Human Immunology News Volume 9.22 | Jun 8 2021

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    2021-06-08 | HIN 9.22


    Human Immunology News by STEMCELL Technologies
    Vol. 9.22 – 8 June, 2021
    TOP STORY

    MET Amplification Attenuates Lung Tumor Response to Immunotherapy by Inhibiting STING

    Scientists examined 81 lung cancer patients under immune checkpoint blockade (ICB) treatment and found that patients with MET amplification were resistant to ICB and had a poor progress-free survival.
    [Cancer Discovery]

    Abstract


    Learn about immunological considerations for hPSC banking by watching Dr. David Turner's webinar from the Nature Research Round Table on hPSC Quality
    PUBLICATIONSRanked by the impact factor of the journal

    Interactions between Cancer Cells and Immune Cells Drive Transitions to Mesenchymal-Like States in Glioblastoma

    Investigators dissected glioblastoma-to-microenvironment interactions by single-cell RNA sequencing analysis of human tumors and model systems, combined with functional experiments.
    [Cancer Cell]

    AbstractGraphical Abstract

    Oncogene-Induced Maladaptive Activation of Trained Immunity in the Pathogenesis and Treatment of Erdheim-Chester Disease

    Researchers revealed oncogene-induced, maladaptive induction of trained immunity in the pathogenesis of a human inflammatory myeloid neoplasm, Erdheim-Chester disease, characterized by the BRAFV600E oncogenic mutation in monocyte/macrophages and excess cytokine production.
    [Blood]

    Abstract

    Activated Natural Killer Cells Predict Poor Clinical Prognosis in High-Risk B- and T-Cell Acute Lymphoblastic Leukemia

    The authors delineated the phenotypic and functional defects in NK cells of high-risk B- and T- cell acute lymphoblastic leukemia (ALL) patients using mass, flow, and in silico cytometry, with the goal of further elucidating the role of NK cells in sustaining ALL regression.
    [Blood]

    Abstract

    GATA3 Induces Mitochondrial Biogenesis in Primary Human CD4+ T Cells during DNA Damage

    Investigators showed a mechanism utilized by CD4+ T cells to increase mitochondrial mass in response to DNA damage through the actions of GATA3 and AMPK.
    [Nature Communications]

    Full Article

    Genetic Variation Associated with Thyroid Autoimmunity Shapes the Systemic Immune Response to PD-1 Checkpoint Blockade

    The authors studied endocrine immune related adverse events from seven clinical trials across six cancers where atezolizumab was combined with chemotherapies and compared to standard of care.
    [Nature Communications]

    Full Article

    Histone Deficiency and Accelerated Replication Stress in T Cell Aging

    Scientists showed that naive T cells from older individuals as well as miR-181ab1–deficient murine T cells developed excessive replication stress after activation, due to reduced histone expression and delayed S-phase cell cycle progression.
    [Journal of Clinical Investigation]

    Full ArticleGraphical Abstract

    Bifunctional TGF-β Trap/IL-15 Protein Complex Elicits Potent NK Cell and CD8+ T Cell Immunity against Solid Tumors

    Investigators described the creation of a heterodimeric bifunctional fusion molecule, HCW9218, constructed using the soluble tissue factor-based scaffold technology. This complex comprised extracellular domains of the human transforming growth factor-β receptor II and a human interleukin (IL)-15/IL-15 receptor α complex.
    [Molecular Therapy]

    AbstractGraphical Abstract

    HTNV Infection of CD8+ T Cells Is Associated with Disease Progression in HFRS Patients

    The authors showed that Hantaan viruses (HTNV) could infect CD8+ T cells in vivo in patients diagnosed with hemorrhagic fever with renal syndrome.
    [Communications Biology]

    Full Article

    Human Immune System Adaptations to Simulated Microgravity Revealed by Single-Cell Mass Cytometry

    Researchers employed a high-dimensional mass cytometry approach to characterize over 250 cell-specific functional responses in 18 innate and adaptive immune cell subsets exposed to 1G or simulated µG using the Rotating Wall Vessel.
    [Scientific Reports]

    Full Article

    Ex Vivo Immune Profiling in Patient Blood Enables Quantification of Innate Immune Effector Functions

    Lab-based immune profiling often relies solely on quantification of cell numbers, scientists used an ex vivo whole-blood infection model in combination with biomathematical modeling to quantify functional parameters of innate immune cells in blood from patients undergoing cardiac surgery.
    [Scientific Reports]

    Full Article

    Human-Derived Treg and MSC Combination Therapy May Augment Immunosuppressive Potency In Vitro, but Did Not Improve Blood Brain Barrier Integrity in an Experimental Rat Traumatic Brain Injury Model

    Researchers compared the ability of regulatory T cells (Treg) + mesenchymal stromal cells (MSC) combination therapy, as well as MSC and Treg monotherapies, to improve blood brain barrier permeability in vivo and suppress inflammation in vitro.
    [PLOS One]

    Full Article

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    REVIEWS

    Interleukins in Cancer: From Biology to Therapy

    Interleukins can nurture an environment enabling and favoring cancer growth while simultaneously being essential for a productive tumor-directed immune response. These properties of interleukins can be exploited to improve immunotherapies to promote effectiveness as well as to limit side effects.
    [Nature Reviews Cancer]

    Full Article

    The Role of T Cells in Age-Related Diseases

    Scientists present different mechanisms by which T cells contribute to inflammaging and might act as modulators of age-associated diseases, including through enhanced pro-inflammatory and cytotoxic activity, defective clearance of senescent cells or regulation of the gut microbiota.
    [Nature Reviews Immunology]

    Abstract

    INDUSTRY AND POLICY NEWS

    Virios Therapeutics Announces Dosing of First Patient in Phase IIb Trial Evaluating IMC-1 in Patients with Fibromyalgia

    Virios Therapeutics, Inc. dosing of the first patient in its Phase IIb clinical trial, referred to as (Fibromyalgia Outcome Research Trial Evaluating Synergistic Suppression of HSV-1) FORTRESS, evaluating IMC-1 in patients with fibromyalgia.
    [Virios Therapeutics, Inc.]

    Press Release

    FEATURED EVENT

    International Conference on Malignant Lymphoma (ICML)

    June 18 – 22, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Principal Investigators – Immune Therapies and Systemic Immunology

    Shanghai Immune Therapy Institute – Shanghai, China

    Postdoctoral Scientist – Gene Therapy

    Cedars Sinai – Los Angeles, California, United States

    Postdoctoral Fellow – Translational Cancer Research

    Icahn School of Medicine at Mount Sinai – New York City, New York, United States

    Faculty Positions – Immuno-Oncology

    Medical College of Wisconsin – Milwaukee, Wisconsin, United States

    Assistant Professor – Human Innate Immunology

    Icahn School of Medicine at Mount Sinai – New York City, New York, United States

    > See All Jobs

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