Human Immunology News Volume 9.23 | Jun 15 2021

    0
    79






    2021-06-15 | HIN 9.23


    Human Immunology News by STEMCELL Technologies
    Vol. 9.23 – 15 June, 2021
    TOP STORY

    Human Oral Mucosa Cell Atlas Reveals a Stromal-Neutrophil Axis Regulating Tissue Immunity

    To aid in understanding tissue-specific pathophysiology, researchers compiled a single-cell transcriptome atlas of human oral mucosa in healthy individuals and patients with periodontitis.
    [Cell]

    AbstractGraphical Abstract

    Five tips for returning to the lab after time off
    PUBLICATIONSRanked by the impact factor of the journal

    Tim-4+ Cavity-Resident Macrophages Impair Anti-Tumor CD8+ T Cell Immunity

    The authors showed that metastatic disease in the pleural and peritoneal cavities was associated with poor clinical outcomes after immune checkpoint blockade therapy.
    [Cancer Cell]

    AbstractGraphical Abstract

    Targeting Monoamine Oxidase A-Regulated Tumor-Associated Macrophage Polarization for Cancer Immunotherapy

    Scientists observed monoamine oxidase A (MAO-A) induction in mouse and human tumor-associated macrophages (TAMs). MAO-A-deficient mice exhibited decreased TAM immunosuppressive functions corresponding with enhanced antitumor immunity.
    [Nature Communications]

    Full Article

    VISTA Is an Activating Receptor in Human Monocytes

    Investigators discovered two novel V-domain Ig suppressor of T cell activation (VISTA) antibodies and characterized their effects on human peripheral blood mononuclear cells by scRNA/CITE-seq.
    [Journal of Experimental Medicine]

    Full Article

    FOXA1 Overexpression Suppresses Interferon Signaling and Immune Response in Cancer

    Researchers found that FOXA1 overexpression inversely correlated with interferon signature and antigen presentation gene expression in prostate cancer and breast cancer patients.
    [Journal of Clinical Investigation]

    AbstractGraphical Abstract

    Role of Tumor-Infiltrating B Cells in Clinical Outcome of Patients with Melanoma Treated With Dabrafenib Plus Trametinib

    B cells may serve as a potential biomarker to predict clinical outcome in patients with advanced melanoma treated with dabrafenib plus trametinib.
    [Clinical Cancer Research]

    Abstract

    Characteristics and Spatially-Defined Immune (Micro)landscapes of Early-Stage PD-L1-Positive Triple-Negative Breast Cancer

    A large cohort of chemotherapy-naïve triple-negative breast cancer (TNBC), clinicopathologic features, deconvoluted RNA immune signatures, and intraepithelial and stromal TIME were identified in subsets of PD-L1+ and PD-L1- TNBC.
    [Clinical Cancer Research]

    Abstract

    The Dynamic Epigenetic Regulation of the Inactive X Chromosome in Healthy Human B Cells Is Dysregulated in Lupus Patients

    Scientists used RNA fluorescence in situ hybridization and immunofluorescence to profile epigenetic features of the inactive X at the single-cell level in human B cell subsets from pediatric and adult systemic lupus erythematous patients and healthy controls.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    A DL-4- and TNFα-Based Culture System to Generate High Numbers of Nonmodified or Genetically Modified Immunotherapeutic Human T-lymphoid Progenitors

    The authors provided a clinically suitable cell culture platform to generate high numbers of clinically potent nonmodified or genetically modified human T-lymphoid progenitors for accelerating immune recovery after hematopoietic stem cell transplantation and for T-cell-based immunotherapy.
    [Cellular & Molecular Immunology]

    Full Article

    Human Immune System Adaptations to Simulated Microgravity Revealed by Single-Cell Mass Cytometry

    Investigators employed a high-dimensional mass cytometry approach to characterize over 250 cell-specific functional responses in 18 innate and adaptive immune cell subsets exposed to 1G or simulated µG using the Rotating Wall Vessel.
    [Scientific Reports]

    Full Article

    Insulin Resistance Is Linked to a Specific Profile of Immune Activation in Human Subjects

    Researchers tested the hypothesis that a particular immune activation profile might be correlated with insulin resistance in a general population. 

    [Scientific Reports]

    Full Article

    Virtual Conference Exhibition: Immunology
    REVIEWS

    TCF1 in T Cell Immunity: A Broadened Frontier

    The authors summarize the key findings on TCF1 across the fields of T cell immunity and reflect on the possibility of exploring TCF1 and its downstream transcriptional programmes as therapeutic targets for improving antiviral and antitumour immunity.
    [Nature Reviews Immunology]

    Abstract

    Insights from Integrating Clinical and Preclinical Studies Advance Understanding of Graft-versus-Host Disease

    Scientists review selected recent advances both in preclinical experimental transplantation and translational human studies, including new insights into human immunology, the microbiome, and regenerative medicine.
    [Journal of Clinical Investigation]

    Abstract

    Bispecific Immunomodulatory Antibodies for Cancer Immunotherapy

    Investigators focus on emerging and novel mechanisms of action of bispecific antibodies interacting with immune cells with at least one of their arms to regulate the activity of the immune system by redirecting and/or reactivating effector cells toward tumor cells.
    [Clinical Cancer Research]

    Abstract

    INDUSTRY AND POLICY NEWS

    ONK Therapeutics and Trinity College Dublin Collaborate in an Enterprise Ireland Funded Project to Optimize Metabolism of NK Cells for Improved Cancer Therapies

    ONK Therapeutics Ltd announced that it has been awarded an Innovation Partnership Programme grant by Enterprise Ireland to fund collaborative research at Trinity College Dublin, Ireland, led by Dr. David Finlay to optimize the metabolism and engineering of NK cells for improved cancer therapies.
    [ONK Therapeutics, Ltd.]

    Press Release

    4D pharma Completes Enrollment of Part A of the Phase I/II Trial of MRx-4DP0004 for the Treatment of Asthma and Provides Program Update

    4D pharma plc announced the completion of its target enrollment of 30 patients for Part A of its Phase I/II clinical trial of MRx-4DP0004 in patients with partly-controlled asthma.
    [4D pharma plc]

    Press Release

    FEATURED EVENT

    Innovative Vaccine Approaches

    June 28 – 30, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Immunology or Bacteriology

    Brigham and Women’s Hospital – Boston, Massachusetts, United States

    Research Associate – Neuroinflammatory Signaling

    University of Bristol- Bristol, England, United Kingdom

    Postdoctoral Student – T Cell-B Cell Interactions

    European School of Molecular Medicine – Milan & Naples, Italy

    Program Co-Leader – Immunology

    The Wistar Institute – Philadelphia, Pennsylvania, United States

    Postdoctoral Fellow – Translational Cancer Research

    Icahn School of Medicine at Mount Sinai – New York City, New York, United States

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Human Immunology News Twitter