Human Immunology News Volume 9.16 | Apr 27 2021

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    HIN 9.16 | Apr 27 2021


    Human Immunology News by STEMCELL Technologies
    Vol. 9.16 – 27 April, 2021
    TOP STORY

    Gasdermin D Pore Structure Reveals Preferential Release of Mature Interleukin-1

    Investigators report cryo-electron microscopy structures of the pore and the prepore of gasdermin D.
    [Nature]

    Abstract

    Microscopy images of pluripotent stem cells (PSCs) and PSC-derived cells for the #StemCellfie contest.
    PUBLICATIONSRanked by the impact factor of the journal

    The CD94/NKG2A Inhibitory Receptor Educates Uterine NK Cells to Optimize Pregnancy Outcomes in Humans and Mice

    Researchers showed that NKG2A genetic ablation in dams mated with wild-type males caused suboptimal maternal vascular responses in pregnancy, accompanied by perturbed placental gene expression, reduced fetal weight, greater rates of smaller fetuses with asymmetric growth, and abnormal brain development.
    [Immunity]

    AbstractGraphical Abstract

    Perivascular Macrophages Regulate Blood Flow Following Tissue Damage

    Using intravital microscopy of ischemic hind limb muscle in mice, and confocal microscopy of human tissues from amputated legs, scientists found that macrophages accumulated perivascularly in ischemic muscles, where they expressed high levels of iNOS.
    [Circulation Research]

    Abstract

    Natural Killer Cell Receptors Regulate Responses of HLA-E–Restricted T Cells

    Researchers showed that the UL40/HLA-E T cell receptor (TCR) repertoire included TCRs that had high affinities for HLA-E/self-peptide.
    [Science Immunology]

    Abstract

    Disruption of the HER3-PI3K-mTOR Oncogenic Signaling Axis and PD-1 Blockade as a Multimodal Precision Immunotherapy in Head and Neck Cancer

    The authors employed an unbiased kinome-wide siRNA screen to reveal that HER3, was essential for the proliferation of most head and neck squamous cell carcinoma cells that did not harbor PIK3CA mutations.
    [Nature Communications]

    Full Article

    CRISPR-Cas9 Cytidine and Adenosine Base Editing of Splice-Sites Mediates Highly-Efficient Disruption of Proteins in Primary and Immortalized Cells

    Investigators developed SpliceR to design and rank BE-splice sgRNAs for any Ensembl annotated genome, and compared disruption approaches in T cells using a screen against the TCR-CD3 MHC Class I immune synapse.
    [Nature Communications]

    Full Article

    Human KIT+ Myeloid Cells Facilitate Visceral Metastasis by Melanoma

    Using humanized mice that colonization of distant visceral organs with melanoma was dependent upon a human CD33+CD11b+CD117+ progenitor cell subset comprising.
    [Journal of Experimental Medicine]

    Full Article

    CCL2 Regulation of MST1-mTOR-STAT1 Signaling Axis Controls BCR Signaling and B-Cell Differentiation

    In SLE patients, decreased expression of CCL2 on mesenchymal stem cells prevented inhibition of B-cell proliferation, causing the characteristic autoimmune phenotype.
    [Cell Death & Differentiation]

    Abstract

    Serum Levels of Soluble B and T Lymphocyte Attenuator (sBTLA) Predict Overall Survival in Patients Undergoing Immune Checkpoint Inhibitor Therapy for Solid Malignancies

    Researchers evaluated circulating levels of the soluble form of BTLA, sBTLA, as a biomarker for the prediction of treatment response and outcome to immune checkpoint inhibitor therapy.
    [International Journal of Cancer]

    Abstract

    Transcriptomic Analysis of Immune Cells in a Multi-Ethnic Cohort of Systemic Lupus Erythematosus Patients Identifies Ethnicity- and Disease-Specific Expression Signatures

    Scientists leveraged cell-sorted RNA-seq data from 120 systemic lupus erythematosus patients and applied a four-tier approach including unsupervised clustering, differential expression analyses, gene co-expression analyses.
    [Communications Biology]

    Full Article

    Regulatory T Cells Induce Polarization of Pro-repair Macrophages by Secreting sFGL2 into the Endometriotic Milieu

    Researchers showed that the level of Tregs-derived soluble fibrinogen-like protein 2 increased in the peritoneal fluid of women with endometriosis.
    [Communications Biology]

    Full Article

    The BET Inhibitor Attenuates the Inflammatory Response and Cell Migration in Human Microglial HMC3 Cell Line

    The authors investigated the mechanisms underlying the anti-inflammatory and anti-migratory functions of JQ1 and the genes targeted by JQ1 in lipopolysaccharide-activated human microglial clone 3 cells using RNA-sequencing.
    [Scientific Reports]

    Full Article

    View tips on how to organize your lab bench space.
    REVIEWS

    The Changing Landscape of Atherosclerosis

    Inflammatory pathways and leukocytes link traditional and emerging risk factors alike to the altered behaviour of arterial wall cells.
    [Nature]

    Abstract

    INDUSTRY AND POLICY NEWS

    D&D Pharmatech Announces Sponsored Research Agreement with Yale University to Optimize Novel Strategies for the Treatment of Brain Cancer and Other Diseases of the Central Nervous System

    D&D Pharmatech, Inc. announced it has entered into a sponsored research agreement with Yale University relating to optimization of two novel approaches that allow immune system cells and drug molecules to bypass the blood-brain barrier for the treatment of brain cancer and other disorders.
    [D&D Pharmatech, Inc. (Business Wire, Inc.))]

    Press Release

    FEATURED EVENT

    3rd Treg Directed Therapies Summit

    May 18 – 20, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Skin Immunology

    Baltimore, United States

    Technical Assistant – Mucosal Immunology

    Research Center for Molecular Medicine – Vienna, Austria

    Postdoctoral Research Fellow – Precision Vaccine Program

    Boston Children’s Hospital – Boston, Massachusetts, United States

    Postdoctoral Position – T Follicular Helper Cell Differentiation

    University of Pennsylvania – Philadelphia, Pennsylvania, United States

    Postdoc – Translational Human Immunology

    University of California Irvine – Irvine, California, United States

    > See All Jobs

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