 | | Vol. 9.40 – 12 October, 2021 |
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| Researchers conducted a Phase I trial in pediatric and young adult patients with relapsed or refractory B cell acute lymphoblastic leukemia to test AUTO3, autologous transduced T cells expressing both anti-CD19 and anti-CD22 chimeric antigen receptors (CARs).
[Nature Medicine] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists showed that eosinophil extracellular traps in bronchoalveolar lavage fluid were associated with the severity of asthma in patients.
[Nature Cell Biology] |
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| The authors analyzed CD127+ innate lymphoid cells (ILCs) and natural killer cells in intestinal lamina propria from healthy donors and Crohn’s disease patients and identified two populations of CD127+CD94+ ILCs, designated population A and B, that could be distinguished on the expression of CD117, CD18 and cytotoxic molecules.
[Nature Communications] |
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| Stereotactic ablative radiotherapy induced anti-tumor immunity in clinical and preclinical studies, but immunological biomarkers were lacking.
[Clinical Cancer Research] |
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| Researchers examined the immune cell profile of eight cell suspension samples of Lymphocyte-rich classic Hodgkin lymphoma (LR-CHL) in comparison to 20 samples of the mixed cellularity and nodular sclerosis subtypes of CHL.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Programmed death ligand 1 (PD-L1) expression in human ovarian cancer cells after PARP inhibitors treatment was examined by western blotting and flow cytometry.
[Journal of Translational Medicine] |
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| Researchers investigated the significance of soluble programmed death-1 ligand (sPD-L1) in cancer patients receiving immune checkpoint inhibitor therapy.
[Scientific Reports] |
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| To explore the relationship between PLCγ2 and TREM2 and the role of PLCγ2 in regulating immune cell function, the authors generated human iPSC- derived macrophages from isogenic lines with homozygous PLCG2 knockout.
[Scientific Reports] |
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| The authors revealed the mechanism of neutrophil extracellular traps generation and their role in trophoblast apoptosis in gestational diabetes mellitus.
[Cellular Signalling] |
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| Expression profile of TLRs in peripheral and tumor-infiltrating CD8+ T cells was investigated. Purified CD8+ T cells were stimulated with Pam3Csk4, an agonist of TLR2, and cytotoxic and co-inhibitory molecules in CD8+ T cells was measured.
[BMC Immunology] |
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| Our understanding of the impact of host-intrinsic factors has evolved substantially over the past decade, with greater insights on these factors and on tumor and immune co-evolution.
[Cell] |
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| T cells located in non-lymphoid tissues have come to prominence in recent years. CD8+ tissue-resident memory cells are important for tissue immune surveillance, provide an important line of defence against invading pathogens and show promise in cancer therapies.
[Mucosal Immunology] |
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| Researchers announced the integration of PrismRA® into its clinical pathway for patients living with rheumatoid arthritis. Scipher Medicine, the manufacturer of PrismRA, is a precision immunology company helping providers determine the most effective therapy for their patients.
[Trellis Rx] |
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| X4 Pharmaceuticals, Inc. announced that it has completed enrollment in the ongoing pivotal Phase II clinical trial of its lead candidate, mavorixafor, in the treatment of patients with genetically confirmed warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome, a primary immunodeficiency caused by gain-of-function mutations in the CXCR4 gene.
[X4 Pharmaceuticals, Inc.] |
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| November 8 – 10, 2021
Virtual |
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| | University of Manitoba – Winnipeg, Manitoba, Canada |
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| | Colorado State University – Fort Collins, Colorado, United States |
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| | City of Hope – Los Angeles, California, United States |
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| | University of Cambridge – Cambridge, England, United Kingdom |
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| | The University of Texas MD Anderson Cancer Center – Houston, Texas, United States |
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