Human Immunology News Volume 9.21 | June 1 2021

May 12, 2022

2021-06-01 | HIN 9.21

Human Immunology News by STEMCELL Technologies

Vol. 9.21 – 1 June, 2021

TOP STORY

Microbial Exposure during Early Human Development Primes Fetal Immune Cells

Researchers profiled microbes across fetal organs using 16S rRNA gene sequencing and detected low but consistent microbial signal in fetal gut, skin, placenta, and lungs in the 2nd trimester of gestation.
[Cell]

Full Article Graphical Abstract

Explore scientific events this June with the Science Events Calendar.

PUBLICATIONSRanked by the impact factor of the journal

Single-Cell Transcriptome Analysis Identifies Skin-Specific T-Cell Responses in Systemic Sclerosis

Single-cell RNA sequencing was performed by droplet-based sequencing, focusing on 3729 CD3⁺ lymphocytes from skin biopsies of 27 patients with active systemic sclerosis and 10 healthy donors.
[Annals of the Rheumatic Diseases]

Abstract

Impact of Rare and Common Genetic Variation in the Interleukin-1 Pathway on Human Cytokine Responses

Scientists performed molecular inversion probe sequencing on 48 IL-1 pathway-related genes in 463 healthy individuals from the Human Functional Genomics Project.
[Genome Medicine]

Full Article

Single Cell Characterization of the Immune Microenvironment of Melanoma Brain and Leptomeningeal Metastases

Researchers used single cell RNA-Seq to define the immune landscape of MBM, LMM and melanoma skin metastases. Single cell RNA-sequencing was undertaken on 43 patient specimens.
[Clinical Cancer Research]

Abstract

Dysregulated Immunity in PID Patients with Low GARP Expression on Tregs Due to Mutations in LRRC32

Investigators performed whole-exome sequencing of patients with immune dysregulation disorders and identified two patients with previously undescribed mutations in LRRC32, which encoded glycoprotein A repetitions predominant.
[Cellular & Molecular Immunology]

Full Article

Pro-Resolving Lipid Mediator Lipoxin A4 Attenuates Neuro-Inflammation by Modulating T Cell Responses and Modifies the Spinal Cord Lipidome

Scientists provided in vivo evidence that treatment with the SPM lipoxin A4 ameliorates clinical symptoms of experimental autoimmune encephalomyelitis and inhibited CD4⁺ and CD8⁺ T cell infiltration into the central nervous system.
[Cell Reports]

Full Article

Targeted Delivery of CRISPR-Cas9 and Transgenes Enables Complex Immune Cell Engineering

The authors developed a one-step strategy using engineered lentiviral particles to introduce Cas9 RNPs and a CAR transgene into primary human T cells without electroporation.
[Cell Reports]

Full Article

NK Cells Integrate Signals over Large Areas When Building Immune Synapses but Require Local Stimuli for Degranulation

Scientists generated artificial immune synapses consisting of synthetic and natural ligands for the NK cell-activating receptors LFA-1 and CD16 by microcontact printing the ligands into circular-shaped signaling proteins rearrange into supramolecular activation clusters structures.
[Science Signaling]

Full Article

MicroRNA-200c Restoration Reveals a Cytokine Profile to Enhance M1 Macrophage Polarization in Breast Cancer

To determine how TNBC suppresses antitumor macrophages, scientists used microRNA-200c, a powerful repressor of epithelial-to-mesenchymal transition, to drive mesenchymal-like mouse mammary carcinoma and human TNBC cells toward a more epithelial state.
[npj Breast Cancer]

Full Article

Low-Dose CDK4/6 Inhibitors Induce Presentation of Pathway Specific MHC Ligands as Potential Targets for Cancer Immunotherapy

Researchers investigated the effects of CDK4/6i, abemaciclib and palbociclib, on the immunopeptidome at nontoxic levels in breast cancer cell lines using biochemical identification of HLA ligands followed by network analyses.
[Oncoimmunology]

Full Article

Expression of the Myeloid Inhibitory Receptor CLEC12A Correlates with Disease Activity and Cytokines in Early Rheumatoid Arthritis

Investigators postulated that CLEC12A expression on circulating myeloid cells of rheumatoid arthritis patients is associated with disease manifestations. Cell-surface, CLEC12A receptor expression was determined on circulating neutrophils and monocytes of eRA patients and of healthy donors.
[Scientific Reports]

Abstract

This webinar provides insights and techniques for efficient leukopak sample processing and streamlined cell isolation.

