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| Scientists examined 81 lung cancer patients under immune checkpoint blockade (ICB) treatment and found that patients with MET amplification were resistant to ICB and had a poor progress-free survival. [Cancer Discovery] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators dissected glioblastoma-to-microenvironment interactions by single-cell RNA sequencing analysis of human tumors and model systems, combined with functional experiments. [Cancer Cell] |
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| Researchers revealed oncogene-induced, maladaptive induction of trained immunity in the pathogenesis of a human inflammatory myeloid neoplasm, Erdheim-Chester disease, characterized by the BRAFV600E oncogenic mutation in monocyte/macrophages and excess cytokine production. [Blood] |
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| The authors delineated the phenotypic and functional defects in NK cells of high-risk B- and T- cell acute lymphoblastic leukemia (ALL) patients using mass, flow, and in silico cytometry, with the goal of further elucidating the role of NK cells in sustaining ALL regression. [Blood] |
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| Investigators showed a mechanism utilized by CD4+ T cells to increase mitochondrial mass in response to DNA damage through the actions of GATA3 and AMPK. [Nature Communications] |
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| The authors studied endocrine immune related adverse events from seven clinical trials across six cancers where atezolizumab was combined with chemotherapies and compared to standard of care. [Nature Communications] |
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| Scientists showed that naive T cells from older individuals as well as miR-181ab1–deficient murine T cells developed excessive replication stress after activation, due to reduced histone expression and delayed S-phase cell cycle progression. [Journal of Clinical Investigation] |
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| Investigators described the creation of a heterodimeric bifunctional fusion molecule, HCW9218, constructed using the soluble tissue factor-based scaffold technology. This complex comprised extracellular domains of the human transforming growth factor-β receptor II and a human interleukin (IL)-15/IL-15 receptor α complex. [Molecular Therapy] |
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| The authors showed that Hantaan viruses (HTNV) could infect CD8+ T cells in vivo in patients diagnosed with hemorrhagic fever with renal syndrome. [Communications Biology] |
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| Researchers employed a high-dimensional mass cytometry approach to characterize over 250 cell-specific functional responses in 18 innate and adaptive immune cell subsets exposed to 1G or simulated µG using the Rotating Wall Vessel. [Scientific Reports] |
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| Lab-based immune profiling often relies solely on quantification of cell numbers, scientists used an ex vivo whole-blood infection model in combination with biomathematical modeling to quantify functional parameters of innate immune cells in blood from patients undergoing cardiac surgery. [Scientific Reports] |
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| Researchers compared the ability of regulatory T cells (Treg) + mesenchymal stromal cells (MSC) combination therapy, as well as MSC and Treg monotherapies, to improve blood brain barrier permeability in vivo and suppress inflammation in vitro. [PLOS One] |
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| Interleukins can nurture an environment enabling and favoring cancer growth while simultaneously being essential for a productive tumor-directed immune response. These properties of interleukins can be exploited to improve immunotherapies to promote effectiveness as well as to limit side effects. [Nature Reviews Cancer] |
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| Scientists present different mechanisms by which T cells contribute to inflammaging and might act as modulators of age-associated diseases, including through enhanced pro-inflammatory and cytotoxic activity, defective clearance of senescent cells or regulation of the gut microbiota. [Nature Reviews Immunology] |
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| Virios Therapeutics, Inc. dosing of the first patient in its Phase IIb clinical trial, referred to as (Fibromyalgia Outcome Research Trial Evaluating Synergistic Suppression of HSV-1) FORTRESS, evaluating IMC-1 in patients with fibromyalgia. [Virios Therapeutics, Inc.] |
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| June 18 – 22, 2021 Virtual |
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| Shanghai Immune Therapy Institute – Shanghai, China |
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| Cedars Sinai – Los Angeles, California, United States |
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| Icahn School of Medicine at Mount Sinai – New York City, New York, United States |
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| Medical College of Wisconsin – Milwaukee, Wisconsin, United States |
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| Icahn School of Medicine at Mount Sinai – New York City, New York, United States |
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