Human Immunology News Volume 9.20 | May 25 2021

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    2021-05-25 | HIN 9.20


    Human Immunology News by STEMCELL Technologies
    Vol. 9.20 – 25 May, 2021
    TOP STORY

    Single-Cell Protein Activity Analysis Identifies Recurrence-Associated Renal Tumor Macrophages

    Scientists performed single-cell RNA sequencing of hematopoietic and non-hematopoietic subpopulations from tumor and tumor-adjacent tissue of treatment-naive clear cell renal carcinoma resections.
    [Cell]

    AbstractPress ReleaseGraphical Abstract
    Webinar: Organoids as Models for Human Disease
    PUBLICATIONSRanked by the impact factor of the journal

    Repression of CTSG, ELANE and PRTN3-Mediated Histone H3 Proteolytic Cleavage Promotes Monocyte-to-Macrophage Differentiation

    Integrative epigenomic analysis revealed widespread histone H3 amino terminus proteolytic cleavage distribution across the genome in a monocytic cell line and primary monocytes, which became largely undetectable in fully differentiated macrophages.
    [Nature Immunology]

    Abstract

    cIAP1/2 Antagonism Eliminates MHC Class I–Negative Tumors through T Cell–Dependent Reprogramming of Mononuclear Phagocytes

    The authors showed that induction of noncanonical NF-κB signaling induces T cell–dependent immune responses, even in β2-microglobulin–deficient tumors, demonstrating that direct CD8 T cell recognition of tumor cell–expressed major histocompatibility complex class I was not required.
    [Science Translational Medicine]

    Abstract

    Influence of Poly(ethylene glycol) Molecular Architecture on Particle Assembly and Ex Vivo Particle–Immune Cell Interactions in Human Blood

    Investigators engineered poly(ethylene glycol) (PEG) particles using a mesoporous silica templating method and investigated how the PEG building block architecture impacted the physicochemical properties of the PEG particles and subsequently modulated particle–immune cell interactions in human blood.
    [ACS Nano]

    AbstractGraphical Abstract

    A Human Antibody Selective for Transthyretin Amyloid Removes Cardiac Amyloid through Phagocytic Immune Cells

    Scientists developed the selective anti-Transthyretin amyloid antibody NI301A, a recombinant human monoclonal immunoglobulin G1.
    [Nature Communications]

    Full Article

    Single-Cell Characterization of Macrophages in Glioblastoma Reveals MARCO as a Mesenchymal Pro-Tumor Marker

    The authors combined new and previously published single-cell RNA-seq data from 98,015 single cells from a total of 66 gliomas to profile 19,331 individual macrophages.
    [Genome Medicine]

    Full Article

    Sex-Based Dimorphism of Anticancer Immune Response and Molecular Mechanisms of Immune Evasion

    Scientists investigated sex-based differences in the molecular mechanisms of anticancer immune-response and immune evasion in patients with non-small cell lung cancer.
    [Clinical Cancer Research]

    Abstract

    LXR Directly Regulates Glycosphingolipid Synthesis and Affects Human CD4+ T Cell Function

    Researchers explored the role of liver X receptor (LXR)-regulated metabolic processes in primary human CD4+ T cells and their role in controlling plasma membrane lipids, which strongly influenced T cell immune signaling and function.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    Modulation of the Immune Microenvironment of High-Risk Ductal Carcinoma In Situ by Intralesional Pembrolizumab Injection

    Patients with high-risk ductal carcinoma in situ were enrolled in this 3×3 Phase I dose-escalation pilot study of two, four and eight mg intralesional injections of the PD-1 immune checkpoint inhibitor, pembrolizumab.
    [npj Breast Cancer]

    Full Article

    Diverse Immune Response of DNA Damage Repair-Deficient Tumors

    Investigators integrated deleterious somatic and germline mutations and methylation data of DDR genes in 10,080 cancers representing 32 cancer types and evaluated the associations of these alterations with tumor neoantigens and immune infiltrates.
    [Cell Reports Medicine]

    AbstractGraphical Abstract
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    REVIEWS

    Targeting Nucleotide Metabolism as the Nexus of Viral Infections, Cancer, and the Immune Response

    The authors propose that understanding the immune consequences of targeting nucleotide metabolism against cancers may be harnessed to optimize therapy against viral infections.
    [Science Advances]

    Full Article
    INDUSTRY AND POLICY NEWS

    Crick Spinout to Begin First-in-Human Clinical Study for Leukemia

    GammaDelta Therapeutics has received Investigational New Drug approval from the FDA for the company’s allogeneic variable delta 1 gamma-delta T cell therapy, GDX012, to be investigated as a treatment for blood cancers.
    [The Francis Crick Institute]

    Press Release

    Genmab Announces that Janssen Has Received Positive CHMP Opinion Recommending DARZALEX® (Daratumumab) Subcutaneous (SC) Formulation for Patients with Newly Diagnosed Light-Chain (AL) Amyloidosis

    Genmab A/S announced that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency has adopted a positive opinion and recommended granting marketing authorization for the daratumumab SC formulation, known as DARZALEX® SC in the European Union, in combination with bortezomib, cyclophosphamide, and dexamethasonefor the treatment of adult patients with newly diagnosed systemic light-chain amyloidosis.
    [Genmab A/S]

    Press Release
    FEATURED EVENT

    Natural Killer Cell Symposium 2021

    June 14 -16, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Assistant Professor – Human Innate Immunology

    Icahn School of Medicine at Mount Sinai – New York City, New York, United States

    Faculty Positions – Immuno-Oncology

    Medical College of Wisconsin – Milwaukee, Wisconsin, United States

    Postdoctoral Researcher – Host-Microbiome Interactions

    Kings’s College London – London, England, United Kingdom

    Research Fellow – Vaccine Adjuvants for Cancer and Viruses

    Trinity College Dublin – Dublin, Ireland

    Postdoctoral Fellow – Cancer Immunology and Immunotherapy

    Columbia University Medical Center – New York City, New York, United States

    > See All Jobs

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