 | | | Vol. 9.43 – 9 November, 2021 |
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| Researchers showed that discoidin domain receptor 1 (DDR1), a collagen receptor with tyrosine kinase activity, instigated immune exclusion by promoting collagen fibre alignment.
[Nature] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors identified the metabolite and neurotransmitter GABA as a candidate signaling molecule synthesized and secreted by activated B cells and plasma cells.
[Nature] |
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| Investigators showed that tumor-specific CD8+ tumor-infiltrating lymphocytes accumulated in tumor islets, where they engage antigen and upregulate PD-1, which restrained their functions.
[Cancer Cell] |
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| Researchers systematically applied Mendelian randomization, genetic colocalization, immune-cell-type enrichment, and phenome-wide association methods to investigate the effects of genetically predicted gene expression on ten immune-associated diseases and four cancer outcomes.
[American Journal of Human Genetics] |
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| Scientists describe a unique, sophisticated combinatorial platform for glioblastoma (GMB): a cooperative multifunctional immunotherapy based on genetically engineered human NK cells bearing multiple antitumor functions including local tumor responsiveness that addresses key drivers of GBM resistance to therapy
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Investigators used an in vitro peristaltic pump setup that mimiced pulsatile blood flow to determine if immune cells took up particles under constant fluidic flow.
[Molecular Pharmaceutics] |
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| The authors addressed the issue of endotoxin levels in laboratory grade Cas9 proteins used to measure T cell memory responses.
[Gene Therapy] |
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| Scientists reported a comprehensive pattern of homeodomain only protein (Hopx) expression in multiple types of immune cells under steady state conditions.
[Heliyon] |
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| By screening a collection of small-molecule compounds, investigators found that inhibiting β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) with MK-8931 potently reprogrammed tumor-promoting macrophages into tumor-suppressive macrophages and promotes macrophage phagocytosis of glioma cells.
[Nature Cancer] |
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| The authors summarize current knowledge on the unique contributions of the two hypoxia-inducible factor (HIF)-α isoforms to tumor progression in the context of the complex tumor immune microenvironment, highlighting important considerations for therapy.
[Trends in Cancer] |
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| Different immune cell subsets in perinatal brain injury including their infiltration routes are reviewed and critical aspects such as sex differences and maturational stage are discussed.
[Pediatric Research] |
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| Inspirna, Inc. announced a collaboration with Bristol Myers Squibb on a clinical trial of a combination therapy using RGX-104, the company’s small molecule agonist of the Liver X Receptor/Apolipoprotein E pathway, and Yervoy®, Bristol Myer Squibb’s Cytotoxic T-Lymphocyte Associated protein 4 inhibitor.
[Inspirna, Inc.] |
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| Australian clinical-stage drug development company Noxopharm has announced its DARRT-2 Phase II clinical trial has commenced with patient enrollment in the US.
[Noxopharm] |
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| November 22 – 23, 2021
Ghent, Belgium |
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| | Oregon Health & Science University – Portland, Oregon, United States |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | Benaroya Research Institute at Virginia Mason – Seattle, Washington, United States |
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| | Calgary, Alberta, Canada – University of Calgary |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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