Human Immunology News Volume 9.49 | Dec 14 2021

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    2021-12-14 | HIN 9.49


    Human Immunology News by STEMCELL Technologies
    Vol. 9.49 – 14 December, 2021
    TOP STORY

    Interleukin-10 Receptor Signaling Promotes the Maintenance of a PD-1int TCF-1+ CD8+ T Cell Population That Sustains Anti-Tumor Immunity

    Inhibition of IL-10R signaling altered chromatin accessibility and disrupted cooperativity between the transcription factors NFAT and AP-1, promoting a distinct NFAT-associated program.
    [Immunity]

    AbstractGraphical Abstract
    Stay current with COVID-19 research. Read Immunology of Infectious Disease News now.
    PUBLICATIONSRanked by the impact factor of the journal

    Novel Low-Avidity Glypican-3 Specific CARTs Resist Exhaustion and Mediate Durable Antitumor Effects against Hepatocellular Carcinoma

    Investigators developed low-affinity monoclonal antibodies and low-avidity Chimeric antigen receptor engineered T cells (CARTs) for hepatoceullar carcinoma and to test the hypothesis that low-avidity CARTs could resist exhaustion and maintain functions in solid tumors, generating durable antitumor effects.
    [Hepatology]

    Abstract

    Effective CD4 T Cell Priming Requires Repertoire Scanning by CD301b+ Migratory cDC2 Cells upon Lymph Node Entry

    Researchers showed that recently homed naïve polyclonal CD4 T cells were temporarily retained before leaving the lymph node.
    [Science Immunology]

    Abstract

    Depletion of Central Memory CD8+ T Cells Might Impede the Antitumor Therapeutic Effect of Mogamulizumab

    The authors showed that despite a significant reduction in peripheral effector Treg cells, clinical responses are minimal in a cohort of patients with advanced CCR4-negative solid cancer in a Phase Ib study.
    [Nature Communications]

    Full Article

    Glutathione Synthesis Primes Monocytes Metabolic and Epigenetic Pathway for β-Glucan-Trained Immunity

    Researchers reported that β-glucan-trained macrophages from mice harboring a myeloid-specific deletion of the catalytic subunit of glutamate-cysteine ligase showed impaired glutathione synthesis and decreased proinflammatory cytokine production in response to lipopolysaccharide challenge.
    [Redox Biology]

    Full ArticleGraphical Abstract

    SOX10 Requirement for Melanoma Tumor Growth Is Due, in Part, to Immune-Mediated Effects

    The authors investigated immune-related targets of SOX10 and observed positive regulation of herpesvirus entry mediator and carcinoembryonic-antigen cell-adhesion molecule 1.
    [Cell Reports]

    Abstract

    Bruton’s Tyrosine Kinase (BTK) Regulates Myeloid Cell Recruitment during Acute Inflammation

    Investigators explored the role of BTK on the migration of myeloid cells; in vitro using chemotaxis assays and in vivo using zymosan induced peritonitis as model systems.
    [British Journal of Pharmacology]

    Abstract

    Peripheral Immunophenotyping of AITD Subjects Reveals Alterations in Immune Cells in Pediatric vs Adult-Onset AITD

    Researchers performed phenotypic and functional characterization of peripheral blood immune cells from pediatric and adult-onset autoimmune thyroid disease (AITD) patients and age-matched controls using mass cytometry.
    [iScience]

    AbstractFull Article

    Impact of Hydroxyurea on Lymphocyte Subsets in Children with Sickle Cell Anemia

    Scientists evaluated the effect of hydroxyurea on immune profiles through a controlled prospective cohort study conducted in 30 children with sickle cell anemia and 30 healthy age-matched controls.

    Abstract

    Learn about immunological considerations for hPSC banking by watching Dr. David Turner's webinar from the Nature Research Round Table on hPSC Quality
    REVIEWS

    Immune Cells in Cardiac Homeostasis and Disease: Emerging Insights from Novel Technologies

    The authors summarize novel findings on immune cell heterogeneity and functions in cardiac disease with a focus on myocardial infarction as a prototypic example.
    [European Heart Journal]

    Abstract
    Graphical
    Abstract

    T Cell Receptor (TCR) Signaling in Health and Disease

    Investigators provide a comprehensive snapshot of the various molecules involved in regulating T cell receptor signaling, covering both enzymes and adaptors, and discuss their role in human disease.
    [Signal Transduction and Targeted Therapy]

    Abstract
    INDUSTRY AND POLICY NEWS

    HiberCell to Collaborate with Merck on Phase II Clinical Trial of Odetiglucan in Combination with KEYTRUDA® (Pembrolizumab) in Patients with Metastatic Breast Cancer

    HiberCell announced a clinical trial collaboration with Merck. This metastatic breast cancer clinical trial evaluates KEYTRUDA®, Merck’s anti-PD-1 therapy, in combination with HiberCell’s odetiglucan, a Dectin-1, pattern recognition receptor agonist.
    [HiberCell, Inc.]

    Press Release

    Nanjing Leads Biolabs and BeiGene Announce Worldwide License and Collaboration Agreement for LBL-007 Anti-LAG-3 Antibody; BeiGene Granted Exclusive Commercialization Rights Outside of China

    BeiGene announced entry into a license and collaboration agreement granting BeiGene worldwide research, development and manufacturing rights and exclusive commercialization rights outside of China to LBL-007, a novel investigational antibody targeting the LAG-3 pathway.
    [BeiGene LTD]

    Press Release
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    JOB OPPORTUNITIES

    Postdoctoral Researcher – CAR T Cells Engineered to Treat Multiple Myeloma

    Memorial Sloan Kettering – New York City, New York, United States

    Scientist – Single Cell Technologies

    Allen Institute – Seattle, Washington, United States

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    King’s College London – London, England, United Kingdom

    Professors – Synthetic Biology in Cancer Immunotherapy

    The University of Chicago – Chicago, Illinois, United States

    PhD Positions – Cell Surface Glycome

    The University of British Columbia – Vancouver, British Columbia, Canada

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