Human Immunology News Volume 9.34 | Aug 31 2021

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    2021-08-31 | HIN 9.34


    Human Immunology News by STEMCELL Technologies
    Vol. 9.34 – 31 August, 2021
    TOP STORY

    T Cell Receptor Recognition of Hybrid Insulin Peptides Bound to HLA-DQ8

    HLA-DQ8-HIP tetramer+ T cells from the peripheral blood of a type I diabetes (T1D) patient were characterized by repeated TRBV5 usage, which matched the TCR bias of CD4+ T cells reactive to the hybrid insulin peptide isolated from the pancreatic islets of a patient with T1D.
    [Nature Communications]

    Full Article

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    Functional Th1-Oriented T Follicular Helper Cells That Infiltrate Human Breast Cancer Promote Effective Adaptive Immunity

    Scientists found that CD4+ Tfh tumor infiltrating lymphocyte (TIL), CD8+ TIL and TIL-B, co-localizing in tertiary lymphoid structures, all expressed the CXCL13 receptor CXCR5.
    [Journal of Clinical Investigation]

    AbstractFull ArticleGraphical Abstract

    CD4+ T Cells in the Lungs of Acute Sarcoidosis Patients Recognize an Aspergillus nidulans Epitope

    The authors screened related Löfgren’s syndrome-specific TCRs for antigen specificity and identified a peptide derived from NAD-dependent histone deacetylase hst4 of Aspergillus nidulans that stimulated the CD4+ T cells in an HLA-DR3–restricted manner.
    [Journal of Experimental Medicine]

    Abstract

    Up-Regulation of C/EBPα Inhibits Suppressive Activity of Myeloid Cells and Potentiates Antitumor Response in Mice and Cancer Patients

    Investigators conducted a Phase I trial in 36 patients with hepatocellular carcinoma who were given therapeutic C/EBPα saRNA (MTL-CEBPA) as either neoadjuvant or adjuvant treatment. MTL-CEBPA treatment in those patients caused a marked decrease in peripheral blood monocytic myeloid-derived suppressor cell numbers.
    [Clinical Cancer Research]

    Abstract

    Targeting the Atf7ip-Setdb1 Complex Augments Antitumor Immunity by Boosting Tumor Immunogenicity

    To identify epigenetic regulators of tumor antigen expression, scientists established a transplantable syngeneic tumor model of immune escape with silenced antigen expression and used this system as a platform for a CRISPR-Cas9 suppressor screen for genes encoding epigenetic modifiers.
    [Cancer Immunology Research]

    Abstract

    Cooperativity Mediated by Rationally Selected Combinations of Human Monoclonal Antibodies Targeting the Henipavirus Receptor Binding Protein

    Researchers isolated a panel of human monoclonal antibodies from the B cells of an individual with prior exposure to equine Hendra virus vaccine, targeting distinct antigenic sites.
    [Cell Reports]

    Full ArticleGraphical Abstract

    High-Grade Serous Ovarian Tumor Cells Modulate NK Cell Function to Create an Immune-Tolerant Microenvironment

    Investigators applied mass cytometry and uncover decidual-like natural killer cell subpopulations in newly diagnosed high-grade serous carcinoma samples that correlated with both tumor and transitioning epithelial-mesenchymal cell abundance.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Secretome Screening Reveals Immunomodulating Functions of IFNα-7, PAP and GDF-7 on Regulatory T-cells

    Scientists reported a phenotypic screening of a human secretome library in human Treg cells utilizing a high throughput flow cytometry technology.
    [Scientific Reports]

    Full Article

    P2Y12 Receptor Blockers Are Anti-inflammatory Drugs Inhibiting Both Circulating Monocytes and Macrophages including THP-1 Cells

    The authors identified potential anti-inflammatory effects of P2Y12 receptor blockers on monocytes and macrophages.
    [Scientific Reports]

    Full Article

    Targeted T Cell Receptor Gene Editing Provides Predictable T Cell Product Function for Immunotherapy

    By studying 51 different T cell receptors (TCRs), researchers showed that conventional genetic engineering by viral transduction led to variable TCR expression and functionality as a result of variable transgene copy numbers and untargeted transgene integration.
    [Cell Reports Medicine]

    Full ArticleGraphical Abstract

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    REVIEWS

    The Promise of the Gut Microbiome as Part of Individualized Treatment Strategies

    The authors discuss six broad disease groups: infectious disease, cancer, metabolic disease, cardiovascular disease, autoimmune or inflammatory disease, and allergic and atopic diseases.
    [Nature Reviews Gastroenterology & Hepatology]

    Abstract

    Exploiting Dynamic Enhancer Landscapes to Decode Macrophage and Microglia Phenotypes in Health and Disease

    Scientists review recent advances that have expanded appreciation of the diversity of macrophage phenotypes in health and disease, emphasizing studies of liver, adipose tissue, and brain macrophages as paradigms for other tissue macrophages and cell types.
    [Molecular Cell]

    Abstract

    INDUSTRY AND POLICY NEWS

    ImmunoBrain Checkpoint Awarded $5 Million US NIA Grant for Phase Ib Alzheimer’s Disease Proof-of-Mechanism Study of Anti-PD-L1 IBC-Ab002

    ImmunoBrain Checkpoint, Inc. announced that the National Institute on Aging (NIA) of the US National Institutes of Health has awarded the company a grant totaling $5 million over three years to support a first-in-human clinical study of IBC-Ab002, for the treatment of Alzheimer’s disease.
    [ImmunoBrain Checkpoint, Inc. (GlobeNewswire, Inc.)]

    Press Release

    FEATURED EVENT

    Immuno UK

    October 13 – 14, 2021
    London, England, United Kingdom

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    JOB OPPORTUNITIES

    Assistant Professor – Immunology, Microbiology of Skin and Vaginal Mucosa

    University of Colorado – Aurora, Colorado, United States

    Faculty Position – Translational Immunology

    University of Miami – Miami, Florida, United States

    Staff Researcher – Immune Responses after Heart and Lung Transplantation

    Washington University School of Medicine – St. Louis, Missouri, United States

    Postdoctoral Fellow – Immune Homeostasis of the Intestinal Tract

    University of North Dakota – Grand Forks, North Dakota, United States

    Senior Scientist – Immuno-Oncology

    Epitopea – Cambridge, England, United Kingdom

    > See All Jobs

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