 | | Vol. 14.11 – 25 March, 2022 |
| |
|
|
| The authors presented a microbial-based immunotherapeutic treatment for selective delivery of an immunogenic tetanus toxoid protein into pancreatic ductal adenocarcinom tumor cells by attenuated Listeria monocytogenes.
[Science Translational Medicine] |
|
 |
|
|
| PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| Researchers developed a localized drug delivery system with a step-by-step cell internalization ability based on a hierarchical-structured fiber device.
[ACS Nano] |
|
|
|
| Using a mouse model of chronic allergen exposure followed by an allergen-free rest period, scientists characterized a subpopulation of CD4+ T cells that secreted IL-9 as an obligate effector cytokine.
[Science Immunology] |
|
|
|
| By investigating the resistance mechanisms, the authors found that MCL1 and JUNB modulated the mitochondrial apoptosis pathway. JUNB encoded a transcription factor that downregulates FasL and TRAIL receptors, upregulated the MCL1 relative BCL2A1, and activated the NF-κB pathway.
[Nature Communications] |
|
|
|
| Investigators showed that human PD-1 (T cell immunoglobulin mucin domain-containing protein 3)+Tim-3+ CD8+ tumor-infiltrating lymphocytes upregulated phosphatidylserine, a receptor for Tim-3, and acquire cell surface myeloid markers from antigen presenting cells through transfer of membrane fragments called trogocytosis.
[Journal of Clinical Investigation] |
|
|
|
| Researchers studied a previously uncharacterized nuclear protein, Atossa, which supported macrophage invasion into the germband of Drosophila by controlling cellular metabolism.
[EMBO Journal] |
|
|
|
| The authors identified the importance of the hypoxia-inducible lipid droplet–associated protein and the intracellular adipose triglyceride lipase in the regulation of lipid accumulation and breakdown in inflammatory macrophages.
[Proceedings of the National Academy of Sciences of the United States of America] |
|
|
|
| Using an aggressive melanoma tumor model, scientists targeted P-selectin glycoprotein ligand-1 (PSGL-1) in tumor-bearing mice and found increased effector CD4+ and CD8+ T cell responses and decreased regulatory T cells in tumors.
[Cancer Immunology Research] |
|
|
|
| Investigators reported that serine 182 phosphorylation was a major post-translational modification was not involved in thymic T cell development and effector T cell differentiation.
[Cell Reports] |
|  |
|
|
|
| Current evidence points towards infiltrating monocytes as also playing a role in neuron death. Further characterization of the successive molecular changes in both the resident and peripheral immune cells invading the Parkinson’s disease brain will provide targets for disease modification.
[Neurobiology of Disease] |
|
|
|
| The authors summarize the advances in our understanding of the ability of different types of toll-like receptors and their downstream signaling pathways to activate anti-tumor immunity in T cells.
[International Immunology] |
|
|
|
|
| Morphic Therapeutic announced the initiation of MORF-057-201, the EMERALD-1 study, a Phase IIa trial of MORF-057 in patients with moderate to severe ulcerative colitis.
[Morphic Therapeutic] |
|
|
|
|
| April 20 – 22, 2022
Lisbon, Portugal |
|
|
|
|
|
| | Princeton University – Princeton, New Jersey, United States |
|
|
|
| | Wellcome Sanger Institute – Cambridge, England, United Kingdom |
|
|
|
| | Princess Margaret Cancer Center – Toronto, Ontario, Canada |
|
|
|
| NIH National Institute on Aging – Baltimore, Maryland, United States |
|
|
|
| | McGill University – Montreal, Quebec, Canada |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
