Human Immunology News Volume 9.19 | May 18 2021

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    2021-05-18 | HIN 9.19


    Human Immunology News by STEMCELL Technologies
    Vol. 9.19 – 18 May, 2021
    TOP STORY

    PKM2-Dependent Metabolic Skewing of Hepatic Th17 Cells Regulates Pathogenesis of Non-Alcoholic Fatty Liver Disease

    Scientists uncovered and characterized a distinct population of inflammatory hepatic CXCR3+Th17 cells sufficient to exacerbate non-alcoholic fatty liver disease pathogenesis.
    [Cell Metabolism]

    AbstractGraphical Abstract

    Bruno Silva-Santos shares his work on understanding the role of gamma delta T cells in cancer immunity. Watch the webinar.
    PUBLICATIONSRanked by the impact factor of the journal

    Targeting Human Acyl-CoA:cholesterol Acyltransferase as a Dual Viral and T Cell Metabolic Checkpoint

    Acyl-CoA:cholesterol acyltransferase inhibition reduced CD8+ T cell neutral lipid droplets and promoted lipid microdomains, enhancing TCR signalling and TCR-independent bioenergetics.
    [Nature Communications]

    Abstract

    Longitudinal Single-Cell Profiling Reveals Molecular Heterogeneity and Tumor-Immune Evolution in Refractory Mantle Cell Lymphoma

    The authors characterized the cellular and molecular heterogeneity within and across patients and delineated the dynamic evolution of tumor and immune cell compartments at single cell resolution in longitudinal specimens from ibrutinib-sensitive patients and non-responders.
    [Nature Communications]

    Full Article

    Targeting Cholesterol Biosynthesis Promotes Anti-Tumor Immunity by Inhibiting Long Noncoding RNA SNHG29 Mediated YAP Activation

    Researchers found that simvastatin inhibited PD-L1 expression and promoted anti-tumor immunity via suppressing the expression of long non-coding RNA SNHG29.
    [Molecular Therapy]

    Abstract

    Liver Fibrosis Promotes Immune Escape in Hepatocellular Carcinoma via GOLM1-Mediated PD-L1 Upregulation

    In hepatocellular carcinoma patients, low FIB-4 values and high CD8+ T cell infiltration were correlated with prolonged survival.
    [Cancer Letters]

    Abstract

    Bispecific Antibody Simultaneously Targeting PD1 and HER2 Inhibits Tumor Growth via Direct Tumor Cell Killing in Combination with PD1/PDL1 Blockade and HER2 Inhibition

    Scientists developed a bispecific antibody simultaneously targeting both PD1 and HER2 in an attempt to combine HER2-targeted therapy with immune checkpoint blockade for treating HER2-positive solid tumors.
    [Acta Pharmacologica Sinica]

    Full Article

    Induction of the Apoptosis, Degranulation and IL-13 Production of Human Basophils by Butyrate and Propionate via Suppression of Histone Deacetylation

    Investigators elucidated the function of short chain fatty acids on human basophils. Human basophils were purified from healthy donors by flow cytometric sorting.
    [British Journal of Immunology]

    Abstract

    Correlating Immune Cell Infiltration Patterns with Recurrent Somatic Mutations in Advanced Clear Cell Renal Cell Carcinoma

    Researchers analyzed the associations between common clear cell renal cell carcinoma somatic mutations and immune cell infiltration patterns within the tumor immune microenvironment
    [European Urology Focus]

    Abstract

    Generation of an Isoform-Level Transcriptome Atlas of Macrophage Activation

    Using the long-read nanopore-based R2C2 method, which did not fragment RNA molecules, investigators generated an Isoform-level transcriptome Atlas of Macrophage Activation that identified full-length isoforms in primary human monocyte-derived macrophages.
    [Journal of Biological Chemistry]

    Full Article
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    REVIEWS

    Interleukin-6 Signaling and Anti-Interleukin-6 Therapeutics in Cardiovascular Disease

    Scientists provide an overview of the mechanisms by which IL-6 signaling occurs and how that impacts upon pharmacologic inhibition, and describe murine models of IL-6 and atherogenesis.
    [Circulation Research]

    Abstract

    Ferroptosis in Infection, Inflammation, and Immunity

    The authors discuss new discoveries related to how ferroptotic cells and their spilled contents shape innate and adaptive immunity in health and disease.
    [Journal of Experimental Medicine]

    Abstract

    Current Strategies in Engaging Oncolytic Viruses with Antitumor Immunity

    Investigators review recent efforts on arming oncolytic viruses with a variety of immune stimulator molecules, immune cell engagers, and other immune potentiating molecules.
    [Molecular Therapy-Oncolytics]

    AbstractGraphical Abstract
    INDUSTRY AND POLICY NEWS

    Agenus and Bristol Myers Squibb Announce Exclusive Global License for Agenus’ Anti-TIGIT Bispecific Antibody Program

    Bristol-Myers Squibb Company and Agenus, Inc.announced that they have entered into a definitive agreement under which Bristol Myers Squibb will be granted a global exclusive license to Agenus’ proprietary bispecific antibody program, AGEN1777, that blocks TIGIT and a second undisclosed target.
    [Bristol-Myers Squibb]

    Press Release

    Imugene Licenses Cd19 Oncolytic Virus from City of Hope to Turn CAR T Therapy Against Solid Tumors

    Imugene Ltd announced they have entered into a licensing agreement for the patents covering a novel combination immunotherapy. The therapy unleashes a CD19-expressing oncolytic virus to enable CD19-directed chimeric antigen receptor (CAR) T cell therapies to target solid rumors, which are currently otherwise difficult to treat with CAR T cell therapy alone.
    [Imugene Ltd (BusinessWire, Inc.)]

    Press Release
    FEATURED EVENT

    Myeloid Cells: From Development to Function and Dysfunction

    June 4, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Researcher – Host-Microbiome Interactions

    Kings’s College London – London, England, United Kingdom

    Research Technician – Molecular Immunology

    Universit̩ Libre de Bruxelles РBrussels, Belgium

    Research Fellow – Vaccine Adjuvants for Cancer and Viruses

    Trinity College Dublin – Dublin, Republic of Ireland

    Research Technician – Molecular Immunology

    Universit̩ Libre de Bruxelles РBrussels, Belgium

    Postdoctoral Fellow – Cancer Immunology and Immunotherapy

    Columbia University Medical Center – New York City, New York, United States

    > See All Jobs

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