Human Immunology News Volume 9.24 | Jun 22 2021

    By
    Justin.choi
    -
    0
    64






    2021-06-22 | HIN 9.24


    Human Immunology News by STEMCELL Technologies
    Vol. 9.24 – 22 June, 2021
    TOP STORY

    Tissue-Resident Macrophages Provide a Pro-Tumorigenic Niche to Early NSCLC Cells

    Researchers identified distinct populations of macrophages that were enriched in human and mouse lung tumors.
    [Nature]

    Abstract

    The STEMdiffâ„¢ Monocyte Kit generates millions of monocytes ready for downstream assays or further development into macrophages or dendritic cells.
    PUBLICATIONSRanked by the impact factor of the journal

    ctDNA Guiding Adjuvant Immunotherapy in Urothelial Carcinoma

    Scientists evaluated outcomes in 581 patients who had undergone surgery and were evaluable for ctDNA from a randomized Phase III trial of adjuvant atezolizumab versus observation in operable urothelial cancer.
    [Nature]

    Abstract

    Bifidobacteria-Mediated Immune System Imprinting Early in Life

    The authors showed that a lack of bifidobacteria, and in particular depletion of genes required for human milk oligosaccharide utilization from the metagenome, was associated with systemic inflammation and immune dysregulation early in life.
    [Cell]

    Full ArticleGraphical Abstract

    Expansion of Tumor-Associated Treg Cells upon Disruption of a CTLA-4-Dependent Feedback Loop

    Researchers found that the polyclonal Treg cell repertoire was pre-enriched to recognize antigens presented by tumor-associated conventional dendritic cells.
    [Cell]

    AbstractGraphical Abstract

    Targeting Regulator of G Protein Signaling 1 in Tumor-Specific T Cells Enhances Their Trafficking to Breast Cancer

    Investigators found that upregulation of regulator of G protein signaling (RGS)1 in helper TH1 cells and cytotoxic T lymphocytes (CTLs) reduced their trafficking to and survival in tumors and was associated with shorter survival of patients with breast and lung cancer.
    [Nature Immunology]

    Abstract

    Inhibition of the DNA Damage Response Phosphatase PPM1D Reprograms Neutrophils to Enhance Anti-Tumor Immune Responses

    Scientists showed that mice with genetic knockout of Ppm1d or with conditional knockout of Ppm1d in the hematopoietic system, in myeloid cells, or in neutrophils all displayed significantly reduced growth of syngeneic melanoma or lung carcinoma tumors.
    [Nature Communications]

    Full Article

    Targeting the αv Integrin-TGF-β Axis Improves Natural Killer Cell Function against Glioblastoma Stem Cells

    The authors showed that glioblastoma stem cells, but not normal astrocytes, were sensitive to lysis by healthy allogeneic natural killer cells in vitro.
    [Journal of Clinical Investigation]

    AbstractFull ArticlePress ReleaseGraphical
    Abstract

    Maintenance of the Human Memory T Cell Repertoire by Subset and Tissue Site

    Investigators showed that the human memory T cell repertoire comprised clones which persisted across sites and subsets, along with clones that were more restricted to certain subsets and/or tissue sites.
    [Genome Medicine]

    Full Article

    HIF-1α Is a Negative Regulator of Interferon Regulatory Factors: Implications for Interferon Production by Hypoxic Monocytes

    To understand the pathophysiology of COVID-19 infection, it is necessary to understand cell function during hypoxia. Researchers investigated aspects of human monocyte activation under hypoxic conditions.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Full Article

    MYC-Mediated Early Glycolysis Negatively Regulates Proinflammatory Responses by Controlling IRF4 in Inflammatory Macrophages

    Metabolic and molecular analyses reveal that MYC, but not hypoxia inducible factor 1, was involved in enhancing early glycolytic flux during inflammatory macrophage polarization.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Ionizing Radiation Curtails Immunosuppressive Effects from Cancer-Associated Fibroblasts on Dendritic Cells

    Scientists investigated the effects of ionizing radiation on cancer-associated fibroblast (CAF)-mediated regulation of dendritic cells (DCs). CAFs were obtained from freshly operated lung cancer tissues, while DCs were procured from peripheral blood of healthy donors.
    [Frontiers in Immunology]

    Full Article

    The Immunology Podcast is here. Find it wherever you get your podcasts.
    REVIEWS

    Interferon-γ: Teammate or Opponent in the Tumor Microenvironment?

    The authors review the cells that produce IFNγ and the different effects of IFNγ in the tumor microenvironment, highlighting the pleiotropic nature of this multifunctional and abundant cytokine.
    [Nature Reviews Immunology]

    Abstract

    Not-So-Opposite Ends of the Spectrum: CD8+ T Cell Dysfunction across Chronic Infection, Cancer and Autoimmunity

    A better understanding of these CD8+ T cell states may reveal novel strategies to augment clearance of chronic viral infection and cancer and to mitigate self-reactivity leading to tissue damage in autoimmunity.
    [Nature Immunology]

    Full Article

    Cancer Immunotherapy: It’s Time to Better Predict Patients’ Response

    The authors critically discuss current knowledge regarding predictive biomarkers for checkpoint inhibitor-based immunotherapy, highlight the missing/unclear links and emphasise the importance of characterising each neoplasm and its microenvironment in order to better guide the course of treatment.
    [British Journal of Cancer]

    Abstract

    INDUSTRY AND POLICY NEWS

    FibroGen and HiFiBiO Announce Transformative Partnership to Advance Next-Generation Therapies for Patients with Cancer and Autoimmune Disease

    FibroGen, Inc. and HiFiBiO Therapeutics, a private, multinational clinical-stage biotherapeutics company with expertise in immune modulation and single cell science announced a partnership covering three HiFiBiO programs.
    [FibroGen, Inc.]

    Press Release

    Kytopen Awarded NIH Grant of Up to $2M to Unlock the Power of Engineered Natural Killer (NK) Cells via Flowfect® Platform

    Kytopen announced it was awarded a SBIR Fast Track grant from the National Institute of Allergy and Infectious Diseases, a part of the National Institute of Health. Kytopen is eligible for up to $2M over the course of the three-year award as project milestones are successfully completed within the Phase I and Phase II portions of the grant.
    [Kytopen]

    Press Release

    FEATURED EVENT

    European Congress of Clinical Microbiology & Infectious Diseases (ECCMID) 2021

    July 9 – 12, 2021
    Vienna, Austria

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – B Cell Immunology

    University of Gothenburg – Gothenburg, Sweden

    Senior Research Scientist/Principal Scientist – Immunology

    Hummingbird Bioscience – Singapore, Singapore

    Postdoctoral Student – T Cell-B Cell Interactions

    European School of Molecular Medicine – Milan & Naples, Italy

    Postdoctoral Fellow – Immunology or Bacteriology

    Brigham and Women’s Hospital – Boston, Massachusetts, United States

    Program Co-Leader – Immunology

    The Wistar Institute – Philadelphia, Pennsylvania, United States

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Human Immunology News Twitter