Human Immunology News Volume 9.17 | May 4 2021

May 12, 2022

2021-05-04 | HIN 9.17

Human Immunology News by STEMCELL Technologies

Vol. 9.17 – 4 May, 2021

TOP STORY

Dynamic
Landscape of Immune Cell-Specific Gene Regulation in Immune-Mediated Diseases

Investigators performed a large-scale immune cell gene-expression analysis, together with whole-genome sequence analysis of a dataset consisting of 28 distinct immune cell subsets from 337 patients diagnosed with ten categories of immune-mediated diseases and 79 healthy volunteers.
[Cell]

Abstract Press Release
Graphical Abstract

PUBLICATIONSRanked by the impact factor of the journal

Cancer
Cells Retrace a Stepwise Differentiation Program during Malignant Progression

Using multi-omics approaches, researchers revealed that metastasis-like primary tumors arise from islet tumors via dedifferentiation following a reverse trajectory along the developmental pathway of islet B cells, which results in the acquisition of a progenitor-like molecular phenotype.
[Cancer Discovery]

Abstract

CD276
Expression Enables Squamous Cell Carcinoma Stem Cells to Evade Immune Surveillance

The authors showed that cancer stem cells upregulated the immune checkpoint molecule CD276 to evade host immune responses.
[Cell Stem Cell]

Abstract Press Release
Graphical Abstract

Identification of TAPBPL as a Novel Negative Regulator of T-Cell Function

A soluble recombinant human TAPBPL‐IgG Fc fusion protein inhibited the proliferation, activation, and cytokine production of both mouse and human T cells in vitro.
[EMBO Molecular Medicine]

Full Article

Pooled
Analysis of Safety Data from Clinical Trials Evaluating Acalabrutinib Monotherapy in Mature B-Cell Malignancies

To characterize acalabrutinib tolerability, scientists pooled safety data from 1040 patients with mature B-cell malignancies treated with acalabrutinib monotherapy in nine clinical studies.
[Leukemia]

Abstract

PD-L1 Signaling on Human Memory CD4⁺
T Cells Induces a Regulatory Phenotype

Researchers demonstrated that programmed death cell receptor 1 (PD-1) ligation on human CD25-depleted CD4⁺ T cells, combined with CD3/T cell receptor stimulation, induced their conversion into highly suppressive T cells.
[PLOS Biology]

Full Article

Select Hyperactivating NLRP3 Ligands Enhance the T_H1- and T_H
17-Inducing Potential of Human Type 2 Conventional Dendritic Cells

Investigators found that the conventional type 2 dendritic cell (DC) subset was the major human DC subset that was transcriptionally and functionally poised for inflammasome formation and response without pyroptosis.
[Science Signaling]

Full Article

CRISPR-Edited
CART with GM-CSF Knockout and Auto Secretion of IL6 and IL1 Blockers in Patients with Hematologic Malignancy

To minimize GM-CSF production from CART to reduce its associated toxicity, scientists conducted a pilot study of CRISPR-edited GM-CSF knockout (KO) in CART secreting anti-IL6 scFv and IL1RA, with additional TCR KO for tracing edited CART.
[Cell Discovery]

Full Article

Predictive
Value of Tyrosine Phosphatase Receptor Gamma for the Response to Treatment Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia Patients

Researchers employed flow cytometry to monitor the changes in the expression level of protein tyrosine phosphatase receptor gamma in the white blood cells of chronic myeloid leukemia patients at the time of diagnosis and following treatment with tyrosine kinase inhibitors.
[Scientific Reports]

Full Article

Suppression of Human T Cell Activation by Derivatives of Glycerol Monolaurate

Investigators performed an extensive structure activity relationship analysis to investigate the structural components of glycerol monolaurate necessary for its suppression of human T cell activation.
[Scientific Reports]

Full Article

Generation
of Cryopreserved Macrophages from Normal and Genetically Engineered Human Pluripotent Stem Cells for Disease Modelling

The authors describe the step wise generation and characterization of macrophages from induced pluripotent stem cells using a defined serum free method amenable to scale up to generate a large batch of pure end stage cryopreservable macrophages.
[PLOS ONE]

Full Article

Explore scientific events this May with the Science Events Calendar.

