| Vol. 9.27 – 13 July, 2021 |
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| Researchers quantified the NK cell responsiveness of hundreds of molecularly annotated ‘DNA-barcoded’ solid tumor cell lines in multiplexed format and applied genome-scale CRISPR-based gene-editing screens in several solid tumor cell lines, to functionally interrogate which genes in tumor cells regulated the response to NK cells. [Nature Genetics] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| T-cell-derived nanovesicles produced by the serial extrusion of cytotoxic T cells through membranes with micro-/nanosized pores that inhibited T-cell exhaustion and exhibited antitumoral activity maintained in the immunosuppressive tumor microenvironment were presented. [Advanced Materials] |
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| The authors revealed a frequent activation of RelB in a large cohort of diffuse large B-cell lymphoma patients and cell lines, independently of their ABC or GCB subtypes. [Blood] |
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| To identify and interrogate malignant clones in matched skin and blood from leukemic MF and SS patients, scientists combined T cell receptor clonotyping, with quantification of gene expression and cell surface markers at the single cell level. [Blood] |
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| Researchers observed that tumor cell intrinsic loss of A20 markedly enhanced lung tumorigenesis and was associated with reduced CD8+ T cell–mediated immune surveillance in patients with lung cancer and in mouse models. [Science Translational Medicine] |
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| Scientists showed that butyrophilin 2A1 (BTN2A1) was required for BTN3A-mediated Vγ9Vδ2 T cell cytotoxicity against cancer cells, and that expression of the BTN2A1/BTN3A1 complex was sufficient to trigger Vγ9Vδ2 TCR activation. [Cell Reports] |
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| Researchers demonstrated the single-stranded DNA state in the 23 bp E2A fragile zone using several methods, including native bisulfite DNA structural analysis in live human pre-B cells. [Cell Reports] |
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| Investigators showed that LTB4 and its synthesizing enzymes localize to intracellular multivesicular bodies, which, upon stimulation, released their content as exosomes. [PLOS Biology] |
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| Scientists quantified peptide repertoire breadth of a representative set of human leukocyte antigen class I (HLA-I) alleles and found that patients with cancer who were carrying HLA-I alleles with high peptide-binding promiscuity had significantly worse prognosis after immune checkpoint inhibition. [Nature Cancer] |
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| The authors review the known functions of B-cells in the tumor microenvironment, the contribution of B-cells to the anti-tumor activity of immunotherapies, and the role of B-cells in the overall survival of cancer patients. [Clinical Cancer Research] |
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| Nomenclature reflecting the mutually opposing nature of T-cell self-renewal and T-cell differentiation would help synchronize phenomena such as T-cell memory, protective immunity, and T-cell exhaustion with other regenerative paradigms, as well as offer new strategies to influence the intensity and duration of immunity. [Cold Spring Harbor Perspectives in Biology] |
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| Alector, Inc. and GlaxoSmithKline plc announced a strategic global collaboration for the development and commercialization of two clinical-stage, potential first-in-class monoclonal antibodies designed to elevate progranulin levels. [Alector, Inc.] |
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| Developmental biologist and immunologist Maria Leptin will be the next president of the European Research Council (ERC), the ERC’s Scientific Council announced. Leptin will take over in October from Interim President Jean-Pierre Bourguignon, who has been leading the ERC since Mauro Ferrari resigned from the post in April 2020 after a dispute over how the organization should fund research on COVID-19. [The Scientist] |
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| August 1 – 2, 2021 Brisbane, Australia |
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| Mercer University – Savannah, Georgia, United States |
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| University of North Dakota – Grand Forks, North Dakota, United States |
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| Medical College of Wisconsin – Milwaukee, Wisconsin, United States |
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| Heinrich Heine University Düsseldorf – Düsseldorf, Germany |
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| Weill Cornell Medical College – New York, New York, United States |
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