Human Immunology News Volume 9.33 | Aug 24 2021

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    2021-08-24 | HIN 9.33


    Human Immunology News by STEMCELL Technologies
    Vol. 9.33 – 24 August, 2021
    TOP STORY

    A Bacterial Bile Acid Metabolite Modulates Treg Activity through the Nuclear Hormone Receptor NR4A1

    Researchers identified gut bacteria that synthesized isoalloLCA from 3-oxolithocholic acid and uncovered a gene cluster responsible for the conversion in members of the abundant human gut bacterial phylum Bacteroidetes.
    [Cell Host & Microbe]

    AbstractGraphical Abstract

    Free E-Book: Genome Editing Applications for Disease Modeling and Cell Therapy.
    PUBLICATIONSRanked by the impact factor of the journal

    Clinical Implications of Inter- and Intra-Tumor Heterogeneity of Immune Cell Markers in Lung Cancer

    Using RNA sequencing in 269 tumor samples from 160 lung cancer patients researchers quantified the inter-tumor heterogeneity of immune gene expression and immune cell abundance and evaluated the association of median immune cell abundance with clinical/pathological features and overall survival.
    [Journal of the National Cancer Institute]

    Abstract

    DL4-μbeads Induce T Cell Lineage Differentiation from Stem Cells in a Stromal Cell-Free System

    The authors reported a stromal cell-free, microbead-based approach that supported the efficient in vitro development of both human progenitor T cells and T-lineage cells from CD34+ cells sourced from cord blood, GCSF-mobilized peripheral blood, and PSCs.
    [Nature Communications]

    Full ArticlePress Release

    Cas9-Derived Peptides Presented by MHC Class II That Elicit Proliferation of CD4+ T-cells

    Investigators used an MHC Associated Peptide Proteomics assay to identify SaCas9 peptides presented by MHC Class II (MHC-II) proteins on dendritic cells.
    [Nature Communications]

    Full Article

    ZFP91 Disturbs Metabolic Fitness and Antitumor Activity of Tumor-Infiltrating T Cells

    Scientists demonstrated that ZFP91 perturbed T cell metabolic and functional states in the tumor microenvironment and suggested that targeting ZFP91 may improve the efficacy of cancer immunotherapy.
    [Journal of Clinical Investigation]

    AbstractFull ArticleGraphical Abstract

    Effective Control of Large Deletions after Double-Strand Breaks by Homology-Directed Repair and dsODN Insertion

    The authors showed that large deletions were ubiquitous but were dependent on editing sites and cell types. Human primary T cells displayed more significant deletions than hematopoietic stem and progenitor cells, whereas they observed low levels in induced pluripotent stem cells.
    [Genome Biology]

    Full Article

    An Epigenetic and Transcriptomic Signature of Immune Tolerance in Human Monocytes through Multi-Omics Integration

    Researchers sought to identify epigenetic and transcriptomic features of cytokine production capacity in circulating monocytes during community-acquired pneumonia.
    [Genome Medicine]

    Full Article

    Single-Cell Transcriptome Analysis Reveals the Dynamics of Human Immune Cells during Early Fetal Skin Development

    Gene expression analysis revealed a typical developmental program in immune cells in accordance with their functional maturation, possibly involving metabolic reprogramming.
    [Cell Reports]

    Full Article

    Selective Deletion of Human Leukocyte Antigens Protects Stem Cell-Derived Islets from Immune Rejection

    Scientists used genetic engineering to create human PSCs in which the majority of the polymorphic human leukocyte antigens, the main drivers of allogeneic rejection, were deleted.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Single-Cell Analysis Reveals Divergent Responses of Human Dendritic Cells to the MVA Vaccine

    The authors examined how these diverse responses are orchestrated in human dendritic cells (DCs). Single-cell analyses revealed that the response to modified vaccinia virus Ankara infection in DCs was limited to early viral gene expression.
    [Science Signaling]

    Abstract

    Comparative Analysis of TCR and CAR Signaling Informs CAR Designs with Superior Antigen Sensitivity and In Vivo Function

    To design CARs with a lower activation threshold, scientists compared antigen-induced pathway signaling in human T cells expressing a current CAR construct to that in cells with endogenous T cell receptors (TCRs).
    [Science Signaling]

    Full Article

    Immunomodulation by Durvalumab and Pomalidomide in Patients with Relapsed/Refractory Multiple Myeloma

    Scientists sought to understand how the programmed death ligand 1 inhibitor durvalumab and the immunomodulatory agent pomalidomide regulated immune cell activation and function in patients with relapsed/refractory multiple myeloma.
    [Scientific Reports]

    Full Article


    Webinar on Modeling arrhythmias using hPSC-derived cardiomyocytes
    REVIEWS

    Immune Cell Compartmentalization for Brain Surveillance and Protection

    The authors describe the immune niches within the brain, the contribution of professional immune cells to brain functions, the bidirectional relationships between the central nervous system and the immune system and the relevance of immune components to brain aging and neurodegenerative diseases.
    [Nature Immunology]

    Abstract

    INDUSTRY AND POLICY NEWS

    US Food and Drug Administration Accepts for Priority Review Bristol Myers Squibb’s Application for Orencia (abatacept) for the Prevention of Acute Graft Versus Host Disease (aGvHD)

    Bristol Myers Squibb announced that the FDA has accepted its supplemental Biologics License Application for Orencia for the prevention of moderate to severe aGvHD in patients six years of age and older receiving unrelated donor hematopoietic stem cell transplantation.
    [Bristol Myers Squibb]

    Press Release

    FEATURED EVENT

    Vitamin D Workshop

    October 13 – 14, 2021
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    JOB OPPORTUNITIES

    Clinical Research Associate – Cancers, Diabetes, Cardiovascular Disease

    National University of Ireland Galway – Galway, Ireland

    Senior Scientist – Immuno-Oncology

    Epitopea – Cambridge, England, United Kingdom

    Staff Researcher – Immune Responses after Heart and Lung Transplantation

    Washington University School of Medicine – St. Louis, Missouri, United States

    Postdoctoral Scholar – Immunology, Cancer Immunotherapy, and Protein Engineering

    University of California Irvine – Irvine, California, United States

    Postdoctoral Associate – CAR T-Cell Studies

    Baylor College of Medicine – Houston, Texas, United States

    > See All Jobs

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