REVIEWS

Metabolic Barriers to Cancer Immunotherapy

Investigators discuss the metabolic aspects of the antitumor T cell response in the context of immune checkpoint blockade, adoptive cell therapy and treatment with oncolytic viruses, and discuss emerging combination strategies.
[Nature Reviews Immunology]

Abstract

Interferon Lambda in Inflammation and Autoimmune Rheumatic Diseases

The authors provide a critical evaluation of the current literature on type III interferons biology and how IFNλs might contribute to immune dysregulation and tissue damage in autoimmunity.
[Nature Reviews Rheumatology]

Full Article

Interfaces
between Cellular Responses to DNA Damage and Cancer Immunotherapy

Scientists review the current understanding of the molecular mechanisms underlying DNA damage-triggered immune responses, including cytosolic DNA sensing via the cGAS/STING pathway.
[Genes & Development]

Abstract

INDUSTRY AND POLICY NEWS

Exelixis
Expands its Biotherapeutics Portfolio with Acquisition of GamaMabs Pharma’s First-in-Class Humanized Antibody Program against a Novel Oncology Target

Exelixis, Inc. and GamaMabs Pharma SA announced that they have entered into an agreement under which Exelixis will, upon the future closing of the asset purchase and subject to certain conditions to closing, acquire all rights, title and interest in GamaMabs’ AMHR2 antibody technology.
[Exelixis, Inc.]

Press Release

Genprex Initiates Site Recruitment for Acclaim-2 Clinical Trial for the Treatment of Non-Small Cell Lung Cancer

Genprex, Inc. announced it has commenced clinical trial site recruitment for its upcoming Acclaim-2 clinical trial for the treatment of non-small cell lung cancer.
[Genprex, Inc. (BusinessWire, Inc.)]

Press Release

FEATURED EVENT

Dynamic
Landscape of Immune Cell-Specific Gene Regulation in Immune-Mediated Diseases

Cancer
Cells Retrace a Stepwise Differentiation Program during Malignant Progression

CD276
Expression Enables Squamous Cell Carcinoma Stem Cells to Evade Immune Surveillance

Identification of TAPBPL as a Novel Negative Regulator of T-Cell Function

Pooled
Analysis of Safety Data from Clinical Trials Evaluating Acalabrutinib Monotherapy in Mature B-Cell Malignancies

PD-L1 Signaling on Human Memory CD4⁺
T Cells Induces a Regulatory Phenotype

Select Hyperactivating NLRP3 Ligands Enhance the T_H1- and T_H
17-Inducing Potential of Human Type 2 Conventional Dendritic Cells

CRISPR-Edited
CART with GM-CSF Knockout and Auto Secretion of IL6 and IL1 Blockers in Patients with Hematologic Malignancy

Predictive
Value of Tyrosine Phosphatase Receptor Gamma for the Response to Treatment Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia Patients

Suppression of Human T Cell Activation by Derivatives of Glycerol Monolaurate

Generation
of Cryopreserved Macrophages from Normal and Genetically Engineered Human Pluripotent Stem Cells for Disease Modelling

Metabolic Barriers to Cancer Immunotherapy

Interferon Lambda in Inflammation and Autoimmune Rheumatic Diseases

Interfaces
between Cellular Responses to DNA Damage and Cancer Immunotherapy

Exelixis
Expands its Biotherapeutics Portfolio with Acquisition of GamaMabs Pharma’s First-in-Class Humanized Antibody Program against a Novel Oncology Target

Genprex Initiates Site Recruitment for Acclaim-2 Clinical Trial for the Treatment of Non-Small Cell Lung Cancer

STING & TLR-Targeting Therapies Digital Summit

>
See All Events

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