biology

    Dana-Farber Cancer Institute – Boston, Massachusetts, United States

    Postdoc/Research Scientist – Immunology

    H. Lee Moffitt Cancer Center & Research Institute – Tampa, Florida, United States

    Postdoctoral Fellow – Human COVID Immunology

    Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States

    > See All Jobs

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