 | | Vol. 9.48 – 7 December, 2021 |
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| Scientists assessed the prospective association of 48 immune-mediated diseases with the risk of total and individual cancers and the prospective association of organ-specific immune-mediated diseases with the risk of local and extralocal cancers.
[JAMA Oncology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors undertook molecular and functional studies to interrogate the significance of the myeloid Ikaros–SIRT1 axis in the innate immune activation and to determine whether it served as a homeostatic sentinel in hepatic rejuvenation in mouse and human liver.
[Journal of Hepatology] |
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| Investigators found that monophosphoryl lipid A (MPLA) self-assembled with saponins to form particles physically resembling immune-stimulatory complexes, which they termed saponin/MPLA nanoparticles.
[Science Immunology] |
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| Researchers found that the core microRNA biogenesis and targeting machinery maintained the sensitivity of cancer cells to PD-1-independent T cell-mediated cytotoxicity.
[Nature Communications] |
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| A total of 20 immune cell subtypes were identified among 46,040 cells. The function of immune cells in acute rejection were illustrated simultaneously.
[Basic Research in Cardiology] |
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| Using exome sequencing, RNA-sequencing, and functional immunologic studies, scientists characterized 28 normal karyotype (NK)-AML patients with over 5 year first remissions after chemotherapy and compared them to a well-matched group of 31 NK-AML patients who relapsed within two years.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| The authors probed the heterogeneity present among naive CD4+ T cells before encountering their cognate antigen to ask whether their effector potential was modulated by pre-existing transcriptional and chromatin landscape differences.
[Cell Reports] |
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| Human CD8+ T lymphocytes from multiple sclerosis donors and age/sex-matched healthy controls were isolated to evaluate the functional impact of soluble UL16-binding protein 4 (ULBP4).
[Neurology-Neuroimmunology & Neuroinflammation] |
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| Poliovirus receptor- related immunoglobulin domain-containing (PVRIG) blockade significantly enhanced NK-cell killing of poliovirus receptor-related 2+, poliovirus receptorlo acute myeloid leukemia cell lines, and significantly increased NK-cell activation and degranulation in the context of patient primary AML blasts.
[Haematologica] |
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| Researchers demonstrated that the immune activation score based on dynamic alteration of interleukins in patient plasma as early as two cycles after starting immunotherapy could accurately predict immunotherapy efficacy.
[The Innovation] |
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| Investigators offer a brief review of new insights into human NK cell diversity specifically defined by next generation sequencing and single-cell transcriptomic studies.
[Current Opinion in Immunology] |
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| NK cells have always been thought to be short-lived and with no antigen specificity; however, recent data supports the presence of NK cell memory including in the hapten-specific contact hypersensitivity model and in certain viral infections.
[Stem Cell Research & Therapy] |
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| InteRNA Technologies announced it received Investigational New Drug (IND) clearance from the US FDA for the company’s Phase I clinical trial evaluating lead miRNA candidate, INT-1B3, in patients with advanced solid tumors.
[InteRNA Technologies] |
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| PDS Biotechnology Corporation announced the reopening of recruitment in the National Cancer Institute-led Phase II clinical trial evaluating PDS0101 in combination with two investigational immune-modulating agents in advanced HPV cancers.
[PDS Biotechnology Corporation] |
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| January 16 – 20, 2022
Banff, Alberta, Canada |
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| | Allen Institute – Seattle, Washington, United States |
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| | King’s College London – London, England, United Kingdom |
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| | The University of Chicago – Chicago, Illinois, United States |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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| | Genentech – San Francisco, California, United States |
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