 | | Vol. 9.29 – 27 July, 2021 |
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| Scientists showed, by linking the antigenic specificity of T cell receptors and the cellular phenotype of melanoma-infiltrating lymphocytes at single-cell resolution, that tumor specificity shaped the expression state of intratumoral CD8+ T cells.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Ten of 16 patients with large B cell lymphoma with progressive disease after CAR19 treatment had absent or low CD19.
[Nature Medicine] |
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| Investigators showed that the epigenetic state of exhaustion was largely irreversible, even after curative therapy. Analysis of chromatin accessibility in HCV- and HIV-specific responses identified a core epigenetic program of exhaustion in CD8+ T cells, which underwent only limited remodeling before and after resolution of infection.
[Nature Immunology] |
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| Researchers described a human CD137xPD-L1 bispecific antibody, MCLA-145, identified through functional screening of agonist- and immune checkpoint inhibitor arm combinations.
[Nature Communications] |
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| Type 1 diabetes (T1D) patients had a lower serum mitochondrial open reading frame of the 12S rRNA type-c (MOTS-c) level than did healthy controls. Furthermore, MOTS-c reduced T cell activation by alleviating T cells from the glycolytic stress in T1D patients, suggesting therapeutic potential.
[Cell Reports] |
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| Using primary human CD4+ T cells, researchers showed that when T cells formed immunological synapse with stimulating antibody-coated surfaces, the lamellipodia were stiffer than the cell body.
[eLife] |
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| Investigators showed the efficacy of their most potent inhibitors in activating the antitumor response using primary human immune cells from healthy donors.
[Journal of Medicinal Chemistry] |
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| Scientists reported that extracellular vesicles derived from human natural killer-92 cells stimulated with IL-15 + IL-21 showed enhanced cytotoxic capacity against tumor cells.
[Cancer Gene Therapy] |
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| The authors identified an important caveat when investigating TLR4-driven signaling in BLaER1 cells. They showed that this model contained glycosylphosphatidylinositol anchor-deficient cells, which lacked CD14 surface expression when differentiated to monocytes, resulting in diminished LPS/TLR4 but not TLR7/TLR8 responsiveness.
[Scientific Reports] |
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| Scientists observed a reduction in the levels of CD4+ T cells and an increase in both the polymorphonuclear MDSCs and Tregs.
[Scientific Reports] |
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| The authors recast unconventional T cell subsets according to the class of ligand that they recognize; their expression of semi-invariant or diverse T cell receptors; the structural features that underlie ligand recognition; their acquisition of effector functions in the thymus or periphery; and their distinct functional properties.
[Nature] |
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| Investigators discuss the migratory routes and immunological consequences of distinct dendritic cell (DC) subsets, the molecular basis and regulatory mechanisms of migratory signaling in DCs, and the association of DC migration with the pathogenesis of autoimmune and infectious diseases.
[Cellular & Molecular Immunology] |
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| Scientists summarize how T cell activation is controlled by dendritic cells and how the tumor microenvironment alters dendritic cell properties in the context of the anti-tumor immune cycle.
[Oncogene] |
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| Ottawa researchers have been awarded more than $8 million to lead four national studies in pursuit of answers about how well COVID-19 vaccines work in people with cancer and other health conditions.
[Ottawa Citizen] |
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| September 13 – 15, 2021
Virtual |
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| | University of California Irvine – Irvine, California, United States |
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| | University of Wisconsin–Madison – Madison, Wisconsin, United States |
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| | Mercer University – Savannah, Georgia, United States |
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| | University of North Dakota – Grand Forks, North Dakota, United States |
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| Medical College of Wisconsin – Milwaukee, Wisconsin, United States |
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