 | | Vol. 9.43 – 2 November, 2021 |
| |
|
|
| Scientists used high-resolution flow- and mass cytometry to examine NK cell repertoires in 64 patients with neutropenia and 27 healthy age- and gender-matched donors.
[Blood] |
|  |
|
|
| PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| Investigators described a novel combined immunodeficiency due to an IKZF3 mutation in a family presenting with T and B cell involvement, Pneumocystis jirovecii pneumonia, and/or chronic lymphocytic leukemia.
[Journal of Experimental Medicine] |
|
|
|
| Scientists described a non-viral lipid nanoparticle-based delivery system that encapsulated small interfering RNAs to gene silence the key intrinsic inhibitory NK cell molecules, SHP-1, Cbl-b, and c-Cbl.
[EMBO Molecular Medicine] |
|
|
|
| Researchers profiled CD4+ regulatory T cells in a small but well-characterized cohort of extreme slow progressors with a median age 43, that was followed up for 18–32 years.
[Diabetologia] |
|
|
|
| Using a single somatic copy number alteration score inclusive of whole-chromosome, chromosome arm, and focal alterations in a pan-cancer analysis of 9,375 samples in The Cancer Genome Atlas database, scientists found an inverse correlation with a cytotoxicity score across disease stages.
[EMBO Reports] |
|
|
|
| The authors found that apoptosis-associated epitopes-specific CD8+ T cells were present in the lymphoid organs of unprimed mice, proliferated under peptide stimulation in vitro, but failed to respond to peptide immunization in vivo, suggesting a physiological control of this response.
[Cell Death & Disease] |
|
|
|
| Scientists examined the prognosis of hepatocellular carcinoma from a genetic level using clinical databases and single-cell data to identify genes with a high prognostic value.
[Journal of Cellular and Molecular Medicine] |
|
|
|
| Investigators reported a role for excessive neutrophil extracellular trap formation induced by uremic serum on endothelial cell injury.
[Scientific Reports] |
|
|
|
| Univariate and least absolute shrinkage and the selection operator Cox regression methods were used to develop a ferroptosis-related signature using a cohort of glioma patients from the Chinese Glioma Genome Atlas, and was validated using an independent cohort of glioma patients from The Cancer Genome Atlas.
[Bioscience Reports] |
|
|
|
| Researchers investigated β2-adrenoceptor-mediated signaling pathways involved in the production of two pro-inflammatory cytokines, interleukin (IL)-6 and IL-8, in 16HBE14o- human bronchial epithelia.
[Lung] |
|
|
|
|
| Restoration of Treg cell fitness and/or expansion of their numbers using low-dose natural IL-2, the main cytokine driving Treg cell survival and function, has demonstrated clinical efficacy in early clinical trials.
[Nature Reviews Rheumatology] |
|
|
|
| New approaches to enhance the utility of immunotherapy are needed. T cell activation and differentiation status are tightly controlled at the transcriptional, epigenetic, and metabolic levels.
[Cancer Immunology Research] |
|
|
|
| Scientists summarize the understanding of the current state in the human CD8+ T cell subset characterization field.
[Cold Spring Harbor Perspectives in Biology] |
|
|
|
|
| Galecto, Inc. announced that it has entered into a clinical trial supply agreement with Roche to explore the combination of GB1211, Galecto’s oral galectin-3 inhibitor, with Roche’s PD-L1 checkpoint inhibitor atezolizumab in Galecto’s planned Phase IIa trial in non-small-cell lung cancer
[Galecto, Inc.] |
|
|
|
| Ikena Oncology, Inc. announced that the FDA has accepted its Investigational New Drug (IND) application to study its TEAD inhibitor candidate, IK-930, for the treatment of cancers harboring genetic mutations in the Hippo signaling pathway.
[Ikena Oncology, Inc.] |
|
|
|
|
| November 15 – 17, 2021
Virtual |
|
|
|
|
|
| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
|
|
|
| | Benaroya Research Institute at Virginia Mason – Seattle, Washington, United States |
|
|
|
| | Calgary, Alberta, Canada – University of Calgary |
|
|
|
|
| | Boston Children’s Hospital – Boston, Massachusetts, United States |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
