Human Immunology News Volume 9.26 | Jul 6 2021

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    2021-07-06 | HIN 9.26


    Human Immunology News by STEMCELL Technologies
    Vol. 9.26 – 6 July, 2021
    TOP STORY

    Anti-RhD Antibody Therapy Modulates Human Natural Killer Cell Function

    Mechanistically, scientists demonstrated that NK cell degranulation was mediated by binding of the Fc segment of anti-RhD antibodies to CD16, the main Fcγ receptor expressed on NK cells.
    [Haematologica]

    Full Article

    SepMate™ PBMC Isolation
    PUBLICATIONSRanked by the impact factor of the journal

    Organoid Platform in Preclinical Investigation of Personalized Immunotherapy Efficacy in Appendiceal Cancer: Feasibility Study

    Patient tumor organoids were fabricated using unsorted tumor cells with and without enrichment with patient matched immune components derived from peripheral blood leukocytes, spleen, or lymph nodes.
    [Clinical Cancer Research]

    Abstract

    α1-Acid Glycoprotein Enhances the Immunosuppressive and Protumor Functions of Tumor-Associated Macrophages

    Researchers revealed that α1-acid glycoprotein contributed directly to tumor development by induction of programmed death ligand 1 expression and IL-6 production in macrophages.
    [Cancer Research]

    Abstract

    High-Dimensional and Single-Cell Transcriptome Analysis of the Tumor Microenvironment in Angioimmunoblastic T Cell Lymphoma (AITL)

    Scientists utilized mass cytometry and single-cell transcriptome analysis to identify several expanded populations within the angioimmunoblastic T-cell lymphoma tumor microenvironment.
    [Leukemia]

    Abstract

    Splicing Factor SRSF1 Is Indispensable for Regulatory T Cell Homeostasis and Function

    Researchers showed that serine/arginine-rich splicing factor 1, which was decreased in T cells from patients with systemic lupus erythematosus, was necessary for the homeostasis and proper function of Treg cells.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Morphological Profiling of Human T and NK Lymphocytes by High-Content Cell Imaging

    The authors demonstrated the applicability of high-content imaging to human T and natural killer (NK) cells and developed a pipeline for unbiased analysis of high-definition morphological profiles.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Differential Effects of Estradiol and Progesterone on Human T Cell Activation In Vitro

    Researchers reported a direct comparison of estradiol- and progesterone-mediated effects on human CD4+ T cells, key cells in immune regulation. T cells were stimulated to obtain different levels of activation and exposed to a broad range of hormone concentrations.
    [European Journal of Immunology]

    Abstract

    Multipotent Adult Progenitor Cells Induce Regulatory T Cells and Promote Their Suppressive Phenotype via TGFβ and Monocyte-Dependent Mechanisms

    Investigators demonstrated that, in an in vitro setting, MAPC cells increase Treg frequencies by promoting Treg proliferation and CD4+ T cell differentiation into Tregs.
    [Scientific Reports]

    Full Article

    Acetaldehyde Exposure Underlies Functional Defects in Monocytes Induced by Excessive Alcohol Consumption

    Blood and fecal samples were collected on admission and four weeks after alcohol cessation and were sequentially analyzed. Wild-type and ALDH2*2 transgenic mice were used to examine the effect of acetaldehyde exposure on liver immune responses.
    [Scientific Reports]

    Full Article

    Chemotherapy Induces Canalization of Cell State in Childhood B-Cell Precursor Acute Lymphoblastic Leukemia

    Scientists investigated the mechanisms of selection in childhood B cell precursor acute lymphoblastic leukemia during induction chemotherapy where maximal cytoreduction occurs.
    [Nature Cancer]

    Abstract

    Cell Preparation For Crossmatch Assays
    REVIEWS

    Neutrophils in Cancer: Heterogeneous and Multifaceted

    Scientists describe how neutrophil diversification, which in some contexts can lead to opposing functions, is generated within the tumor microenvironment as well as systemically.
    [Nature Reviews Immunology]

    Abstract

    Immunomodulation by Radiotherapy in Tumor Control and Normal Tissue Toxicity

    The full scope of radiotherapy-induced immune changes remains unclear but is likely to involve multiple components, such as immune cells, the extracellular matrix, endothelial and epithelial cells and a myriad of chemokines and cytokines, including transforming growth factor-β.
    [Nature Reviews Immunology]

    Abstract

    Insights into the Biology and Therapeutic Implications of TNF and Regulatory T Cells

    Some patients do not respond to TNF inhibitor treatment and rare occurrences of paradoxical disease exacerbation have been reported. These limitations on the clinical efficacy of TNF inhibitors can be explained by the differences between TNF receptor 1 (TNFR1) and TNFR2 signaling and by the diverse effects of TNF on multiple immune cells, including FOXP3+ regulatory T cells.
    [Nature Reviews Rheumatology]

    Abstract

    INDUSTRY AND POLICY NEWS

    Abcuro and ImaginAb Share Initial Results of Study Using Novel Technology for Imaging T Cell Infiltration of Skeletal Muscle in Patients with Inclusion Body Myositis

    Abcuro, Inc. and ImaginAb shared initial results of a study demonstrating the use of ImmunoPET technology to image T cell infiltration of skeletal muscle in patients with inclusion body myositis, an autoimmune disease in which cytotoxic CD8+ T cells chronically attack muscle cells, leading to progressive weakness and severe disability.
    [Abcuro, Inc.]

    Press Release

    FEATURED EVENT

    Melbourne Immunotherapy Network (MIN)

    August 6 – 7, 2021
    Marysville, Victoria, Australia

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Associate – Translational Immunology and Immunotherapy

    Roswell Park – Colorado Springs, Colorado, United States

    PhD Student – Targeted Leukemia Prevention

    Heinrich Heine University Düsseldorf – Düsseldorf, Germany

    Postdoctoral Position – Modeling Autism Spectrum Disorder

    Weill Cornell Medical College – New York, New York, United States

    Senior Research Scientist/Principal Scientist – Immunology

    Hummingbird Bioscience – Singapore, Singapore

    Postdoctoral Fellow – B Cell Immunology

    University of Gothenburg – Gothenburg, Sweden

    > See All Jobs

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