 | | Vol. 9.15 – 20 April, 2021 |
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| Using cancer patient samples and proteomics, scientists found that human NK cell dysfunction in the tumor microenvironment was due to suppression of glucose metabolism via lipid peroxidation-associated oxidative stress.
[Cell Metabolism] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators used nonintegrating minimally sized DNA vectors with an enhanced capability of generating genetically modified cells, and they demonstrated that they could be efficiently used to engineer human T lymphocytes.
[Science Advances] |
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| The authors showed that variants associated with differential PU.1 binding underlied genetically-driven differences in cell count and susceptibility to autoimmune and inflammatory diseases.
[Nature Communications] |
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| Scientists report that long-term stress surprisingly abrogates both T helper 1 (TH1)- and TH2-type responses orchestrated by invariant natural killer T cells.
[Cell Reports] |
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| Investigators characterized the role of T cell immunoglobulin and mucin domain containing 3 (TIM-3) in restimulation-induced cell death regulation.
[Cell Death & Disease] |
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| Researchers identified dimethylarginine dimethylaminohydrolase 2 (DDAH2) as a potent regulator of the RIG-I–like receptor-mediated antiviral response in human and mouse.
[Science Signaling] |
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| Scientists investigated the downstream signaling pathways by which IgD activated T cells as well as the possible role of IgD in the T–B interaction.
[Acta Pharmacologica Sinica] |
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| Investigators present a GMP-compatible mRNA electroporation protocol for the automated production of CCR5-edited CD4+-T cells in the closed CliniMACS Prodigy system.
[Gene Therapy] |
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| To better understand the mechanistic effect cromolyn has in slowing down or halting the neuroinflammatory response associated with Alzheimer’s disease progression, the authors tested the effect of cromolyn to dampen the inflammatory response in the human HMC3 microglia cell line.
[Scientific Reports] |
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| Investigators review the current understanding of the pathobiology, clinical manifestations and treatment approaches to endocrine toxicities arising from immune checkpoint inhibitors.
[Nature Reviews Endocrinology] |
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| The authors explore how advances in the study of human immunology have shaped the understanding of the resident immune network and its response to two of the most commonly encountered inflammatory stimuli in the airways: viruses and allergens.
[Immunity] |
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| Scientists present both sides of the story with a particular emphasis on the beneficial properties of innate immune cells and how they can be targeted to have neuroprotective properties.
[Molecular Psychiatry] |
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| VBI Vaccines, Inc. announced data and next steps from the high-dose cohort of its Phase Ib/IIa clinical study of VBI-2601 (BRII-179), the company’s hepatitis B immunotherapeutic candidate, in chronically-infected hepatitis B patients.
[VBI Vaccines, Inc. (Business Wire, Inc.)] |
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| May 17 – 21, 2021
Virtual |
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| | Boston Children’s Hospital – Boston, Massachusetts, United States |
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| | University of Pennsylvania – Philadelphia, Pennsylvania, United States |
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| | University of California Irvine – Irvine, California, United States |
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| | Swiss Federal Institute of Technology in Lausanne – Lausanne, Switzerland |
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| | University of Virginia – Charlottesville, Virginia, United States |
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