 | | Vol. 9.35 – 7 September, 2021 |
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| Researchers studied CD8 T cells in patients with human papillomavirus (HPV)-positive head and neck cancer and identified several epitopes derived from HPV E2, E5 and E6 proteins that allowed them to analyze virus-specific CD8 T cells using major histocompatibility complex class I tetramers.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators engineered CAR-T cells to deliver RN7SL1, an endogenous RNA that activates RIG-I/MDA5 signaling. RN7SL1 promoted expansion and effector-memory differentiation of CAR-T cells.
[Cell] |
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| Through multiplexed single-cell mRNA sequencing, the authors identified cKit+CD127hiTCF-1hi early differentiation stages of T-bet+ innate lymphoid cells.
[Nature Immunology] |
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| The authors found that a small number of TCF1+ tumor-specific CD8+ T cells were present in lung tumors throughout their development.
[Science Immunology] |
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| Using multiplex immunofluorescence staining in cohorts of anti-PD-1 and anti-PD-L1-treated lung cancer patients, scientists showed that decreased expression of cancer cell αV was associated with improved immunotherapy-related, progression-free survival.
[Nature Communications] |
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| The average survival time was shorter in patients with JAK/STAT and PHF6 comutation than that in other patients, suggesting a potential role of PHF6 in leukemia progression.
[Leukemia] |
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| Monocytes from stressed mice and humans exhibit a characteristic inflammatory transcriptomic signature and are hyperresponsive upon stimulation with Toll-like receptor ligands.
[Cell Reports] |
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| Investigators found that pharmacologic inhibition of neddylation using a small-molecule inhibitor, MLN4924/Pevonedistat, increased the expression of the natural killer (NK) cell-activating receptor NKG2D ligands MICA and MICB on the plasma membrane of different multiple myeloma cell lines and patient-derived plasma cells, leading to enhanced NK cell degranulation.
[Cell Death & Disease] |
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| Scientists aimed to investigate the role of MAPK signaling in childhood asthma and its environment-mediated protection, including a representative selection of 232 out of 1062 children from two cross-sectional cohorts and one birth cohort study.
[Pediatric Allergy and Immunology] |
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| The authors discuss the role of inflammation in initiating epigenetic alterations in immune cells, cancer-associated fibroblasts, and cancer cells and suggest how and when epigenetic interventions can be combined with immunotherapies to improve therapeutic outcomes.
[Cellular & Molecular Immunology] |
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| Scientists summarize recent findings related to intestinal dendritic cells in steady state and upon inflammation, with a special focus on their functional specializations, highly dependent on their microenvironment.
[Mucosal Immunology] |
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| Two National Institute of Health (NIH) grants totaling over $1.3 million will enable research into antibody-mediated drug delivery technology for the treatment of cancer and autoimmune disorders. L. Nathan Tumeyis the Principal Investigator on both grants — $1.2 million from the National Institute of General Medical Sciences and $150,000 from the National Institute of Allergy and Infectious Diseases.
[Bringhamton University] |
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| Brickell Biotech, Inc. announced it has entered into a definitive agreement with Voronoi, Inc. that grants Brickell exclusive, worldwide rights to research, develop and commercialize novel therapeutics generated from a proprietary DYRK1A inhibitor platform.
[Brickell Biotech, Inc.] |
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| October 14 – 15, 2021
London, England, United Kingdom |
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| | Benaroya Research Institute at Virginia Mason – Seattle, Washington, United States |
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| | University Hospital of Bern – Bern, Switzerland |
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| The University of Tennessee Health Science Center – Memphis, Tennessee, United States |
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| University of Colorado – Aurora, Colorado, United States |
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| | University of Miami – Miami, Florida, United States |
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