 | | Vol. 9.28 – 20 July, 2021 |
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| Scientists screened 19,050 human genes by CRISPR-Cas9 mutagenesis and identified interferon-gamma–induced apolipoprotein L3 as a potent bactericidal agent protecting multiple non–immune barrier cell types against infection.
[Science] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Using highly multiplexed peptide-MHC tetramer staining of unexpanded cells from blood, liver, and tumor tissues from 46 hepatocellular carcinoma patients, researchers detected 91 different antigen-specific CD8+ T cell populations targeting hepatitis B virus (HBV), neoantigen, tumor-associated, and disease-unrelated antigens.
[Immunity] |
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| Overexpression of basic leucine zipper ATF-like transcription factor (BATF) in CD8+ T cells expressing a chimeric antigen receptor (CAR) promoted the survival and expansion of tumor-infiltrating CAR T cells, increased the production of effector cytokines, and decreased the expression of inhibitory receptors.
[Nature Immunology] |
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| The authors showed that clinically applied adenovirus vectors preferentially targeted fibroblastic stromal cells in cultured human tissues.
[Nature Immunology] |
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| In humans, JAK3 and γc deficiencies resulted in severe combined immunodeficiency characterized by an absence of T cells, natural killer cells, innate lymphoid cells, and presumably lymphoid tissue inducer cells.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| A polygenic-risk-score (PRS) of 41 CLL-susceptibility variants has been found to be associated with CLL risk among individuals of European-ancestry. Scientists evaluated these variants, the PRS, and environmental factors for monoclonal B-cell lymphocytosis risk.
[Leukemia] |
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| The authors reported the development of a highly sensitive and reproducible Bio-ELISA to quantify picogram levels of tyrosine hydroxylase in multiple model systems. They applied this assay to monocytes isolated from blood of persons with Parkinson’s disease and to age-matched, healthy controls.
[npj Parkinson’s Disease] |
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| Scientists performed single-cell transcriptome and TCR sequencing, and conducted integrative analyses to decode composition, function and lineage relationship of T cells in the blood and cerebrospinal fluid of Parkinson’s disease.
[Cell Discovery] |
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| The authors investigated the mechanism by which S100 calcium-binding protein A9 (S100A9) was involved in neutrophil activation, neutrophil extracellular trap-induced airway inflammation, and macrophage polarization in neutrophilic asthma.
[Experimental & Molecular Medicine] |
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| Researchers examined whether retrospective reports of adversity during childhood or pregnancy were associated with inflammatory imbalance, in an ethnically diverse cohort of 53 low-income women seeking family-based trauma treatment following exposure to interpersonal violence.
[Translational Psychiatry] |
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| The rationale and early immunobiology of CD40 as a master regulator of dendritic cell activation is reviewed, with further contextualization and appreciation for the role of CD40 stimulation not only in cancer vaccines but also in other contemporary immune-oncology approaches.
[Cellular & Molecular Immunology] |
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| OSE Immunotherapeutics SA announced a voluntary and temporary pause of enrollment and dosing in its ongoing Phase I clinical trial for CoVepiT, the company’s investigational prophylactic COVID-19 vaccine candidate.
[OSE Immunotherapeutics SA (GlobeNewswire, Inc.)] |
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| LAVA Therapeutics N.V. announced dosing of the first patient in the company’s Phase I/IIa clinical trial of LAVA-051 in patients with relapsed and/or refractory chronic lymphocytic leukemia, multiple myeloma and acute myeloid leukemia.
[LAVA Therapeutics, N.V.] |
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| August 19 – 20, 2021
Zurich, Switzerland |
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| | Aarhus University – Aarhus, Denmark |
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| | University of Wisconsin–Madison – Madison, Wisconsin, United States |
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| | Mercer University – Savannah, Georgia, United States |
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| | University of North Dakota – Grand Forks, North Dakota, United States |
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| Medical College of Wisconsin – Milwaukee, Wisconsin, United States |
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