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| Mechanistically, scientists demonstrated that NK cell degranulation was mediated by binding of the Fc segment of anti-RhD antibodies to CD16, the main Fcγ receptor expressed on NK cells. [Haematologica] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Patient tumor organoids were fabricated using unsorted tumor cells with and without enrichment with patient matched immune components derived from peripheral blood leukocytes, spleen, or lymph nodes. [Clinical Cancer Research] |
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| Researchers revealed that α1-acid glycoprotein contributed directly to tumor development by induction of programmed death ligand 1 expression and IL-6 production in macrophages. [Cancer Research] |
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| Scientists utilized mass cytometry and single-cell transcriptome analysis to identify several expanded populations within the angioimmunoblastic T-cell lymphoma tumor microenvironment. [Leukemia] |
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| Researchers showed that serine/arginine-rich splicing factor 1, which was decreased in T cells from patients with systemic lupus erythematosus, was necessary for the homeostasis and proper function of Treg cells. [Cell Reports] |
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| The authors demonstrated the applicability of high-content imaging to human T and natural killer (NK) cells and developed a pipeline for unbiased analysis of high-definition morphological profiles. [Cell Reports] |
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| Researchers reported a direct comparison of estradiol- and progesterone-mediated effects on human CD4+ T cells, key cells in immune regulation. T cells were stimulated to obtain different levels of activation and exposed to a broad range of hormone concentrations. [European Journal of Immunology] |
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| Investigators demonstrated that, in an in vitro setting, MAPC cells increase Treg frequencies by promoting Treg proliferation and CD4+ T cell differentiation into Tregs. [Scientific Reports] |
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| Blood and fecal samples were collected on admission and four weeks after alcohol cessation and were sequentially analyzed. Wild-type and ALDH2*2 transgenic mice were used to examine the effect of acetaldehyde exposure on liver immune responses. [Scientific Reports] |
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| Scientists investigated the mechanisms of selection in childhood B cell precursor acute lymphoblastic leukemia during induction chemotherapy where maximal cytoreduction occurs. [Nature Cancer] |
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| Scientists describe how neutrophil diversification, which in some contexts can lead to opposing functions, is generated within the tumor microenvironment as well as systemically. [Nature Reviews Immunology] |
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| The full scope of radiotherapy-induced immune changes remains unclear but is likely to involve multiple components, such as immune cells, the extracellular matrix, endothelial and epithelial cells and a myriad of chemokines and cytokines, including transforming growth factor-β. [Nature Reviews Immunology] |
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| Some patients do not respond to TNF inhibitor treatment and rare occurrences of paradoxical disease exacerbation have been reported. These limitations on the clinical efficacy of TNF inhibitors can be explained by the differences between TNF receptor 1 (TNFR1) and TNFR2 signaling and by the diverse effects of TNF on multiple immune cells, including FOXP3+ regulatory T cells. [Nature Reviews Rheumatology] |
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| Abcuro, Inc. and ImaginAb shared initial results of a study demonstrating the use of ImmunoPET technology to image T cell infiltration of skeletal muscle in patients with inclusion body myositis, an autoimmune disease in which cytotoxic CD8+ T cells chronically attack muscle cells, leading to progressive weakness and severe disability. [Abcuro, Inc.] |
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| August 6 – 7, 2021 Marysville, Victoria, Australia |
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| Roswell Park – Colorado Springs, Colorado, United States |
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| Heinrich Heine University Düsseldorf – Düsseldorf, Germany |
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| Weill Cornell Medical College – New York, New York, United States |
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| Hummingbird Bioscience – Singapore, Singapore |
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| University of Gothenburg – Gothenburg, Sweden |
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