Human Immunology News Volume 9.38 | Sep 28 2021

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    2021-09-28 | HIN 9.38


    Human Immunology News by STEMCELL Technologies
    Vol. 9.38 – 28 September, 2021
    TOP STORY

    T Lymphocyte Membrane-Decorated Epigenetic Nanoinducer of Interferons for Cancer Immunotherapy

    Scientists created a T lymphocyte membrane-decorated epigenetic nanoinducer that was engineered with programmed cell death protein 1, which they called OPEN, for the delivery of the IFN inducer ORY-1001.
    [Nature Nanotechnology]

    Abstract

    Which Immune cell Are You?
    PUBLICATIONSRanked by the impact factor of the journal

    Follicular Dendritic Cells Restrict Interleukin-4 Availability in Germinal Centers and Foster Memory B Cell Generation

    Researchers examined the contribution of interleukin (IL)-4 on B cell fate decisions in the germinal center (GC). Single-cell RNA-sequencing identified a subset of light zone GC B cells expressing high IL-4 receptor-a and CD23 and lacking a Myc-associated signature.
    [Immunity]

    AbstractGraphical Abstract

    OCT2 Pre-Positioning Facilitates Cell Fate Transition and Chromatin Architecture Changes in Humoral Immunity

    Mapping chromatin accessibility during the humoral immune response, scientists showed that OCT2 was the dominant transcription factor linked to differential accessibility of germinal center regulatory elements.
    [Nature Immunology]

    Abstract

    Site-Specific PEGylation of Interleukin-2 Enhances Immunosuppression via the Sustained Activation of Regulatory T Cells

    The authors showed that the pharmacokinetics and half-life of IL-2 could be substantially improved by orthogonally conjugating the cytokine to poly(ethylene glycol) (PEG) moieties via a copper-free click reaction through the incorporation of azide-bearing amino acids at defined sites.
    [Nature Biomedical Engineering]

    Full Article

    Deep Learning-Based Prediction of the T Cell Receptor–Antigen Binding Specificity

    Investigators discovered that patients with more clonally expanded T cells that exhibited better affinity against truncal rather than subclonal neoantigens had more favorable prognosis and treatment response to immunotherapy in melanoma and lung cancer.
    [Nature Machine Intelligence]

    Abstract

    9p21 Loss Confers a Cold Tumor Immune Microenvironment and Primary Resistance to Immune Checkpoint Therapy

    Researchers demonstrated that 9p21 loss confers “cold” tumor-immune phenotypes, characterized by reduced abundance of tumor-infiltrating leukocytes, particularly, T/B/NK cells, altered spatial TILs patterns, diminished immune cell trafficking/activation, decreased rate of PD-L1 positivity, along with activation of immunosuppressive signaling.
    [Nature Communications]

    Full Article

    CD8+ T Effector and Immune Checkpoint Signatures Predict Prognosis and Responsiveness to Immunotherapy in Bladder Cancer

    348 pretreated metastatic urothelial cancer samples from the IMvigor210 cohort were used to identify important genes significantly associated with CD8+ T effector and immune checkpoint signatures.
    [Oncogene]

    Abstract

    Characterization of Peri-Implantation Endometrial Treg and Identification of an Altered Phenotype in Recurrent Pregnancy Loss

    Researchers identified an endometrial Treg transcriptomic signature and validated an enhanced regulatory phenotype compared to peripheral blood Treg.
    [Mucosal Immunology]

    Full Article

    TCF4 Enhances Hepatic Metastasis of Colorectal Cancer by Regulating Tumor-Associated Macrophage via CCL2/CCR2 Signaling

    Scientists found tumor-associated macrophage recruitment and M2 polarization were increased in the hepatic metastatic lesion compared with the primary site of human colorectal cancer tissues.
    [Cell Death & Disease]

    Full Article

    Direct Tissue-Sensing Reprograms TLR4+ Tfh-Like Cells Inflammatory Profile in the Joints of Rheumatoid Arthritis Patients

    Investigators identified a TLR4+ follicular helper T cell-like population present in the blood and expanded in synovial fluid.
    [Communications Biology]

    Full Article

    Single-Cell Profiling Defines the Prognostic Benefit of CD39high Tissue Resident Memory CD8+ T Cells in Luminal-Like Breast Cancer

    By using high-dimensional single-cell technologies, scientists identified heterogeneous behavior within the tissue-resident memory CD8+ T cells infiltrating luminal-like tumors.
    [Communications Biology]

    Full Article

    Explore scientific events this October with the Science Events Calendar.
    REVIEWS

    Enhancing Immunotherapy in Cancer by Targeting Emerging Immunomodulatory Pathways

    Scientists discuss the translational potential and clinical development of agents targeting both co-stimulatory and co-inhibitory T cell receptors.
    [Nature Reviews Clinical Oncology]

    Abstract

    Autoimmmune Hepatitis

    The authors offer a comprehensive overview of pathophysiological and clinical aspects of autoimmune hepatitis.
    [Cellular & Molecular Immunology]

    Full Article

    INDUSTRY AND POLICY NEWS

    Esker Therapeutics Announces Management and Research Team Additions to Accelerate Advancement of Precision Immunology Therapies

    Esker Therapeutics, Inc. announced that Martin Babler has joined the company as president, chief executive officer and chairman of the board of directors. Esker will accelerate the development of precision medicine as a standard of care in immunology by focusing on three strategic pillars.
    [Esker Therapeutics, Inc. (BusinessWire, Inc.)]

    Press Release

    Pfizer Starts Study of mRNA-Based Next Generation Flu Vaccine Program

    Pfizer, Inc. announced that the first participants have been dosed in a Phase I clinical trial to evaluate the safety, tolerability, and immunogenicity of a single dose quadrivalent mRNA vaccine against influenza in healthy adults.
    [Pfizer, Inc.]

    Press Release

    FEATURED EVENT

    ISSCR: Stem Cells – From Basic Science to Clinical Translation

    October 27 – 29, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Scientist – Cancer Cell Signaling

    The University of New Mexico – Albuquerque, New Mexico, United State

    Faculty and Leadership Positions – Cancer-Focused Target and Drug Discovery

    The University of New Mexico – Albuquerque, New Mexico, United States

    Postdoctoral Fellow – Molecular and Cellular Oncology

    The University of Texas MD Anderson Cancer Center – Houston, Texas, United States

    PhD Scientists – Tumor Immune Microenvironment

    Moores Cancer Center, UC San Diego – San Diego, California, United States

    Postdoctoral Associate – Mucosal Immunology

    Scripps Research Florida – Jupiter, Florida, United States

    > See All Jobs

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