|
| Scientists performed single-cell RNA sequencing of hematopoietic and non-hematopoietic subpopulations from tumor and tumor-adjacent tissue of treatment-naive clear cell renal carcinoma resections. [Cell] |
| |
|
|
PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| Integrative epigenomic analysis revealed widespread histone H3 amino terminus proteolytic cleavage distribution across the genome in a monocytic cell line and primary monocytes, which became largely undetectable in fully differentiated macrophages. [Nature Immunology] |
|
|
|
| The authors showed that induction of noncanonical NF-κB signaling induces T cell–dependent immune responses, even in β2-microglobulin–deficient tumors, demonstrating that direct CD8 T cell recognition of tumor cell–expressed major histocompatibility complex class I was not required. [Science Translational Medicine] |
|
|
|
| Investigators engineered poly(ethylene glycol) (PEG) particles using a mesoporous silica templating method and investigated how the PEG building block architecture impacted the physicochemical properties of the PEG particles and subsequently modulated particle–immune cell interactions in human blood. [ACS Nano] |
|
|
|
| Scientists developed the selective anti-Transthyretin amyloid antibody NI301A, a recombinant human monoclonal immunoglobulin G1. [Nature Communications] |
|
|
|
| The authors combined new and previously published single-cell RNA-seq data from 98,015 single cells from a total of 66 gliomas to profile 19,331 individual macrophages. [Genome Medicine] |
|
|
|
| Scientists investigated sex-based differences in the molecular mechanisms of anticancer immune-response and immune evasion in patients with non-small cell lung cancer. [Clinical Cancer Research] |
|
|
|
| Researchers explored the role of liver X receptor (LXR)-regulated metabolic processes in primary human CD4+ T cells and their role in controlling plasma membrane lipids, which strongly influenced T cell immune signaling and function. [Proceedings of the National Academy of Sciences of the United States of America] |
|
|
|
| Patients with high-risk ductal carcinoma in situ were enrolled in this 3×3 Phase I dose-escalation pilot study of two, four and eight mg intralesional injections of the PD-1 immune checkpoint inhibitor, pembrolizumab. [npj Breast Cancer] |
|
|
|
| Investigators integrated deleterious somatic and germline mutations and methylation data of DDR genes in 10,080 cancers representing 32 cancer types and evaluated the associations of these alterations with tumor neoantigens and immune infiltrates. [Cell Reports Medicine] |
|
|
|
|
| The authors propose that understanding the immune consequences of targeting nucleotide metabolism against cancers may be harnessed to optimize therapy against viral infections. [Science Advances] |
|
|
|
|
| GammaDelta Therapeutics has received Investigational New Drug approval from the FDA for the company’s allogeneic variable delta 1 gamma-delta T cell therapy, GDX012, to be investigated as a treatment for blood cancers. [The Francis Crick Institute] |
|
|
|
| Genmab A/S announced that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency has adopted a positive opinion and recommended granting marketing authorization for the daratumumab SC formulation, known as DARZALEX® SC in the European Union, in combination with bortezomib, cyclophosphamide, and dexamethasonefor the treatment of adult patients with newly diagnosed systemic light-chain amyloidosis. [Genmab A/S] |
|
|
|
|
|
|
|
| Icahn School of Medicine at Mount Sinai – New York City, New York, United States |
|
|
|
| Medical College of Wisconsin – Milwaukee, Wisconsin, United States |
|
|
|
| Kings’s College London – London, England, United Kingdom |
|
|
|
| Trinity College Dublin – Dublin, Ireland |
|
|
|
| Columbia University Medical Center – New York City, New York, United States |
|
|
|
|