REVIEWS

Immune Cells and Immunotherapy for Cardiac Injury and Repair

Scientists review the immune response to heart injury, its contribution to cardiac fibrosis, and the potential of immune modifying therapies to affect cardiac repair.
[Circulation Research]

Full Article

Is There a Place for CAR-T Cells in the Treatment of Chronic Autoimmune Rheumatic Diseases?

The authors introduce CAR-T cell technology, describe the meaningful achievements of CAR-T cells observed in onco-hematology and discuss preliminary data obtained with CAR-T cells and their derivative constructions in experimental models of autoimmune diseases.
[Arthritis & Rheumatology]

Abstract

INDUSTRY AND POLICY NEWS

Transgene and BioInvent Receive IND Approval from the US FDA for BT-001, a Novel Oncolytic Virus for the Treatment of Solid Tumors

Transgene and BioInvent International AB announce that their Investigational New Drug application for BT-001 has been granted by the US FDA. This IND will allow patients in the US to be enrolled into the ongoing Phase I/IIa clinical trial of this novel oncolytic virus BT-001.
[Transgene]

Press Release

Clarus Therapeutics and HavaH Therapeutics Announce Licensing Agreement for Product to Treat Androgen-Dependent Inflammatory Breast Disease and Certain Forms of Breast Cancer

Clarus Therapeutics, Inc. and HavaH Therapeutics announced a licensing agreement whereby Clarus will acquire the development and commercialization rights for CLAR-121. If approved, CLAR-121 would be the first T treatment of its kind for inflammatory breast disease, including estrogen receptor-positive breast cancer.
[Clarus Therapeutics, Inc. (PR Newsire, Inc.)]

Press Release

FEATURED EVENT

Microbial Exposure during Early Human Development Primes Fetal Immune Cells

Single-Cell Transcriptome Analysis Identifies Skin-Specific T-Cell Responses in Systemic Sclerosis

Impact of Rare and Common Genetic Variation in the Interleukin-1 Pathway on Human Cytokine Responses

Single Cell Characterization of the Immune Microenvironment of Melanoma Brain and Leptomeningeal Metastases

Dysregulated Immunity in PID Patients with Low GARP Expression on Tregs Due to Mutations in LRRC32

Pro-Resolving Lipid Mediator Lipoxin A4 Attenuates Neuro-Inflammation by Modulating T Cell Responses and Modifies the Spinal Cord Lipidome

Targeted Delivery of CRISPR-Cas9 and Transgenes Enables Complex Immune Cell Engineering

NK Cells Integrate Signals over Large Areas When Building Immune Synapses but Require Local Stimuli for Degranulation

MicroRNA-200c Restoration Reveals a Cytokine Profile to Enhance M1 Macrophage Polarization in Breast Cancer

Low-Dose CDK4/6 Inhibitors Induce Presentation of Pathway Specific MHC Ligands as Potential Targets for Cancer Immunotherapy

Expression of the Myeloid Inhibitory Receptor CLEC12A Correlates with Disease Activity and Cytokines in Early Rheumatoid Arthritis

Immune Cells and Immunotherapy for Cardiac Injury and Repair

Is There a Place for CAR-T Cells in the Treatment of Chronic Autoimmune Rheumatic Diseases?

Transgene and BioInvent Receive IND Approval from the US FDA for BT-001, a Novel Oncolytic Virus for the Treatment of Solid Tumors

Clarus Therapeutics and HavaH Therapeutics Announce Licensing Agreement for Product to Treat Androgen-Dependent Inflammatory Breast Disease and Certain Forms of Breast Cancer

ImmunMon 2021 Annual Symposium

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Postdoctoral Scientist – Gene Therapy

Postdoctoral Fellow – Translational Cancer Research

Faculty Positions – Immuno-Oncology

Assistant Professor – Human Innate Immunology

Postdoctoral Fellow – Cancer Immunology and Immunotherapy

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