Human Immunology News Volume 9.47 | Nov 30 2021

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    2021-11-30 | HIN 9.46


    Human Immunology News by STEMCELL Technologies
    Vol. 9.46 – 30 November, 2021
    TOP STORY

    Neoantigen-Reactive CD8+ T Cells Affect Clinical Outcome of Adoptive Transfer with Tumor-Infiltrating Lymphocytes in Melanoma

    Using barcoded pMHC multimers, scientists provided a comprehensive mapping of CD8+ T cells recognizing neoepitopes in Tumor-Infiltrating Lymphocyte infusion products and blood samples from 26 metastatic mela-noma patients who received adoptive cell therapy.
    [Journal of Clinical Investigation]

    AbstractFull Article
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    PUBLICATIONSRanked by the impact factor of the journal

    Peanut Oral Immunotherapy Differentially Suppresses Clonally Distinct Subsets of T Helper Cells

    Using single-cell RNA sequencing and paired TCRα/β sequencing, researchers assessed the transcriptomes of CD154+ and CD137+ peanut-reactive T helper cells from 12 peanut-allergic patients longitudinally throughout oral immunotherapy.
    [Journal of Clinical Investigation]

    AbstractFull Article

    Anlotinib Induces a T Cell-Inflamed Tumor Microenvironment by Facilitating Vessel Normalization and Enhances the Efficacy of PD1 Checkpoint Blockade in Neuroblastoma

    Investigators proved that anlotinib facilitates tumor vessel normalization at least partially through CD4+ T cells, reprogramed the immunosuppressive tumor microenvironment (TME) into an immunostimulatory TME, significantly inhibited tumor growth and effectively prevented systemic immunosuppression.
    [Clinical Cancer Research]

    AbstractFull Article

    Single-Cell Landscape of Peripheral Immune Responses to Fatal SFTS

    Researchers showed that the single-cell landscape of peripheral immune responses is reprogrammed in thrombocytopenia syndrome (SFTS) and characterized by monocyte shift to an intermediate type along with complement activation, perturbation of plasmablast composition, and highly exhausted T cells.
    [Cell Reports]

    AbstractFull ArticleGraphical Abstract

    Remote Immune Processes Revealed by Immune-Derived Circulating Cell-Free DNA

    The authors characterized cell free DNA released from specific immune cell types in healthy individuals, cross sectionally and longitudinally.
    [eLife]

    AbstractDownload Full Article

    Sequential Modulation of the Wnt/β-Catenin Signaling Pathway Enhances Tumor-Intrinsic MHC I Expression and Tumor Clearance

    Human tumor samples and in vivo patient-derived xenograft and syngeneic murine models were administered Wnt/β-catenin modulating agents DKN-01 and CGX-1321 individually or in sequence
    [Gynecological Oncology]

    Abstract

    Luxeptinib Disables NLRP3 Inflammasome-Mediated IL-1β Release and Pathways Required for Secretion of Inflammatory Cytokines IL-6 and TNFα

    Luxeptinib inhibited the release of three cytokines from THP-1 monocytes and macrophages at concentrations of 0.1 µM and above.
    [Biochemical Pharmacology]

    AbstractGraphical Abstract

    Correlation of CCL8 Expression with Immune Cell Infiltration of Skin Cutaneous Melanoma: Potential as a Prognostic Indicator and Therapeutic Pathway

    Data from 471 skin cutaneous melanoma patients in the The Cancer Genome Atlas were analyzed using ESTIMATE algorithms to generate an ImmuneScore, StromalScore, and EstimateScore for each patient.
    [Cancer Cell International]

    Full Article

    Dual-Targeting Vaccine of FGL1/CAIX Exhibits Potent Anti-Tumor Activity by Activating Dendritic Cells Mediated Multi-Functional CD8 T Cell Immunity

    A novel DNA vaccine containing dual antigens of fibrinogen-like protein 1 and carbonic anhydrase IX was developed and intramuscularly delivered by PLGA/PEI nanoparticles for renal cancer therapy.
    [Molecular Therapy-Oncolytics]

    AbstractDownload Full ArticleGraphical Abstract

    NR2F2 Controls Malignant Squamous Cell Carcinoma State by Promoting Stemness and Invasion and Repressing Differentiation

    Using transcriptional profiling of cancer stem cells from benign tumors and malignant skin squamous cell carcinoma (SCC), scientists identified the nuclear receptor NR2F2 as uniquely expressed in malignant SCC.
    [Nature Cancer]

    Abstract
    Dr. Jackie Damen discusses why the CFU assay should be a vital part of your cell therapy workflow in this on-demand webinar.
    REVIEWS

    Antimetastatic Defense by CD8+ T Cells

    Research on CD8+ T cell-dependent antitumor immunity has classically focused on its role in the primary tumor.
    [Trends in Cancer]

    Abstract

    Mucosal Tissue Regulatory T Cells Are Integral in Balancing Immunity and Tolerance at Portals of Antigen Entry

    Tregs have been extensively studied in lymphoid tissues, and a growing body of work has characterized phenotypically distinct Tregs localized in various nonlymphoid tissue compartments.
    [Mucosal Immunology]

    Abstract

    Transcriptional Control of Gene Expression and the Heterogeneous Cellular Identity of Erythroblastic Island Macrophages

    The authors suggest novel expression characteristics that will enable a clear enrichment of erythroblastic island subtypes and resolution of island macrophage heterogeneity.
    [Frontiers in Genetics]

    Full Article
    INDUSTRY AND POLICY NEWS

    Bristol Myers Squibb’s Applications for Deucravacitinib for the Treatment of Moderate to Severe Plaque Psoriasis Accepted by US Food and Drug Administration and Validated by European Medicines Agency

    Bristol Myers Squibb announced that the US FDA has accepted the New Drug Application and the European Medicines Agency has validated the Marketing Authorization Application for deucravacitinib for the treatment of adults with moderate to severe plaque psoriasis.
    [Bristol Myers Squibb]

    Press Release

    Longeveron Announces Phase II Clinical Trial in Japan to Test Safety and Efficacy of Lomecel-B on Aging Frailty Patients

    Longeveron, Inc. announced that it has entered into a sponsored clinical research agreement with the National Center for Geriatrics and Gerontology and Juntendo University Hospital in Japan, to explore the safety and efficacy of Lomecel-B in older, frail Japanese subjects.
    [Longeveron, Inc.]

    Press Release
    FEATURED EVENT

    ESMO Immuno-Oncology Congress

    December 8 – 11, 2021
    Geneva, Switzerland

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    JOB OPPORTUNITIES

    Professors – Synthetic Biology in Cancer Immunotherapy

    The University of Chicago – Chicago, Illinois, United States

    PhD Positions – Cell Surface Glycome

    The University of British Columbia – Vancouver, British Columbia, Canada

    Scientific Researcher – Cancer Immunology

    Genentech – San Francisco, California, United States

    Research Scientist – Immunology

    AbCellera – Vancouver, British Columbia, Canada

    Scientist – Immune System-Tumor Interactions

    Oregon Health & Science University – Portland, Oregon, United States

    > See All Jobs

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