 | | Vol. 9.14 – 13 April, 2021 |
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| Researchers used positron emission tomography tracers to measure the access to and uptake of glucose and glutamine by specific cell subsets in the tumor microenvironment. Notably, myeloid cells had the greatest capacity to take up intratumoral glucose, followed by T cells and cancer cells, across a range of cancer models.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists identified the nuclear xenobiotic receptor CAR as a regulator of MDR1 expression in T cells that could safeguard against bile acid toxicity and inflammation in the mouse small intestine.
[Nature] |
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| CD4+ T cells in patients with IPEX syndrome and Foxp3-deficient mice were analyzed by single-cell cytometry and RNA-sequencing, revealing heterogeneous Treg-like cells, some very similar to normal Treg cells, others more distant.
[Nature Immunology] |
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| The authors showed that HIV could penetrate the epithelial surface to interact with sub-epithelial resident mononuclear phagocytes in anogenital explants and defined the full array of subsets that were present in the human anogenital and colorectal tissues that HIV may encounter during sexual transmission.
[Nature Communications] |
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| Researchers combined single-cell RNA-sequencing and antigen receptor lineage analysis to characterize a large number of triple-negative breast cancer infiltrated immune cells and report a comprehensive atlas of tumor-infiltrated B-lymphocytes.
[Nature Communications] |
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| In syngeneic mouse colorectal cancer (CRC) models and human patient-derived CRC organoid models, atractylenolide I treatment promoted the cytotoxicity of CD8+ T cells and thus profoundly enhanced the efficacy of immune checkpoint blockade therapy.
[Journal of Clinical Investigation] |
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| Researchers describe a detailed protocol for the purification and ex vivo expansion of primary, nonmalignant human germinal center B cells.
[Nature Protocols] |
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| Using an original ex vivo model of B-cell receptor-induced proliferation of chronic lymphocytic leukemia cells, investigators generated 108 temporal transcriptional and proteomic profiles from one hour up to four days after BCR activation.
[Leukemia] |
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| The authors investigated the effects of glioma-derived exosomes on autophagy, the polarization of tumor-associated macrophages, and glioma progression.
[Cell Death & Disease] |
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| Scientists outline the principal elements of the cGAS–STING signaling cascade and discuss the general mechanisms underlying the association of cGAS–STING activity with various autoinflammatory, autoimmune and degenerative diseases.
[Nature Reviews Immunology] |
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| The authors discuss a paradigm shift by suggesting that beyond these reactions, chronic inflammation is driven by imprinted, pathogenic ‘memory’ cells of the immune system.
[Nature Reviews Rheumatology] |
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| Three CAR-T cell products are currently approved by the FDA, with others in clinical trials. Additional agents in development include bispecific antibodies and antibody drug conjugates.
[Blood Cancer Journal] |
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| City of Hope and CytoImmune Therapeutics Inc. have entered into worldwide exclusive license agreements to several patent applications related to methods to generate large numbers of fully functional natural killer (NK) cells derived from umbilical cord blood and compositions of chimeric receptors (CAR) for targeting NK cells to tumors.
[CytoImmune Therapeutics, Inc. (BusinessWire, Inc)] |
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| May 10 – 15, 2021
Virtual |
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| | University of Pennsylvania – Philadelphia, Pennsylvania, United States |
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| | University of California Irvine – Irvine, California, United States |
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| | Swiss Federal Institute of Technology in Lausanne – Lausanne, Switzerland |
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| | University of Virginia – Charlottesville, Virginia, United States |
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| | University of Toronto – Toronto, Ontario, Canada |
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