 | | Vol. 9.32 – 17 August, 2021 |
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| The authors showed that neutrophils from either lupus-prone mice or patients with systemic lupus erythematosus undergo ferroptosis.
[Nature Immunology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists evaluated the association of a single session of electronic cigarette (ECIG) vaping on cellular oxidative stress in immune cells in young people who do not smoke or vape compared with young people with long-term tobacco cigarette or ECIG use.
[JAMA Pediatrics] |
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| Researchers showed that human T cells engineered to express an methyl-lysophosphatidic acid (mLPA)-specific TCR, targeted diverse CD1c-expressing leukemia blasts in vitro and significantly delayed the progression of three models of leukemia xenograft in NSG mice, an effect that was boosted by mLPA-cellular immunization.
[Nature Communications] |
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| Investigators modeled tumor-specific MEK inhibition (MEKi) through CRISPR/Cas-mediated genome editing of tumor cells and pharmacologic MEKi with cobimetinib in a RAS-driven model of colorectal cancer.
[Cancer Immunology Research] |
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| Researchers reported exploratory analyses of the associations of tumor mutational burden, a four gene inflammatory gene expression signature, and BRAF mutation status with tumor response, progression-free survival, and overall survival in patients with advanced melanoma treated as part of the CheckMate 066 and 067 Phase III clinical trials evaluating immuno-oncology therapies.
[Cancer Immunology Research] |
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| By performing both whole-genome CRISPR and metabolic inhibitor screens, scientists identified that nicotinamide phosphoribosyltransferase (NAMPT) was required for T cell activation.
[Cell Reports] |
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| Using various clinically and physiologically relevant systems, researchers showed that a prominent feature of PD-1-expressing exhausted T cells was the development of cellular senescence features both in vivo and ex vivo.
[Frontiers in Immunology] |
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| Utilising an in vitro migration assay, regulatory T cells from patients with psoriatic arthritis treated with conventional therapy paradoxically boosted CCR6+ effector T cell migration towards CCL20.
[iScience] |
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| Investigators selected HULC, PVT1, MEG3, SPRY4-IT1, LINC-ROR and DSCAM-AS1 long non-coding RNAs to appraise their transcript levels in the circulation of chronic inflammatory demyelinating polyradiculoneuropathy and Guillain-Barré syndrome cases versus controls.
[Scientific Reports] |
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| Scientists demonstrated that melatonin had several significant effects by reducing CD11b and TLR4 expression, attenuating TLR signaling, genes involved in the inflammasome and had the potential to reduce LPS-induced inflammatory responses.
[Pediatric Research] |
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| The authors review key molecular mechanisms of immune cell activation implicated in modulating atherogenesis and provide an update on the contributions of innate and adaptive immune cell subsets in atherosclerosis.
[Nature Reviews Immunology] |
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| Scientists summarize recent advances in the epigenetic, genetic, and functional integrity of the IFNγ signaling pathway in the colorectal cancer microenvironment and its immunological relevance in the therapeutic efficacy of and resistance to immune checkpoint blockade.
[Cellular & Molecular Immunology] |
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| Allogene Therapeutics, Inc., a clinical-stage biotechnology company developing allogeneic CAR T therapies for cancer, announced that the US FDA has granted ODD to ALLO-715 for the treatment of MM.
[Allogene Therapeutics, Inc.] |
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| VYNE Therapeutics, Inc. announced that it has entered into an exclusive license agreement with In4Derm Limited, a spin-out of the University of Dundee’s School of Life Sciences focused on the discovery and development of proprietary Bromodomain and Extra-Terminal Domain inhibitors (BET inhibitor) for the treatment of immunology and oncology conditions.
[VYNE Therapeutics, Inc.] |
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| September 26 – October 1, 2021
Orlando, Florida, United States |
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| | Purdue University – West Lafayette, Indiana, United States |
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| Washington University School of Medicine – St. Louis, Missouri, United States |
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| | University of California Irvine – Irvine, California, United States |
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| | Queen’s University Belfast – Belfast, Northern Ireland, United Kingdom |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | Amgen – San Francisco, California, United States |
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