| Vol. 9.12 – 30 March, 2021 |
| |
|
|
| Researchers identified damaging monoallelic SYK variants in six patients with immune deficiency, multi-organ inflammatory disease such as colitis, arthritis and dermatitis, and diffuse large B cell lymphomas. [Nature Genetics] |
|
|
|
| PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| Scientists employed single-cell RNA sequencing and CITE-seq to map the glioblastoma immune landscape in mouse tumors and in patients with newly diagnosed disease or recurrence. [Nature Neuroscience] |
|
|
|
| The authors identified SLAMF5 for controlling IL-10+ regulatory B cell (Breg) maintenance and function. In EAE, the deficiency of SLAMF5 in B cells causes accumulation of IL10+ Bregs in the central nervous system and periphery. [Nature Communications] |
|
|
|
| Scientists showed that human lung and blood contains adaptive-like CD56brightCD16– NK cells with hallmarks of tissue residency, including expression of CD49a. [Proceedings of the National Academy of Sciences of the United States of America] |
|
|
|
| CCR8 was expressed by Tregs in both murine and human tumors, and unlike CCR4, a Treg depletion target in the clinic, CCR8 was selectively expressed on suppressive tumor Tregs and minimally expressed on proinflammatory effector T cells [Cancer Research] |
|
|
|
| Investigators showed that in humans, SLAMF6 has three splice isoforms involving its V-domain. Although the canonical receptor inhibited T-cell activation through SAP recruitment, the short isoform SLAMF6∆17-65 had a strong agonistic effect. [Cancer Immunology Research] |
|
|
|
| Scientists showed that adult T cell leukemia/lymphoma (ATL) could be detected early in HTLV-1-carriers through quantification of T-cell receptor (TCR)Vβ subunit diversity on T-cells infected with HTLV-1 using an ‘oligoclonality index’. [Blood Cancer Journal] |
|
|
|
| Researchers investigated the maturation of the CD8+ T cell compartment in human fetal, infant and adult intestinal tissues. CD8+ T cells exhibiting a memory phenotype were already detected in fetal intestines and increased after birth. [Mucosal Immunology] |
|
|
|
| A novel lncRNA was identified overexpressed in the main subtypes of peripheral T cell lymphoma, and designated as T cell lymphoma-associated lncRNA1. [Cell Death & Disease] |
|
|
|
| CARs containing a CD28-TMD, but not a CD8-TMD, formed heterodimers with the endogenous CD28 in human T cells, as shown by co-immunoprecipitation and CAR-dependent proliferation of anti-CD28 stimulation. [Frontiers in Immunology] |
|
|
|
| In a cohort of metastatic melanoma survivors with exceptional responses to immunotherapy, researchers probed memory CD8+ T-cell responses across tissues, and across several years. [Nature Cancer] |
|
|
|
|
| Scientists describe the key components of antibody-drug conjugate (ADC) structure and function and focus on the clinical development and subsequent utilization of two leukemia-directed ADCs. [Nature Reviews Clinical Oncology] |
|
|
|
| The authors summarize the role of macrophages in current immunotherapies and the advantages of targeting macrophages. [Signal Transduction and Targeted Therapy] |
|
|
|
|
| CARISMA Therapeutics Inc. announced that the first patient has been dosed in the Phase I multi-center clinical trial for CT-0508, a human epidermal growth factor receptor 2 targeted chimeric antigen receptor macrophage. [CARISMA Therapeutics Inc.] |
|
|
|
|
| April 21 – 23, 2021 Virtual |
|
|
|
|
|
| Swiss Federal Institute of Technology in Lausanne – Lausanne, Switzerland |
|
|
|
| University of Virginia – Charlottesville, Virginia, United States |
|
|
|
| University of Toronto – Toronto, Ontario, Canada |
|
|
|
| H. Lee Moffitt Cancer Center & Research Institute – Tampa, Florida, United States |
|
|
|
| Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
|
|
|
|