 | | Vol. 9.44 – 16 November, 2021 |
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| Allergen sensitization to five common indoor allergens was assessed in former smokers with COPD. Home settled dust was assessed for presence of corresponding allergens.
[American Journal of Respiratory and Critical Care Medicine] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| A biphasic hyaluronan (HA) enema suspension, naïve-HA system that protected the dysregulated gut epithelium by decreasing the inflammation, permeability, and helping in maintaining the epithelial barrier integrity in the dextran sodium sulfate-induced colitis mice model was reported.
[Advanced Science] |
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| High-throughput RNA-seq was used to identify the differentially expressed circular RNAs upon IL-6 stimulation in intrahepatic cholangiocarcinoma cells.
[Hepatology] |
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| Scientists showed that activation of the WNT/β-catenin signaling pathway contributed to the development of a noninflamed tumor microenvironment in tumors with high tumor mutation burden.
[Science Immunology] |
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| Researchers used single-cell multiomics, transgenic murine models, and functional approaches to define extrathymic Aire-expressing cells at the transcriptional, genomic, and proteomic level.
[Science Immunology] |
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| Using an immune “hot” mouse ovarian cancer model, scientists found that cancer-associated-MSCs drove CD8+ T cell tumor immune exclusion and reduced response to anti–PD-L1 immune checkpoint inhibitor via secretion of numerous chemokines.
[Science Advances] |
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| The authors demonstrated that inhibition of fibroblast growth factor receptor 3 (FGFR3) in FGFR3-activated bladder cancer elevated PD-L1 protein levels by affecting its ubiquitination, thereby inhibiting the anti-tumor activity of CD8+ T cells.
[Cancer Research] |
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| Researchers reported that desmosterol, the most abundant cholesterol biosynthetic intermediate in human coronary artery lesions, played an essential role during atherogenesis, serving as a key molecule integrating cholesterol homeostasis and immune responses in macrophages.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Scientists examined the role of miR-29 in neonatal and adult CD8+ T cells, which expressed different amounts of miR-29 only prior to infection and adopt profoundly different fates after immune challenge.
[Cell Reports] |
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| Human and mouse NK cell populations with high responsiveness had low Src homology 2 domain–containing phosphatase-1 (SHP-1) abundance, and a reduction in SHP-1 abundance in NK cells enhanced their responsiveness.
[Science Signaling] |
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| By combining hematopoietic stem cell (HSC) gene engineering and in vitro differentiation, scientists generated human allogeneic HSC-engineered invariant natural killer T cells at high yield and purity.
[Cell Reports Medicine] |
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| Investigators summarize the roles of the kynurenine pathway and its metabolites in acute kidney injury and chronic kidney disease based on current literature evidence.
[American Journal of Nephrology] |
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| Oncotelic Therapeutics, Inc. provided an update on ongoing OT-101/IL-2 combination trial which successfully completed the safety evaluation of its safety cohort, allowing for further expansion of its clinical program into Phase II clinical trials and higher doses.
[Oncotelic Therapeutics, Inc.] |
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| Shanghai Junshi Biosciences Co., Ltd. and Coherus Biosciences, Inc. announced that the FDA has granted Orphan Drug Designation for toripalimab for the treatment of esophageal cancer.
[Shanghai Junshi Biosciences Co., Ltd. (GlobeNewswire, Inc.)] |
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| December 1 – 10, 2021
Virtual |
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| | AbCellera – Vancouver, British Columbia, Canada |
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| | UC San Diego Health – La Jolla, California, United States |
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| | Oregon Health & Science University – Portland, Oregon, United States |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | Benaroya Research Institute at Virginia Mason – Seattle, Washington, United States |
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